Effects on alimentary high-fat diet on thiol disulfide homeostasis in rats.

The effects of high-fat diet on the thiol disulfide homeostasis of rats were evaluated by activities of glutathione redox system functioning in the blood and liver. A short-term (30 days) high-fat diet inhibited activities of glutathione-dependent enzymes. High-fat loading for 90 days promoted the development of a compensatory response of the glutathione redox system and restoration of the thiol disulfide homeostasis. The compensatory processes in the glutathione system failed on day 180 of alimentary loading because of redox imbalance in the thiol disulfide metabolism.

Age-related differences in the degree of lipid peroxidation and state of antioxidant protection under the influence of alloxan.

Alloxan-induced hyperglycemia was accompanied by activation of lipid peroxidation processes with different degree of their completeness depending on the age of experimental animals. Lipid peroxidation in young animals mainly resulted in the formation of end-products, while in adult animals the initial stage of oxidation prevailed. Alloxan inhibited the enzymatic and nonenzymatic systems of antioxidant protection, which impaired adaptation and caused oxidative stress.

Effect of Maksar on antioxidant system in rats with type IIa alimentary hyperlipoproteinemia.

The development of type IIa alimentary hyperlipoproteinemia in rats was accompanied by changes in activity of glutathione-dependent enzymes, exhaustion of the reserves of antioxidant vitamins in the liver and blood, and intensification of lipid peroxidation. The hepatoprotective preparation Maksar obtained from far-eastern plants Maachia amurensis and containing natural biological antioxidants normalized blood lipid composition, corrected liver lipidosis, and improved the antioxidant defense system.