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Interleukin-28B polymorphisms and response of chronic hepatitis C patients from Indonesia to pegylated interferon/ribavirin treatment.
Wibowo, Bogi P; Wibawa, I D N; Utsumi, Takako; Mustika, Syifa; Amin, Mochamad; Wahyuni, Rury M; Kurniawan, Hendra; Hendrayana, Agus; Setiawan, Poernomo B; Yamani, Laura N; Yano, Yoshihiko; Hotta, Hak; Hayashi, Yoshitake; Lusida, Maria I.
J Clin Microbiol ; 52(6): 2193-5, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24696021

ABSTRACT

This study demonstrated that Indonesian patients with chronic hepatitis C (mostly ethnic Java people) mostly were infected with hepatitis C virus (HCV) genotype 1; however, they carried mainly the major genotypes of interleukin 28B (IL-28B) single nucleotide polymorphisms (SNPs) (rs12979860 CC, rs11881222 TT, rs8103142 AA, and rs8099917 TT), and they mostly achieved sustained virological responses to pegylated interferon/ribavirin treatment.


Subject(s)
Hepatitis C, Chronic/drug therapy , Interferon-alpha/therapeutic use , Interleukins/genetics , Ribavirin/therapeutic use , Adult , Aged , Female , Gene Frequency , Genotype , Humans , Indonesia , Interferons , Male , Middle Aged , Polymorphism, Single Nucleotide , Treatment Outcome
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