ABSTRACT
Basic embryological findings on the development of the temporomandibular joint have yet to be elucidated sufficiently. This experiment, was undertaken to find the standard time course of the development of the temporomandibular joint in rat fetuses. Serial frontal and sagittal sections of rat fetal heads (between 13.5 and 20.5 days post-conception [p.c.]) were examined microscopically. The condyle was recognized as a mesenchymal condensation at 14.5 days p.c., while the glenoid fossa was recognized at 15.5 days p.c. The mesenchymal condensation of the condyle had differentiated into chondrocytes by 16.5 days p.c., and endochondral ossification was recognized at 17.5 days p.c. The intramembranous ossification of the glenoid fossa was already recognized by 16.5 days p.c.; this started in the posterior region and progressed anteriorly between the zygomatic arch and the squamous part of the temporal bone. Ossification of the condyle had not been completed by 20.5 days p.c., a mass of hypertrophic chondrocytes remained in the center of the condylar head. The glenoid fossa was almost completely ossified by 19.5 days p.c. A coarse region of cells, reminiscent of apoptosis, was recognized in the region of the prospective superior joint space at 17.5 days p.c., and an actual joint space had formed by 18.5 days p.c. The inferior joint space was recognized at 19.5 days p.c. as a fissural cavity, but it was much narrower than its superior counterpart. The prospective meniscus was distinguished on the condylar surface at 17.5 days p.c. by the difference in the shape of its constituent cells. The results obtained here seem to be useful for further experiments and molecular biological studies.
