Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Chem Biodivers ; 19(4): e202100970, 2022 Apr.
Article in English | MEDLINE | ID: mdl-35262999

ABSTRACT

The series of novel taurine-derived diarylmethanes and dibenzoxanthenes was synthesized starting from simple commercially available precursors via modular three-stage approach. All the newly synthesized compounds were screened for in vitro antibacterial and antifungal activity, as well as cytotoxicity towards normal and cancer cell lines. Some of the synthesized compounds exhibited 2-4-fold higher activity against S. aureus, E. faecalis and B. cereus compared with Chloramphenicol. In contrast to Chloramphenicol, the tested compounds also showed bactericidal, rather than bacteriostatic effect, which makes them promising candidates for further studies.


Subject(s)
Anti-Infective Agents , Antineoplastic Agents , Anti-Bacterial Agents/pharmacology , Anti-Infective Agents/pharmacology , Antifungal Agents/pharmacology , Antineoplastic Agents/pharmacology , Chloramphenicol , Microbial Sensitivity Tests , Molecular Structure , Staphylococcus aureus , Structure-Activity Relationship , Taurine , Xanthenes
SELECTION OF CITATIONS
SEARCH DETAIL
...