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Org Biomol Chem
; 22(25): 5087-5092, 2024 06 26.
Article
in English
| MEDLINE
| ID: mdl-38835316
ABSTRACT
We have devised a supported-amine-catalyzed efficient synthesis of spiro-thiazolone-tetrahydrothiophenes via a sulfa-Michael/aldol cascade approach. The catalyst demonstrated sustained efficacy over 21 cycles. These derivatives were found to exhibit excellent binding abilities with purified human serum albumin as indicated by both in silico and in vitro-based experiments.