ABSTRACT
It is easy to come into contact with cytotoxic drugs, by touching or inhaling small quantities of the drug-containing aerosols or dusts. Contact with cytotoxic drugs can cause immediate problems, such as dermatitis, dizziness, nausea, and headache. Studies suggest that repeated exposure to small amounts of the drugs many cause organ or chromosome damage, impaired fertility, and even cancer. The evidence is not conclusive, but an approach that will minimize the possible risks is needed.
Subject(s)
Antineoplastic Agents , Medical Waste Disposal , Medical Waste , Aerosols , Antineoplastic Agents/toxicity , Dust , Guidelines as Topic , Humans , Medical Waste Disposal/methods , Occupational Exposure/prevention & control , Risk , SewageABSTRACT
In principle, the following three steps are considered for by-pass surgery; I. A gastric tube is moved up to the retro-sternal or to the ante-thoracic position. A T-tube is the inserted in the mid position of the gastric tube for decompression and drainage. 2. A retention vinyl tube is inserted in to the excluded esophagus for the purpose of post infusion therapy and for evaluation of the therapy. 3. A Roux-Y anastomotic internal fistula is placed at the distal site of the excluded esophagus. As a plan for combined therapy, PANa-Oil bleomycin (oil bleomycin 30 mg, PANa 0.5 g) is the infused into the isolated esophagus after the by-pass operation and the clinical effect is evaluated by introducing a radiopaque medium into the excluded esophagus via an inserted vinyl tube. Such infusion therapy after by-pass surgery was given to 3 patients and in 1 patient it was very effective. This suggested a positive effect on survival in cases of non-resectable esophageal cancer without side effects.
