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1.
J Hand Surg Am ; 43(5): 417-424, 2018 05.
Article in English | MEDLINE | ID: mdl-29395588

ABSTRACT

PURPOSE: Brachial plexus birth injuries with multiple nerve root avulsions present a particularly difficult reconstructive challenge because of the limited availability of donor nerves. The contralateral C7 has been described for brachial plexus reconstruction in adults but has not been well-studied in the pediatric population. We present our technique and results for retropharyngeal contralateral C7 nerve transfer to the lower trunk for brachial plexus birth injury. METHODS: We performed a retrospective review. Any child aged less than 2 years was included. Charts were analyzed for patient demographic data, operative variables, functional outcomes, complications, and length of follow-up. RESULTS: We had a total of 5 patients. Average nerve graft length was 3 cm. All patients had return of hand sensation to the ulnar nerve distribution as evidenced by a pinch test, unprompted use of the recipient limb without mirror movement, and an Active Movement Scale (AMS) of at least 2/7 for finger and thumb flexion; one patient had an AMS of 7/7 for finger and thumb flexion. Only one patient had return of ulnar intrinsic hand function with an AMS of 3/7. Two patients had temporary triceps weakness in the donor limb and one had clinically insignificant temporary phrenic nerve paresis. No complications were related to the retropharyngeal nerve dissection in any patient. Average follow-up was 3.3 years. CONCLUSIONS: The retropharyngeal contralateral C7 nerve transfer is a safe way to supply extra axons to the severely injured arm in brachial plexus birth injuries with no permanent donor limb deficits. Early functional recovery in these patients, with regard to hand function and sensation, is promising. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic V.


Subject(s)
Brachial Plexus Neuropathies/surgery , Brachial Plexus/surgery , Nerve Transfer/methods , Birth Injuries/complications , Birth Injuries/surgery , Brachial Plexus/injuries , Brachial Plexus Neuropathies/etiology , Female , Follow-Up Studies , Humans , Infant , Male , Recovery of Function , Retrospective Studies , Ulnar Nerve/surgery
2.
J Burn Care Res ; 38(2): 61-70, 2017.
Article in English | MEDLINE | ID: mdl-27404165

ABSTRACT

Stable closure of full-thickness burn wounds remains a limitation to recovery from burns of greater than 50% of the total body surface area (TBSA). Hypothetically, engineered skin substitutes (ESS) consisting of autologous keratinocytes and fibroblasts attached to collagen-based scaffolds may reduce requirements for donor skin, and decrease mortality. ESS were prepared from split-thickness skin biopsies collected after enrollment of 16 pediatric burn patients into an approved study protocol. ESS and split-thickness autograft (AG) were applied to 15 subjects with full-thickness burns involving a mean of 76.9% TBSA. Data consisted of photographs, tracings of donor skin and healed wounds, comparison of mortality with the National Burn Repository, correlation of TBSA closed wounds with TBSA full-thickness burn, frequencies of regrafting, and immunoreactivity to the biopolymer scaffold. One subject expired before ESS application, and 15 subjects received 2056 ESS grafts. The ratio of closed wound to donor areas was 108.7 ± 9.7 for ESS compared with a maximum of 4.0 ± 0.0 for AG. Mortality for enrolled subjects was 6.25%, and 30.3% for a comparable population from the National Burn Repository (P < .05). Engraftment was 83.5 ± 2.0% for ESS and 96.5 ± 0.9% for AG. Percentage TBSA closed was 29.9 ± 3.3% for ESS, and 47.0 ± 2.0% for AG. These values were significantly different between the graft types. Correlation of % TBSA closed with ESS with % TBSA full-thickness burn generated an R value of 0.65 (P < .001). These results indicate that autologous ESS reduce mortality and requirements for donor skin harvesting, for grafting of full-thickness burns of greater than 50% TBSA.


Subject(s)
Burns/pathology , Burns/surgery , Skin Transplantation/methods , Skin, Artificial/statistics & numerical data , Wound Healing/physiology , Adolescent , Biopsy, Needle , Body Surface Area , Child , Child, Preschool , Female , Follow-Up Studies , Graft Survival , Humans , Immunohistochemistry , Infant , Injury Severity Score , Male , Prospective Studies , Risk Assessment , Skin Transplantation/adverse effects , Survival Rate , Tissue and Organ Harvesting , Transplantation, Autologous , Treatment Outcome
3.
J Burn Care Res ; 37(4): 255-64, 2016.
Article in English | MEDLINE | ID: mdl-26056760

ABSTRACT

Pressure therapy has been considered standard, first-line intervention for the treatment of hypertrophic scars since its introduction in the 1960s. Although widely used, this scar management technique has historically been based on a wide array of anecdotal evidence as opposed to strong scientific support. Evidence has become more prevalent in recent years, necessitating a synthesis to develop an evidence-based clinical guideline. The clinical question was asked, "Among individuals with or at risk to develop active hypertrophic scars, does treatment with pressure therapy improve aesthetic and functional outcomes?" An evidence-based practice project was completed with aims to synthesize relevant literature to determine recommendations for the use of pressure therapy in individuals at risk for hypertrophic scars. A systematic search of the literature was conducted for the dates January 1950 to February 2014 of the following databases: MEDLINE, CINAHL, Cochrane Database for Systematic Reviews, Burntherapist.com, Cochrane Libraries, Ebsco, Google Scholar, OT Seeker, Ovid, MedLine, PEDro.org, Pubmed.gov, Pubmed Clinical Queries, and hand search of relevant articles through use of reference lists. Search terms included scar, hypertroph*, pressure therapy, compression therapy, pressure garment, burn, scald, trauma as well as MeSH terms cicatrix and hypertrophic. Articles were reviewed in terms of ability to answer the clinical question as well as strength of conclusions. A total of 45 articles were found and critiqued, 28 of which were relevant to the clinical question. Evidence strength ranged from level 1 to level 5. Results from the studies were synthesized to create clinical recommendations to guide treatment. Based on best available evidence, it is recommended that pressure therapy is utilized to decrease scar height and erythema that it is used for grafts and wounds requiring 14 to 21 days to heal, for 23 hours/day for 12 months, fit to achieve 20 to 30 mm Hg of pressure, fit by a skilled technician, and replaced every 2-3 months. In addition, it is not recommended that pressure therapy is used to treat abnormal pigmentation, nor used to hasten scar maturation. This literature search revealed insufficient evidence addressing the impact of pressure therapy on scar pliability. Among individuals with or at risk to develop active hypertrophic scars, treatment with pressure therapy does improve outcomes, particularly for aesthetic concerns including scar thickness and erythema. Applicability of research to practice: The practical treatment recommendations presented may improve consistency and efficacy of pressure therapy utilization at the point of care.


Subject(s)
Burns/therapy , Cicatrix, Hypertrophic/therapy , Compression Bandages , Evidence-Based Medicine , Erythema/prevention & control , Humans , Pressure , Wound Healing
4.
J Hand Surg Am ; 40(7): 1477-84; quiz 1485, 2015 Jul.
Article in English | MEDLINE | ID: mdl-26043803

ABSTRACT

Despite contributing a small percentage to the total body surface area, hands are the most commonly burned body part and are involved in over 90% of severe burns. Although the mortality of isolated hand burns is negligible, morbidity can be substantial given our need for functioning hands when performing activities of daily living. The greatest challenges of treating hand burns are 2-fold. First, determining the depth of injury can be difficult even for the most experienced surgeon, but despite many diagnostic options, clinical examination remains the gold standard. Second, appropriate postoperative hand therapy is crucial and requires a multidisciplinary approach with an experienced burn surgeon, hand surgeon, and hand therapist. Ultimately, the goals of treatment should include preservation of function and aesthetics. In this review, we present an approach to the management of the acutely burned hand with discussion of both conservative and surgical options. Regardless of the initial treatment decision, subsequent care for this subset of patients should be aimed at preventing debilitating postburn scar contractures that can severely limit hand function and ultimately require reconstructive surgery.


Subject(s)
Burns/therapy , Hand Deformities, Acquired/therapy , Hand Injuries/therapy , Activities of Daily Living , Humans , Plastic Surgery Procedures
5.
J Hand Surg Am ; 39(3): 484-487.e2, 2014 Mar.
Article in English | MEDLINE | ID: mdl-24495625

ABSTRACT

We present 4 patients, 4 months to 10 years of age, with thoracic outlet syndrome. All were referred to the brachial plexus clinic. Three patients were diagnosed with vascular thoracic outlet syndrome after clinical evaluation and diagnostic imaging. Three had a cervical rib and 1 had an anomalous first rib. All patients were treated surgically through a supraclavicular approach and had resolution of the symptoms. No postoperative complications were noted.


Subject(s)
Thoracic Outlet Syndrome/diagnosis , Thoracic Outlet Syndrome/surgery , Child , Diagnosis, Differential , Female , Humans , Infant , Male , Treatment Outcome
6.
J Burn Care Res ; 35(2): 143-7, 2014.
Article in English | MEDLINE | ID: mdl-24445373

ABSTRACT

Existing practice guidelines designed to minimize invasive catheter infections and insertion-related complications in general intensive care unit patients are difficult to apply to the burn population. Burn-specific guidelines for optimal frequency for catheter exchange do not exist, and great variation exists among institutions. Previously, the authors' practice was to follow a new site insertion at 48 hours by an exchange over a guidewire, which was followed 48 hours later by a second guidewire exchange (48h group). As a performance improvement initiative, the authors attempted to determine whether there would be any advantage or disadvantage to extending these intervals to 72 hours (72h). All patients with centrally placed intravascular catheters from October 2007 to August 2008 were included in the 48h group, and all patients with catheters placed from September 2008 to December 2009 comprised the 72h group. Catheter infection rates were determined using the National Healthcare Safety Network definition for central line-associated bloodstream infections (CLABSIs) and calculated as CLABSIs/1000 catheter days. The two groups were not significantly different for age, sex, burn etiology, total burn size, or percent third-degree burn. There were 3.1 CLABSIs/1000 catheter days for the 48h group and 2.8 CLABSIs/1000 catheter days for the 72h group (NS). The authors conclude that increasing the central catheter change interval from 48 to 72 hours did not result in any increase in their CLABSI rate. Implementation of this change in practice is expected to decrease supply costs by $28,000 annually in addition to reducing clinical support services needed to perform these procedures.


Subject(s)
Bacteremia/prevention & control , Burns/complications , Catheter-Related Infections/prevention & control , Catheterization, Central Venous , Infection Control/methods , Quality Improvement , Bacteremia/epidemiology , Catheter-Related Infections/epidemiology , Child , Female , Humans , Male , Ohio/epidemiology , Time Factors
7.
Ann Plast Surg ; 72(2): 150-4, 2014 Feb.
Article in English | MEDLINE | ID: mdl-24149411

ABSTRACT

BACKGROUND: This study is a 10-year follow-up to our previous publication reviewing the complication rates of tissue expansion in the pediatric burn population. The purpose of this study was to determine if our institutional experience with tissue expanders had remained stable during the subsequent 10 years. METHODS: There were 240 patients who were identified at a major pediatric burn center who underwent reconstruction with a tissue expander (256 tissue expanders) from 1996 to 2006. Data were obtained retrospectively by reviewing patient medical records. Complications were categorized into absolute and relative complications. RESULTS: Absolute complications occurred in 36 (14.1%) of 256 expanders placed and relative complications occurred in 26 (10.2%) of 256 expanders placed. There was no statistical difference between this study and our previous study for overall complication rates and complications for all sites. The highest complication rate occurred when the scalp was a surgical site. Betadine skin preparation was associated with a 10% reduction in infection-related complications compared to other skin preparations. The operating surgeon or age of patient was not found to be associated with increased complication rates. CONCLUSIONS: After changing our tissue expander protocol, the complication rates at our institution have remained stable during the 10-year follow-up period. Tissue expansion in the pediatric burn population continues to be a safe and effective reconstructive option with acceptable complication rates.


Subject(s)
Burns/surgery , Postoperative Complications/prevention & control , Tissue Expansion/methods , Adolescent , Algorithms , Child , Child, Preschool , Clinical Protocols , Decision Support Techniques , Follow-Up Studies , Humans , Infant , Postoperative Complications/epidemiology , Postoperative Complications/etiology , Retrospective Studies , Tissue Expansion/instrumentation , Tissue Expansion Devices , Treatment Outcome , Young Adult
8.
Article in English | MEDLINE | ID: mdl-27252955

ABSTRACT

PURPOSE: Constriction band syndrome afflicting in utero development can lead to devastating and possibly fatal outcomes. A lack of consensus regarding noninvasive testing and surgical modalities is likely secondary to the continued poorly understood pathology. Methods : We provide a case report of a 6-month-old boy who presented with a functional, nonsensate upper limb after surgical release of midhumeral banding at 3 months of age. RESULTS: Exploration revealed intact, albeit atrophic, peripheral nerves with brachial artery disruption above the elbow. Sural nerve grafting was performed and 2-year follow-up demonstrated return of protective sensation in the median nerve distribution with minimal motor return. CONCLUSION: This case demonstrates that nerves present distal to the original soft tissue insult oppose the idea of failure of nerve formation. Early nerve grafting at the time of initial Z-plasty release may serve to improve long-term functional outcomes.

9.
Dermatol Surg ; 38(9): 1490-6, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22672578

ABSTRACT

BACKGROUND: The pulsed-dye laser (PDL) is a potential adjunctive therapy for treatment of hyperemic and hypertrophic scars. OBJECTIVE: To compare the effects of early PDL treatment plus compression therapy (CT) with those of CT alone in patients undergoing burn scar reconstruction with split-thickness grafts on an extremity. METHODS: Laser treatments were applied to one half of the graft seam. Standard CT was applied to both halves. Laser treatment was repeated at 6-week intervals until one half reached sufficient clinical improvements. Each half was evaluated just before treatments using quantitative measures of color, scar height, biomechanical properties and clinical features using the Vancouver Scar Scale (VSS). RESULTS: Less quantitative scar erythema and height and greater tissue elasticity were observed after two or three treatments for PDL plus compression than with compression alone. VSS scores showed greater improvement for vascularity, pliability, pigmentation, and height for PDL plus compression than for compression alone. CONCLUSION: PDL treatment in combination with CT appears to reduce scar hyperemia and height and normalize the biomechanical properties of burn-related scars.


Subject(s)
Cicatrix/pathology , Cicatrix/therapy , Compression Bandages , Lasers, Dye/therapeutic use , Adolescent , Adult , Burns/complications , Child , Cicatrix/physiopathology , Combined Modality Therapy , Elasticity , Erythema/therapy , Female , Humans , Male , Pliability , Severity of Illness Index , Single-Blind Method , Skin/pathology , Skin/physiopathology , Skin Transplantation , Young Adult
10.
J Burn Care Res ; 32(4): e146-8, 2011.
Article in English | MEDLINE | ID: mdl-21747331

ABSTRACT

Intracranial injury has been reported secondary to not only blunt and penetrating trauma but also thermal and high-voltage electrical injury. Reconstruction can be challenging, especially in the face of necrosis of large areas of the cranium. The authors present a novel case of fourth-degree thermal burn to the head caused by a rotating tire. Initial wound debridement exposed dura, prompting a dural patch and Integra® for temporary coverage. Definitive coverage was accomplished with a latissimus dorsi free flap. The injury was complicated by associated neurologic defects and seizure activity. However, management was effective, and at 1 year, the patient is alive and well.


Subject(s)
Burns, Electric/surgery , Chondroitin Sulfates/therapeutic use , Collagen/therapeutic use , Dura Mater/injuries , Dura Mater/surgery , Scalp/surgery , Adult , Humans , Intracranial Hemorrhages/surgery , Male , Plastic Surgery Procedures/methods , Scalp/pathology , Skin Transplantation/methods , Sports
11.
J Burn Care Res ; 32(3): 410-4, 2011.
Article in English | MEDLINE | ID: mdl-21422941

ABSTRACT

Thrombocytopenia is initially seen in patients with burn injury as a transient occurrence during the first week after injury. Subsequent decreases occur later in the course of treatment and are commonly due to sepsis, dilutional effects, and medication exposure. Although studies have demonstrated that thrombocytopenia in the critically ill patients is associated with a worse prognosis, there is limited literature as to the significance of thrombocytopenia in the pediatric burn patients. In this study, the authors evaluate the prognostic implications of thrombocytopenia in the pediatric burn patients. They performed a 5-year retrospective chart of patients aged 18 years or younger with burns >20% TBSA admitted to their institution. Data collected included patient demographics, burn etiology and %TBSA involvement, length of stay, pertinent laboratory values, and in-hospital morbidity and mortality. Of the 187 patients studied, thrombocytopenia occurred in 112 patients. Eighty-two percent demonstrated thrombocytopenia within the first week of injury and 18% demonstrated additional episodes of thrombocytopenia after this time. A reactive thrombocytosis occurred in 130 (70%) patients. The incidence of thrombocytopenia could not be attributed to age, gender, or burn etiology. However, patients with thrombocytopenia were more likely to have inhalation injury and extensive TBSA involvement than those without (P < .05). Sepsis was the cause of significant thrombocytopenia after the first week of hospitalization. Of the 187 patients, 14 died (7%). The incidence of thrombocytopenia in survivors and nonsurvivors was statistically significant in that nonsurvivors demonstrated a more profound drop in platelet count during the first week after injury and had a more depressed platelet recovery curve than survivors. The authors conclude that the early development of thrombocytopenia with depressed thrombocytosis in the pediatric burn patient is associated with increased mortality risk and is influenced by the extent of burn, inhalation injury, and the development of sepsis.


Subject(s)
Burns/diagnosis , Burns/epidemiology , Thrombocytopenia/diagnosis , Thrombocytopenia/epidemiology , Adolescent , Age Distribution , Burn Units , Burns/therapy , Child , Child, Preschool , Cohort Studies , Comorbidity , Female , Humans , Incidence , Injury Severity Score , Platelet Count , Prognosis , Retrospective Studies , Risk Assessment , Sex Distribution , Survival Rate , Thrombocytopenia/therapy
12.
J Burn Care Res ; 30(4): 657-60, 2009.
Article in English | MEDLINE | ID: mdl-19506501

ABSTRACT

Methicillin-resistant Staphylococcus aureus (MRSA) is becoming more predominant in the community. We have seen increasing cases of furunculitis in our outpatient burn clinic, which appear to develop weeks after the initial burn injury and in patients with limited inpatient stays. We performed a 3-year retrospective review of all outpatient burn patients who developed furunculitis. Data analyzed included length of hospital stay, type of injury sustained, culture and sensitivity results, and treatment provided. A total of 28 patients were identified with MRSA furunculitis, which presented as painful, hard, indurated boils with minimal purulent drainage. Adults had less extensive burn injuries (mean of 12% TBSA adults vs 20% TBSA children) with shorter hospital stays (mean 8 days adults vs 22 days children). Fifty-seven percent of the patients had multiple furuncules, involving both burned and nonburned areas. Patients with furunculitis had a less resistant MRSA strain than those without furunculitis. Of the 22 patients who received systemic antibiotic coverage, 14 (58%) were successfully treated with 1 antibiotic regimen, whereas 8 (33%) required multiple antibiotics. In this study, furunculitis in the outpatient setting was believed to be consistent with community-acquired MRSA. Incision and drainage was not sufficient in patients with multiple furuncles, and systemic antibiotics were administered. Through increased awareness of the prevalence of community-acquired MRSA in the community, appropriate antibiotic treatment can be initiated, and the discomfort and transmission risk associated with this disease can be minimized.


Subject(s)
Burns/microbiology , Cross Infection/epidemiology , Cross Infection/microbiology , Furunculosis/epidemiology , Furunculosis/microbiology , Staphylococcal Skin Infections/epidemiology , Adult , Anti-Bacterial Agents/therapeutic use , Child , Cross Infection/drug therapy , Female , Furunculosis/drug therapy , Humans , Length of Stay/statistics & numerical data , Male , Methicillin-Resistant Staphylococcus aureus , Ohio/epidemiology , Retrospective Studies , Staphylococcal Skin Infections/drug therapy , Statistics, Nonparametric , Treatment Outcome
13.
Ann Plast Surg ; 60(3): 283-7, 2008 Mar.
Article in English | MEDLINE | ID: mdl-18443510

ABSTRACT

BACKGROUND: Children with giant congenital nevomelanocytic nevi (CNN) are referred to our pediatric burn center for the surgical management of this disfiguring and potentially malignant skin disorder. Use of tissue expanders has contributed significantly in limiting donor site morbidity associated with treatment of giant CNN. Cultured skin substitutes (CSS) have also shown promise as an alternative wound coverage. With recent controversy regarding the effectiveness of excision in preventing melanoma risk, we wished to review our surgical management of giant CNN and to determine the incidence of malignancy in these patients. METHODS: A retrospective chart review of patients with giant CNN was performed from 1985 to 2003. Charts were reviewed for age, sex, percentage total body surface area (TBSA) involved, age at initiation and completion of treatment, surgical treatment, complications, histopathology, and length of follow-up. RESULTS: Of the 40 patients treated at our facility, the mean extent of skin involvement was 10% TBSA (range: 0.5%-75%). The mean age at initial operation was 5.1 years, and the majority of surgical interventions were completed within a mean of 1.3 years. Twenty-two patients (55%) required more than 1 surgical procedure. Excision and split-thickness skin grafting was the most common surgical procedure (n = 22) followed by excision with primary closure (n = 18). Ten patients were treated with tissue expansion, while 4 received cultured skin replacements. One patient died of extracutaneous melanoma during the course of surgical treatment. Three patients demonstrated histopathologic evidence of cytoatypia but remained clinically free of malignancy during a mean follow-up of 11 years. CONCLUSIONS: Giant CNN are both important cosmetic and medical problems. With an associated lifetime risk of melanoma in 4%-10% of patients, excision of CNN is recommended despite the fact that 50% of melanomas arise extracutaneously. Depending on the extent of body surface area involvement, wound closure can be obtained with conventional split- or full-thickness skin grafts, tissue expansion, and/or cultured autologous cultured skin substitutes. The latter 2 modalities provide improved cosmetic results, with minimal donor site morbidity.


Subject(s)
Nevus, Pigmented/congenital , Nevus, Pigmented/surgery , Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Retrospective Studies , Skin Transplantation
14.
J Trauma ; 60(4): 821-9, 2006 Apr.
Article in English | MEDLINE | ID: mdl-16612303

ABSTRACT

BACKGROUND: Rapid and effective closure of full-thickness burn wounds remains a limiting factor in burns of greater than 50% of the total body surface area (TBSA). Hypothetically, cultured skin substitutes (CSS) consisting of autologous cultured keratinocytes and fibroblasts attached to collagen-based sponges may reduce requirements for donor skin, and morbidity from autograft harvesting and widely-meshed skin grafts. METHODS: To test this hypothesis, CSS were prepared from split-thickness skin biopsies collected after enrollment of 40 burn patients by informed consent into a study protocol approved by the local Institutional Review Boards of three participating hospitals. CSS and split-thickness skin autograft (AG) were applied in a matched-pair design to patients with full-thickness burns involving a mean value of 73.4% of the TBSA. Data collection consisted of photographs, area measurements of donor skin and healed wounds after grafting, qualitative outcome by the Vancouver Scale for burn scar, and biopsies of healed skin. RESULTS: Engraftment at postoperative day (POD) 14 was 81.5 +/- 2.1% for CSS and 94.7 +/- 2.0 for AG. Percentage TBSA closed at POD 28 was 20.5 +/- 2.5% for CSS, and 52.1 +/- 2.0 for AG. The ratio of closed to donor areas at POD 28 was 66.2 +/- 8.4 for CSS, and 4.0 +/- 0.0 for each harvest of AG. Each of these values was significantly different between the graft types. Correlation of percent TBSA closed with CSS at POD 28 with percent TBSA full-thickness burn generated an r value of 0.37 (p < 0.0001). Vancouver Scale scores at 1 year after were not different for erythema, pliability, or scar height, but pigmentation remained deficient in CSS. CONCLUSIONS: These results demonstrate that CSS reduce requirements for donor skin harvesting for grafting of excised, full-thickness burns of greater than 50% TBSA with qualitative outcome that is comparable to meshed AG. Availability of CSS for treatment of extensive, deep burns may reduce time to wound closure, morbidity, and mortality in this patient population.


Subject(s)
Burns/surgery , Skin Transplantation/methods , Skin/pathology , Adolescent , Burns/mortality , Burns/therapy , Child , Child, Preschool , Female , Humans , Infant , Male , Postoperative Care
15.
Surgery ; 138(4): 734-40; discussion 740-1, 2005 Oct.
Article in English | MEDLINE | ID: mdl-16269303

ABSTRACT

BACKGROUND: Hidradenitis suppurativa (HS) is a disease of the apocrine sweat glands resulting in chronic wounds with abscesses, sinuses, and fibrosis. Because many patients referred for treatment have both recurrent and progressive disability, we attempted to determine which factors have the greatest impact on outcome so we could develop an operative treatment algorithm. METHODS: We identified 57 patients with HS who underwent operative treatment for chronic recurrent HS from January 1994 through December 2003. Charts were reviewed for demographic, treatment, and outcome data. RESULTS: The mean age at presentation was 34 years and the average duration of symptoms was 6.7 years. Two thirds of the patients had undergone 1 or more incision and drainage procedures and 90% had received long-term antibiotic therapy. Axillary involvement was present in 88% of women and was bilateral in half of all patients. Inguinoperineal involvement was present in 87% of men and was bilateral in 92% of all patients. An algorithm for operative treatment was developed based on the extent of involvement, chronicity, and comorbid conditions. Ninety-two operative procedures were performed, 50% involved the axilla, 36% involved the perineum, and 14% involved the inguinal region. Excision and primary closure was used for localized disease; wide excision with or without skin grafting was used for diffuse disease. CONCLUSIONS: HS is a chronic relapsing disease that frequently causes disabling pain, diminished range of motion, and social isolation. Definitive treatment involves operative excision of the involved apocrine tissue and should be individualized based on the stage and location of the disease.


Subject(s)
Hidradenitis Suppurativa/surgery , Adult , Algorithms , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Apocrine Glands/surgery , Axilla/surgery , Drainage , Drug Administration Schedule , Female , Groin/surgery , Hidradenitis Suppurativa/drug therapy , Hidradenitis Suppurativa/physiopathology , Humans , Male , Perineum/surgery , Retrospective Studies , Skin Transplantation
16.
Ann Surg ; 235(2): 269-79, 2002 Feb.
Article in English | MEDLINE | ID: mdl-11807368

ABSTRACT

OBJECTIVE: Comparison of cultured skin substitutes (CSS) and split-thickness skin autograft (AG) was performed to assess whether donor-site harvesting can be reduced quantitatively and whether functional and cosmetic outcome is similar qualitatively in the treatment of patients with massive cutaneous burns. SUMMARY BACKGROUND DATA: Cultured skin substitutes consisting of collagen-glycosaminoglycan substrates populated with autologous fibroblasts and keratinocytes have been shown to close full-thickness skin wounds in preclinical and clinical studies with acceptable functional and cosmetic results. METHODS: Qualitative outcome was compared between CSS and AG in 45 patients on an ordinal scale (0, worst; 10, best) with primary analyses at postoperative day 28 and after about 1 year for erythema, pigmentation, pliability, raised scar, epithelial blistering, and surface texture. In the latest 12 of the 45 patients, tracings were performed of donor skin biopsies and wounds treated with CSS at postoperative days 14 and 28 to calculate percentage engraftment, the ratio of closed wound:donor skin areas, and the percentage of total body surface area closed with CSS. RESULTS: Measures of qualitative outcome of CSS or AG were not different statistically at 1 year after grafting. Engraftment at postoperative day 14 exceeded 75% in the 12 patients evaluated. The ratio of closed wound:donor skin areas for CSS at postoperative day 28 was significantly greater than for conventional 4:1 meshed autografts. The percentage of total body surface area closed with CSS at postoperative day 28 was significantly less than with AG. CONCLUSIONS: The requirement for harvesting of donor skin for CSS was less than for conventional skin autografts. These results suggest that acute-phase recovery of patients with extensive burns is facilitated and that complications are reduced by the use of CSS together with conventional skin grafting.


Subject(s)
Burns/surgery , Skin Transplantation , Skin, Artificial , Burns/physiopathology , Child , Female , Humans , Male , Transplantation, Autologous , Wound Healing
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