ABSTRACT
Muscle overactivity (spasticity, dystonia or spasm) seen in certain neuromuscular disorders has been effectively treated with intramuscular injection of botulinum neurotoxins (BTXs). Since they act in the nerve terminals, toxins must be transported to the neuromuscular junctions which are generally clustered in one or more restricted areas (innervations zone(s) (IZs)) in a skeletal muscle. Likewise, IZ targeted BTX injections using guidance is highly recommended to achieve an optimal therapeutic goal with lower doses and fewer side effects. Hence, detection of the injection sites should be based on the knowledge about the localization of the IZs and also the transport mechanism of BTX in skeletal muscle is crucial for intramuscolar application of BTX. In this paper, IZ(s) of the skeletal muscles, distribution of BTX, proper sites and guidance for the injections are discussed taking into account the muscle structure and architecture.
Subject(s)
Botulinum Toxins/administration & dosage , Muscle, Skeletal/innervation , Neuromuscular Agents/administration & dosage , Neuromuscular Diseases/drug therapy , Humans , Injections, IntramuscularABSTRACT
The pertinent literature lacks overt technical data for optimal upper limb muscle botulinum toxin injections using ultrasound (US) imaging. Therefore, this guide is prepared for the commonly injected muscles of the upper limb and the shoulder girdle mainly in spasticity. It includes clinical information, anatomical description and explanation regarding the US imaging of several muscles. The figures have been organized to orient the readers on the innervation, injection sites, probe positioning and the US images simultaneously.
Subject(s)
Botulinum Toxins, Type A/therapeutic use , Spasm/diagnostic imaging , Spasm/drug therapy , Ultrasonography, Doppler/methods , Upper Extremity/physiopathology , Female , Humans , Injections, Intralesional , Injections, Intramuscular , Male , Muscle Spasticity/diagnostic imaging , Muscle Spasticity/drug therapy , Prognosis , Treatment OutcomeABSTRACT
The pertinent literature lacks overt technical data for optimal lower limb muscle botulinum toxin injections using ultrasound (US) imaging. Therefore, this guide is prepared for the commonly injected muscles of the lower limb and the pelvic girdle mainly in spasticity. It includes clinical information, anatomical description and explanation regarding the US imaging of several muscles. The figures have been organized to orient the readers on the innervation zones, injection sites, probe positionings and the US images simultaneously.
Subject(s)
Botulinum Toxins, Type A/therapeutic use , Spasm/diagnostic imaging , Spasm/drug therapy , Ultrasonography, Doppler/methods , Female , Humans , Injections, Intralesional , Injections, Intramuscular , Lower Extremity/physiopathology , Male , Muscle Spasticity/diagnostic imaging , Muscle Spasticity/drug therapy , Prognosis , Treatment OutcomeABSTRACT
The Stroke and Aphasia Quality Of Life Scale (SAQOL-39) is a widely used instrument in assessing the quality of life in aphasic patients. Our purpose was to translate the SAQOL-39 into the Turkish language (SAQOL-39/TR) and assess its reliability and validity in patients who had aphasia. SAQOL-39/TR was obtained using the 'translation-backward translation' method and administered to 40 patients with aphasia. The reliability studies were performed by means of internal consistency and test-retest reliability. The validation studies were carried out by means of construct validity using within-scale analyses and analyses against the external criteria. Correlation analysis was performed between scales and the Ege Aphasia Test, the Barthel index, the 12-item General Health Questionnaire and the Brunnstrom recovery stages (BRS) of the arm, hand, and lower extremity. In the results, the scores of the SAQOL-39 were not different between groups. Cronbach's α variables were good for all domains (0.80, 0.88, 0.89, 0.82, and 0.83). Test-retest reliability was also high (0.96, 0.97, 0.91, 0.70, and 0.96). There were significant correlations with coefficients ranging from 0.36 to 0.60 among the domains of scale and other measures. Moderate-high correlations were also seen with BRS-arm, BRS-hand, and BRS-lower extremity (r, 0.27-0.58). It was found that all domains were highly related with all domains of Ege aphasia test, except praxia (P<0.001). This study showed that the SAQOL-39/TR has acceptable validity and reliability in assessing the quality of life. However, similar results of the scale in patients with dysarthria suggest that the SAQOL-39 may not be specific to only aphasic patients.
Subject(s)
Aphasia/psychology , Cross-Cultural Comparison , Psychometrics/statistics & numerical data , Quality of Life/psychology , Stroke/psychology , Surveys and Questionnaires , Adult , Aged , Disability Evaluation , Female , Humans , Male , Middle Aged , Reproducibility of Results , Statistics as Topic , Translations , TurkeyABSTRACT
Cold application is a simple and inexpensive therapy which has been accepted for decades as an effective nonpharmacologic intervention for pain management. It increases the pain threshold, decreases the inflammatory reaction and spasm. Cold is commonly used in the treatment of acute soft tissue injuries and has been shown to reduce pain effectively in the post-operative period after orthopedic surgery procedures. However, the evidence base to support the common practice of superficial cold is limited and there is a need for future higher-quality randomised controlled trials. The purpose of this review is to explore the literature regarding the physiologic effects of cold, the effectiveness of cold, different modalities used for cold application, and the potential complications associated with the use of cold application.
