ABSTRACT
Renal transplant recipients are on long-term potent immunosuppressive therapy, which makes them highly vulnerable to opportunistic fungal infections. Dematiaceous, or dark-pigmented saprophytic fungi, are being increasingly seen as opportunistic pathogens of mycoses in immunosuppressed patients. One of these is Aureobasidium pullulans, which is a black yeast-like dematiaceous fungus found ubiquitously in the environment that can cause various opportunistic human infections. Most infections occur by traumatic inoculation, such as keratitis and cutaneous lesions; disseminated mycoses are very rare and occur only in severely immunocompromised patients. We report a case of disseminated fungal infection due to A. pullulans in a pediatric patient who underwent renal transplant. The use of voriconazole and vacuum-assisted closure along with surgical drainage most likely contributed to the patient's positive outcome.
Subject(s)
Ascomycota/isolation & purification , Immunocompromised Host , Kidney Transplantation , Mycoses/diagnosis , Opportunistic Infections/diagnosis , Adolescent , Female , Humans , Mycoses/immunology , Opportunistic Infections/immunologyABSTRACT
UNLABELLED: Bilateral obstructive nephrolithiasis is a rare cause of acute kidney injury (AKI) in early childhood. As soon as the identification of AKI secondary to ureteral stone is made, it will necessitate an emergency treatment. PATIENTS: We report three infants with AKI caused by bilateral obstructive ureteral cystine stones. They were diagnosed with acute post-renal injury due to obstructive bilateral ureteral stones based on ultrasound scan findings. Immediately, bilateral ureteral stents were inserted for urinary drainage. Once renal function recovered to normal, each patient underwent ureteroscopy and percutaneous nephrolithotomy at the same session. Cystinuria was diagnosed by stone analysis and increased urinary excretion of cystine. Patients were advised to maintain a high fluid intake and were treated with potassium citrate in addition to tiopronin. CONCLUSIONS: With these three cases we would like to emphasize the importance of urolithiasis in the differential diagnosis of acute renal failure in young children, since urolithiasis may only cause nonspecific symptoms in this population. An early diagnosis with prompt treatment and a close follow-up are the key for achieving the best long-term outcome in cystinuria.
Subject(s)
Acute Kidney Injury/diagnosis , Acute Kidney Injury/etiology , Cystinuria/complications , Cystinuria/diagnosis , Acute Kidney Injury/therapy , Anuria/diagnosis , Anuria/etiology , Anuria/therapy , Child, Preschool , Cystinuria/therapy , Diagnosis, Differential , Diuretics/therapeutic use , Female , Fluid Therapy , Humans , Infant , Potassium Citrate/therapeutic use , Tiopronin/therapeutic useABSTRACT
Pancreas transplantation is associated with significant urological complications. Urological complications can jeopardize the graft survival. We present a de novo nonneurogenic detrusor-sphincter dyscoordination in a pancreas and kidney transplanted case. We also report follow-up under conservative treatment.
