ABSTRACT
Thyroid cancer is the most common type of endocrine tumor. The TNM classification remains a standard for treatment determination and predicting prognosis in thyroid cancer. The genes modules associated with the progression of papillary thyroid carcinoma (PTC) were not clear. We applied a weighted gene co-expression network analysis (WGCNA) and differential expression analysis to systematically identified co-expressed gene modules and hub genes associated with PTC progression based on The Cancer Genome Atlas (TCGA) PTC transcriptome sequencing data. An independent validation cohort, GSE27155, was used to evaluate the preservation of gene modules. We identified two co-expressed genes modules associated with progression of PTC. Enrichment analysis indicated that the two modules were enriched in angiogenesis and extracellular matrix organization. DCN, COL1A1, COL1A2, COL5A2 and COL3A1 were hub genes in the co-expressed network. We systematically identified co-expressed gene modules and hub genes associated with PTC progression for the first time, which provided insights into the mechanisms underlying PTC progression and some potential targets for the treatment of PTC.
Subject(s)
Gene Regulatory Networks , Thyroid Cancer, Papillary/genetics , Thyroid Cancer, Papillary/pathology , Thyroid Neoplasms/genetics , Thyroid Neoplasms/pathology , Disease Progression , Female , Gene Expression Profiling/methods , Gene Expression Regulation, Neoplastic , Genetic Predisposition to Disease , High-Throughput Screening Assays , Humans , Male , Neoplasm Staging , Prognosis , Risk Factors , Thyroid Cancer, Papillary/diagnosis , Thyroid Neoplasms/diagnosisABSTRACT
Weathering & transporting and depositing processes may improve the quality of some natural low-quality jadeite through reaction with surrounding water fluids. But the mechanism of such water-rock reaction has not been known clearly to date. Applying microscopic Fourier transform infrared spectroscopy (Micro-FTIR), this paper carried out comparatively in-situ research of jadeites' mineral composition before and after water-rock reaction. The results show that water-rock reaction cannot impact jadeites in their major and minor element composition, but greatly change their water content. Jadeites became richer, with even several times increase, in water content, after experiencing water-rock reaction, and hence show a shift of absorption peak at 3 550 cm(-1) to higher frequency. The mineral crystals of these jadeites showed reglar variation in water content from core to edge, and these jadeites have more water in marginal area than in center area, being opposite to the change in water content in jadeite during high temperature and pressure metamorphic process, hence implying that there are different mechanism and shift direction for H+/OH of jadeite between high pressure metamorphic process and low temperature water-rock reaction. We think that this finding may contribute to understanding the behavior of water in jadeite during metamorphic process and the mechanism of jadeite quality improvement.
