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J Hosp Infect ; 112: 37-41, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33766544

ABSTRACT

This study investigated the potential of olanexidine gluconate as environmental disinfectant against enveloped viruses in the suspension test and three non-porous surface tests. In the suspension test, olanexidine gluconate showed immediate virucidal activity. In addition, non-porous surface tests demonstrated that, although the immediate effect of aqueous formulations was weak, the final virucidal efficacy outcompeted that of ethanol for disinfection. Furthermore, the effectiveness of olanexidine gluconate persisted even after drying on environmental surfaces. This study demonstrated the potential usage of olanexidine gluconate formulations as an environmental disinfectant in the infection control of enveloped viruses.


Subject(s)
Biguanides/pharmacology , Disinfectants/pharmacology , Glucuronates/pharmacology , Infection Control/methods , Viral Envelope/drug effects , Viruses/drug effects , Biguanides/chemistry , Cell Line , Disinfectants/chemistry , Disinfection/standards , Environmental Microbiology , Glucuronates/chemistry , Humans , Microbial Sensitivity Tests , Viruses/classification
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