1.
Chem Commun (Camb)
; 52(47): 7462-5, 2016 Jun 14.
Article
in English
| MEDLINE
| ID: mdl-27159156
ABSTRACT
The catalytic Mannich reaction of α-substituted α-isocyanoacetates with ketimines has been investigated. A variety of imidazolines containing congested vicinal tetra-substituted stereocenters were obtained in excellent yields with high diastereo- and enantioselectivity using cinchona alkaloid amide/Ni(ii) and base catalysts.
2.
Chemistry
; 21(27): 9615-8, 2015 Jun 26.
Article
in English
| MEDLINE
| ID: mdl-25944609
ABSTRACT
A direct enantioselective vinylogous Mannich reaction of ketimines with γ-butenolide has been developed. Good yields and enantioselectivities were observed for the reaction of various ketimines by using a cinchona alkaloid amide/Zn(OTf)2 catalyst and Et3N. Both enantiomers of the products could be obtained by using pseudoenantiomeric chiral catalysts.