ABSTRACT
The incidence of vitamin K deficiency in infancy has decreased markedly, due to prophylactic administration of vitamin K during the neonatal period. However, vitamin K deficiency bleeding may occur during or after the neonatal period despite prophylactic administration in Japan. Two cases are reported of intracranial hemorrhage associated with coagulopathy in full-term infants who had received prophylactic administration of vitamin K. More reliable methods for prophylactic administration should be established.
Subject(s)
Cerebral Hemorrhage/drug therapy , Cerebral Hemorrhage/prevention & control , Vitamin K Deficiency Bleeding/drug therapy , Vitamin K Deficiency Bleeding/prevention & control , Vitamin K/pharmacology , Blood Coagulation Disorders/drug therapy , Blood Coagulation Disorders/etiology , Blood Coagulation Disorders/prevention & control , Cerebral Hemorrhage/etiology , Humans , Infant , Infant, Newborn , Male , Treatment Failure , Vitamin K/physiology , Vitamin K/therapeutic use , Vitamin K Deficiency Bleeding/physiopathologyABSTRACT
We present an extremely rare case of an orbital melanocytoma that occurred in a 51-year-old man. The patient suffered from diplopia and mild exophthalmos of the right eye for 2 months. Brain magnetic resonance imaging showed a well-demarcated round mass 3.5 cm in diameter in the right orbit. We performed total resection of this tumor. Histological findings revealed a proliferation of large polygonal cells with fine pigment granules in the cytoplasm and prominent nucleoli. Although these tumor cells revealed immunohistochemical reactivity in HMB-1, there was no S-100 or Melan A antibody reactivity. Also, there were no malignant findings of nuclear polymorphism, mitoses, or necrosis. The brown pigments were confirmed to be melanin by bleaching and the Fontana-Masson silver stain method. The MIB-1 labeling index was less than 1%. This tumor also consisted of 50% melanophages, which revealed immunohistochemical reactivity in CD68, CD163, and in (1-AT antibodies. These histological findings led us to diagnose an orbital melanocytoma with partial tumor regression.
Subject(s)
Nevus/pathology , Orbital Neoplasms/pathology , Blood Vessels/pathology , Cell Nucleolus/pathology , Coloring Agents , Cytoplasm/pathology , Humans , Immunohistochemistry , Magnetic Resonance Imaging , Male , Melanins/metabolism , Melanosomes/pathology , Middle Aged , Neurosurgical Procedures , Nevus/surgery , Orbital Neoplasms/surgery , Silver Staining , Tissue FixationABSTRACT
The authors report a rare case of a patient with a left-sided T-5 radiculomedullary artery pseudoaneurysm who presented with spinal subarachnoid hemorrhage (SAH). The patient, a 71-year-old woman, was hospitalized for progressive paraplegia and sensory loss with bladder and rectal dysfunction. Computerized tomography scanning revealed an SAH at the posterior fossa. Spinal T2-weighted magnetic resonance imaging demonstrated SAH and an inhomogeneous and slightly low signal intensity mass at T4-5. Spinal angiography revealed a tiny masslike staining without arteriovenous shunting. The resected specimen, which caused the spinal SAH, was diagnosed as a pseudoaneurysm based on operative and pathological findings.
