EVALUATION OF THE USE OF OZONE THERAPY IN TREATMENT OF INFLAMMATORY PROCESSES IN DIABETES MELLITUS IN AN EXPERIMENT.

Studying the effect of ozone therapy on the course of pyoinflammatory processes with diabetes mellitus in the experiment, conducted on 30 white 24-30 month rats, weight 300-450 gr with purulent-inflammatory processes, it was found out that diabetes, which was simulated by subcutaneous injection of alloxan, causes mosaic disturbances of hemostasis system in the presence of pyoinflammatory processes. Complicated changes in blood condition were also detected against the background of diabetes mellitus: chronometric hypocoagulation on the intrinsic pathway of blood coagulation in association with chronometric hypercoagulation by the external thrombinogenesis mechanism and fibrinogenesis depression against the background of hypofibrinogenaemia. Thus, the use of ozone therapy in the presence of soft tissues abscesses in old rats with diabetes does not demonstrate significant protective properties with reduced azoalbumin lysis, total non-enzymatic fibrinolytic activity and proteinase activity by Kunitz in blood plasma. Such changes in old rats can be considered as an exacerbation of purulent inflammation, increase in toxicity, reduced protective properties, increase in manifestations of hypercoagulation against the background of chronic course of diabetes, caused by age-related changes.

[Clinical use of a new method of inguinal hernia repair].

Surgery is the only treatment for inguinal hernias. The use of allografts has reduced the number recurrences of hernias to 3-14%. However, in any form of alloplasty around implantat develops tissue reaction that causes a number of specific complications. At present, researchers found that in 45-59% of cases of inguinal allogernioplasty leads to a significant disruption of spermatogenic and hormonal functions of the testicle. On the basis of the Surgical Department № 1 (Chernivtsi Emergency Hospital) 61 patients (main group) underwent surgery according to the proposed method (patent of Ukraine for useful model № 81728). The control group included 63 male patients from 19 to 61 years old who underwent inguinal hernia repair by I.L. Lichtenstein. Postoperative recovery periods examined basal activity and disability, pain intensity, the presence of specific complications, length of postoperative hospital stay days, recurrences of hernias. In order to assess reproductive disorders studied the state of blood circulation to the testicular arteries, testicular volume and the level of sex hormones. The prevention of polymeric implant to contact with the components of the spermatic cord reduces the inflammatory response to the structure of the inguinal canal, and the reproductive organs, which leads to a reduction of pain. Also accelerated social and labor rehabilitation of patients, blood circulation is preserved in the testicle and male hormones in the postoperative period. The proposed method prevents the development of recurrences of hernias through the elimination of the deep inguinal ring as one of the weaknesses of the anterior abdominal wall.