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Immunotropic Properties of an Experimental Synthetic Selenium-Organic Compound.

Yur'eva, O V; Dubrovina, V I; Potapov, V A; Musalov, M V; Starovoitova, T P; Ivanova, T A; Shkaruba, T T; Yakimov, V A; Balakhonov, S V.

Bull Exp Biol Med ; 169(1): 40-42, 2020 May.

Article in English | MEDLINE | ID: mdl-32488779

ABSTRACT

We studied immunotropic properties of synthetic selenium-organic preparation 2,6-dipyridinium-9-selenabicyclo[3.3.1]nonyl dibromide (974zh). The experimental preparation reduced the cAMP/cGMP ratio, which indicated an increase in proliferative activity of cells of immunocompetent organs (thymus and spleen) in experimental animals. It was shown that 974zh intensified the immune response to Yersinia pestis EV thereby increasing the resistance to the plague agent.

Subject(s)

Immunity, Innate/drug effects , Selenium Compounds/pharmacology , Adjuvants, Immunologic/chemistry , Adjuvants, Immunologic/pharmacology , Adjuvants, Immunologic/therapeutic use , Animals , Combined Modality Therapy , Cyclic AMP/metabolism , Cyclic GMP/metabolism , Female , Male , Mice , Organic Chemicals/chemistry , Organic Chemicals/pharmacology , Organic Chemicals/therapeutic use , Plague/drug therapy , Plague/immunology , Plague/prevention & control , Plague Vaccine/administration & dosage , Selenium/chemistry , Selenium/pharmacology , Selenium/therapeutic use , Selenium Compounds/chemistry , Selenium Compounds/therapeutic use , Spleen/drug effects , Spleen/immunology , Spleen/metabolism , Thymus Gland/drug effects , Thymus Gland/immunology , Thymus Gland/metabolism , Vaccine Potency , Virulence/drug effects , Yersinia pestis/drug effects , Yersinia pestis/immunology , Yersinia pestis/pathogenicity

ABSTRACT

Subject(s)

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