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J Toxicol Environ Health A ; 77(1-3): 125-32, 2014.
Article in English | MEDLINE | ID: mdl-24555653

ABSTRACT

The aim of this study was to determine the no-observable-adverse-effect concentration (NOAEC) for trichlorfon, an antiparasitic agent used in aquaculture, in Piractus mesopotamicus (pacu) using acetylcholinesterase (AChE) activity as an end point. Fish were exposed 24 h/d for 15 d to different concentrations of trichlorfon in tanks of water for which a curve of dissipation was previously determined. Analysis of trichlorfon in water and fish plasma using gas chromatography with electron capture detection (GC-ECD) enabled measurement of limit of detection (LOD) and limit of quantification (LOQ), respectively, to be 3 and 10 ppb. Thirty-six hours after trichlorfon dilution in water, the concentration was below the LOD, and data showed that plasma concentrations did not exceed the LOQ. Apart from the 6.25 µg/L, all concentrations of trichlorfon significantly inhibited plasma and brain AChE activity compared to controls. The AChE activity levels returned to control values in 7 d. These data may be useful to determine the concentration of trichlorfon that destroys parasites without producing adverse effects in fish.


Subject(s)
Acetylcholinesterase/metabolism , Anthelmintics/toxicity , Characidae/metabolism , Trichlorfon/toxicity , Animals , Anthelmintics/analysis , Anthelmintics/pharmacokinetics , Aquaculture , Biomarkers/metabolism , Brain/drug effects , Brain/enzymology , Chromatography, Gas , Dose-Response Relationship, Drug , Limit of Detection , Linear Models , No-Observed-Adverse-Effect Level , Trichlorfon/analysis , Trichlorfon/pharmacokinetics , Water/chemistry
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