Serum galectin-3, but not galectin-1, levels are elevated in schizophrenia: implications for the role of inflammation.

BACKGROUND: Previous studies have reported that galectin-3 is involved in inflammatory processes in the central nervous system and that neuroinflammation may play a role in the pathogenesis of schizophrenia. However, the link between schizophrenia and various galectins is unclear. OBJECTIVE: The objective of the present study is to determine whether galectin, a well-known lectin protein that binds to µ-galactoside, is associated with chronic schizophrenia. METHODS: Thirty-six patients with schizophrenia and 36 healthy controls participated in this study. Schizophrenia symptoms were assessed using the Brief Psychiatry Rating Scale (BPRS). Serum galectin-1 and galectin-3 levels were evaluated using ELISA and compared between the participant groups. Correlation analyses were also performed to examine the relationship between BPRS scores and each galectin level. RESULTS: Serum galectin-3 levels were significantly higher in patients with schizophrenia than they were in controls (p = 0.009, d = 0.640); however, serum galectin-1 levels were not significantly different between the groups (p = 0.513). No significant correlation was identified between serum galectin-3 level and the total BPRS score; however, a significant positive correlation was found between the serum galectin-3 level and the positive symptom score of the BPRS (ρ = 0.355; p = 0.033). Additionally, a significant negative correlation was identified between serum galectin-3 levels and the negative symptom score of the BPRS (ρ = -0.387; p = 0.020). CONCLUSIONS: Given the high serum levels of galectin-3 found in patients with schizophrenia compared with that in controls, these findings may support the inflammation hypothesis of schizophrenia.

Plasma folate and homocysteine levels may be related to interictal "schizophrenia-like" psychosis in patients with epilepsy.

Genetic and clinical data suggest that folate and homocysteine may play a role in the pathogenesis of psychiatric disorders. The total plasma homocysteine level is a sensitive measure of a functional folate deficiency. We thus investigated whether a functional folate deficiency and/or elevated levels of plasma homocysteine may be related to interictal "schizophrenia-like" psychosis (interictal psychosis ) of epilepsy. We studied the plasma folate, vitamin B12, and homocysteine levels of 32 age- and sex-matched epileptic patients with or without interictal psychosis. Each group included 25 localization-related epilepsies and 7 generalized epilepsies. The epileptic patients with interictal psychosis had significantly lower folate levels and higher homocysteine levels than those without interictal psychosis. There were no significant differences in the vitamin B12 levels between the two groups. The present study suggests that low plasma folate and high plasma homocysteine levels may be related to the pathophysiology of interictal psychosis of epilepsy. In future studies, we should investigate whether folate supplementation, in addition to antipsychotics, might play a beneficial role in the treatment of interictal psychosis in epileptic patients. Furthermore, the present findings should be confirmed by prospective longitudinal studies in a larger group of patients with epilepsy.

Carbamazepine may trigger new-onset epileptic seizures in an individual with autism spectrum disorders: a case report.

We herein report a case of new-onset epileptic seizures induced by carbamazepine in an individual with autism spectrum disorders (ASD). We clinicians should bear in mind the possibility that epileptic seizures may possibly be either precipitated or exacerbated by carbamazepine especially in individuals with ASD.

The nucleus accumbens unit activities related to the emotional significance of complex environmental stimuli in freely moving cats.

To establish the functional role of the nucleus accumbens (ACC) in emotionally motivated behaviors, extracellular single or multiple units were recorded from the ACC under an unanesthetized, freely moving non-operant condition in 43 cats. Then neuronal and behavioral responses to stimuli such as tones, live small animals, a human, air puffs and so on were analyzed using a videotape monitoring method. A total of 98 units were recorded from the ACC, and 34 (34.7%) of them responded to some of the stimuli. Of the 34 responded units, 5 (15%) units responded to quiet approach-provoking stimuli (appetitive stimuli), and 29 (85%) units responded to escape- or defensive attack-provoking stimuli (aversive stimuli). Although most of the units responded in an individual item-specific manner, there was no unit reacted to both the appetitive and aversive stimuli. The neuronal responses were not related to any movement or locomotion. The results were compared with those with the amygdala, and their neuronal responsiveness were shown to be quite different from each other. Although the ACC appears to be involved in the central processing of emotional behavior in some way, the role was suggested to be entirely different from that of the amygdala.