ABSTRACT
In order to develop novel compounds for topical use possessing antiallergic as well as antiinflammatory activities, a series of o-aminophenol derivatives bearing H1-antihistaminic structures were synthesized and their effects were investigated on lipid peroxidation in rat brain homogenates, antiinflammatory effection arachidonic acid- and 12-O-tetradecanoylphorbol-13- acetate-induced mouse ear edema and antiallergic effect on 48-h homologous passive cutaneous anaphylaxis in rats. Furthermore, the effects of these compounds on delayed-type hypersensitivity reaction in mice were examined. Several N-monosubstituted amino-4-methylphenols were found to exert potent inhibitory activities in all of these assays. Of these compounds, 4m was chosen for further development as AD0261.
Subject(s)
Aminophenols/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Histamine H1 Antagonists/pharmacology , Hypersensitivity, Delayed/drug therapy , Lipid Peroxidation/drug effects , Passive Cutaneous Anaphylaxis/drug effects , Administration, Topical , Aminophenols/administration & dosage , Aminophenols/chemical synthesis , Aminophenols/chemistry , Animals , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Antioxidants/chemical synthesis , Antioxidants/chemistry , Antioxidants/pharmacology , Arachidonic Acid/pharmacology , Brain/drug effects , Ear , Edema/drug therapy , Guinea Pigs , Histamine H1 Antagonists/administration & dosage , Histamine H1 Antagonists/chemical synthesis , Male , Mice , Mice, Inbred ICR , Rats , Rats, Sprague-Dawley , Skin Tests , Tetradecanoylphorbol Acetate/pharmacologyABSTRACT
We have used closed reduction based on Gillies' method using an original Y-shaped zygomatic elevator in 50 cases after radiographic evaluation of the displacement by three directional radiography. No patients had residual restriction of mandibular motion, double vision or facial asymmetry. Radiography showed poor reduction in two cases, and displacement of the initial reduction in three. In all other cases, satisfactory results were achieved.
