Immediate radical fang mark ablation may allow treatment of japanese viper bite without antivenom

Administration of antivenom is currently the standard treatment for snake envenomation. However, it can sometimes cause anaphylactic reactions including urticaria, bronchospasm and hypotension. Furthermore, it may also provoke life-threatening complications, even though the mortality rate is less than 1 percent. In this study, we present a new treatment - immediate radical fang mark ablation - that was successfully performed on five victims of Japanese viper bites without antivenom use. In these five victims of venomous snakebites, surgical debridement was immediately performed. Two patients received a free-skin graft to resurface their wounds while three of them healed conservatively (i.e. by ointment treatment without surgery). After treatment, all patients could return to work. Immediate radical ablation is a recommended procedure that can reduce the amount of venom in tissues, which consequently decreases inflammatory reactions and reduces the necessity for antivenom.(AU)

[Treatment of liver metastatic ovarian cancer with sequential administration of OK-432 and etoposide].

OK-432 and etoposide were administered intravenously to a patient with liver metastasis of ovarian cancer. OK-432 induced IFN-gamma and TNF. SuPS and PPD skin reaction became positive after the therapy. The size of metastatic lesions was reduced significantly (partial response). It is suggested that the combination therapy of OK-432 and etoposide may be effective to the liver metastasis of ovarian cancer.

A study on follicle stimulation and ovulation induction in polycystic ovary syndrome (PCOS).

The present study was undertaken to verify the efficacy of preparations for inducing follicular maturation and ovulation in patients with polycystic ovary syndrome (PCOS). Successful induction of ovulation in patients with PCOS was observed in treatment cycles with daily injections or pulsatile subcutaneous administration of human menopausal gonadotropin (hMG), the combination of clomiphene citrate and bromocriptine, or the combination of clomiphene citrate and hMG. The incidence of ovarian hyperstimulation syndrome varied with the different clinical conditions in which ovulation was induced, the types of preparations administered, and the doses and schedules administered.

[Effect of vaginal antibiotics suppository on retroperitoneal-space infection after hysterectomy and lymphadenectomy for uterine cancer].

Effects of vaginal antibiotics suppository on the retroperitoneal-space infection were studied in 42 patients who had hysterectomy and lymphadenectomy with diagnosis of uterine cancer stage I or II. All patients received intravenous administration of 1 g LMOX (3 times/day) for 7 days after operation. One group of patients (21 cases) received 0.5 g of ABPC vaginal suppository (twice/day) for 10 days immediately after operation. Another group of 21 patients did not received vaginal suppository. The LMOX concentrations in the exudate decreased rapidly from the 3rd day to the 7th day. The frequencies of bacterial appearance in the retroperitoneal-space in the vaginal suppository group were 33% on 5th day, 33% on 7th day and 20% on 9th day, while those in the control group were 100%, 100% and 76%, respectively. It was concluded that the administration of vaginal antibiotics suppository was easy to handle and effective for preventing the retroperitoneal-space infection after hysterectomy and lymphadenectomy.

[Clinical study of intraperitoneal chemotherapeutic perfusion (IPCP) of mitomycin C (MMC) and intraperitoneal administration of cisplatin].

IPCP was performed in an attempt to control ascites production by malignant tumors, and its inhibitory effect on ascites production was studied. The subjects were 24 patients who underwent surgery at this department between April 1981 and April 1986, consisting of 19 cases of ovarian cancer, 3 cases of cancer of the uterine body, 1 case of retroperitoneal tumor, and 1 case of metastatic ovarian cancer. As the treatment at the time of laparotomy, 30 mg of MMC was dissolved in 300 ml of normal saline and intraperitoneally administered. After holding for 30 minutes, it was discharged by cleaning out the abdominal cavity with 3,000 ml of normal saline. Immediately before closure of the wound, (A): MMC 10 mg, OK-432 100 KE, neocarzinostatin 4,000 units, or (B): (A) + cisplatin 100mg, was intraperitoneally injected, and the wound was closed without washing out this anticancer cocktail after drainage of the abdominal cavity and abdominal wall. Among the present 24 cases, (A) was applied in 17 cases, and (B) in 7 cases. The inhibitory effect on ascites production was 87.5% or 21/24 cases, specifically 88.2% (15/17) in the (A) group and 85.7% (6/7) in the (B) group. There were no particular side effects.

[A study on alkaline phosphatase in cervical mucus using disc electrophoresis].

A simple filter-disc-absorption technique for sampling human cervical mucus had been developed by colleagues of author. Using this technique, electrophoretic patterns of proteins and phosphorylase in cervical mucus had been reported. In this presentation, I report isoenzyme patterns of alkaline phosphatase (ALP) in the cervical mucus of normal pregnant women and patients with various gynecological diseases using this developed technique. Electrophoresis was carried out with 11.25% polyacrylamide separating gel. The separating gel was prepared using the stacking buffer system at pH 6.7. By this system, the stacking effect was maintained in the gel and the molecular sieve effect was sharpened. ALP activity was demonstrated using 5-bromo-3-indolyl phosphate as the substrate. Placental ALP was identified by its electrophoretic mobility and thermostability. Placental ALP was demonstrated in cervical mucus from 85 pregnant women as early as 6 weeks' gestation. In sera, however, the enzyme activity was demonstrated after 21 weeks' gestation. In cervical mucus and sera of non-pregnant women, and of patients with myoma of the uterus, ovarian tumor and cervical cancer, placental ALP was not demonstrated.