ABSTRACT
Two cases of median raphe cysts of the penis with melanosis are presented. The presence of melanocytes was observed in the lining of the cysts by light and electron microscopy. The possible mechanism of the embryological development of the cysts is discussed in the context of the published literature.
Subject(s)
Cysts/pathology , Melanosis/pathology , Penile Diseases/pathology , Child, Preschool , Cysts/congenital , Humans , Male , Melanosis/congenital , Penile Diseases/congenitalSubject(s)
Anti-Bacterial Agents/adverse effects , Minocycline/adverse effects , Niacinamide/adverse effects , Pemphigoid, Bullous/drug therapy , Pneumonia/chemically induced , Aged , Aged, 80 and over , Anti-Bacterial Agents/therapeutic use , Fatal Outcome , Humans , Male , Minocycline/therapeutic use , Niacinamide/therapeutic use , Pneumonia/pathology , Skin/drug effects , Skin/pathologyABSTRACT
A total of 20 patients involved in gastrointestinal surgery was treated with cefoxitin (CFX). Ten patients were treated for postoperative infections and the other 10 patients were given CFX to prevent postoperative infections. The following results were obtained: In 10 patients treated for postoperative infections, 5 responses were judged "excellent", 1 "good", 2 "fair", 1 "poor" and 1 "unknown". In 25 strains of bacteria isolated from these patients, 21 were eradicated, 3 were replaced and 1 was unknown. In 10 patients given CFX for prevention of postoperative infections, 9 were judged "excellent" and the remaining 1 "good". No side effects were observed in any of the patients treated with CFX.
Subject(s)
Cefoxitin/therapeutic use , Premedication , Surgical Wound Infection/drug therapy , Adult , Aged , Cefoxitin/administration & dosage , Cefoxitin/adverse effects , Drug Evaluation , Female , Gastrointestinal Diseases/surgery , Humans , Male , Middle Aged , Surgical Wound Infection/prevention & controlABSTRACT
Synthesis and turnover of histone I and II in normal rat liver and spleen were studied by Amberlite CG 50 column chromatography. Histone I was separated into three or four subfractions, each of which showed a different rate of incorporation of [3H]lysine. This was verified by a more shallow gradient chromatography developed by Kinkade and Cole [3] for very lysine-rich histone (F1), which showed tissue specific differences between liver and spleen in both the elution pattern and synthetic rates. These subfractions were distinguished from each other by dodecylsulphate electrophoresis. The turnover, or disassociation of histone I and II in chromatin was measured by double-labelling of normal rat liver with [3H] and [14C]lysine. A good correspondence was found between the synthesis and turnover patterns of individual histone I fractions, while the histone II synthesized was conserved for over a month. From consideration of the turnover in relation to the cell population of normal liver tissue, which consists of a very small fraction of growing cells and a very large fraction of resting ones, it was concluded that turnover of histone I must occur even in resting cells. When DNA synthesis in the spleen was completely inhibited by hydroxyurea, the synthesis of histone II was inhibited but that of histone I was only partially inhibited. The remaining synthesis seemed to occur in cells in the resting state. It was concluded tentatively, the continuous replacement of very lysine-rich histones of chromatin must occur even in resting cells in which DNA synthesis has ceased. The biological significance of disassociation of histones from chromatin was discussed.
