1.
Angew Chem Int Ed Engl
; 51(23): 5679-82, 2012 Jun 04.
Article
in English
| MEDLINE
| ID: mdl-22517734
2.
J Am Chem Soc
; 132(39): 13666-8, 2010 Oct 06.
Article
in English
| MEDLINE
| ID: mdl-20822182
ABSTRACT
Direct C-4-selective addition of pyridine across alkenes and alkynes is achieved for the first time by nickel/Lewis acid cooperative catalysis with an N-heterocyclic carbene ligand. A variety of substituents on both alkenes and pyridine are tolerated to give linear 4-alkylpyridines in modest to good yields. The addition across styrene, on the other hand, gives branched 4-alkylpyridines. A single example of C-4-selective alkenylation is also described.