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Biosci Biotechnol Biochem ; 70(10): 2501-7, 2006 Oct.
Article in English | MEDLINE | ID: mdl-17031036

ABSTRACT

Tienchi ginseng tea was prepared from stems and leaves of Tienchi ginseng which is a special product in China. The increase in systolic blood pressure (SBP) was significantly inhibited by the consumption of a 4% this tea solution as drinking water from the prehypertensive stage (6 weeks of age) in male stroke-prone spontaneously hypertensive rats (SHRSP). A similar intake from the hypertensive stage also showed an anti-hypertensive effect. In contrast, a similar intake had no effect on SBP of normotensive Wistar Kyoto rats. We found that the rhizome of Tienchi ginseng contained two types of saponin: 20(s)-protopanaxadiol (PPD) such as ginsenosides Rb(1) and Rd having a hypotensive effect, and 20(s)-protopanaxatriol (PPT) such as ginsenosides Rg(1) and Re having a hypertensive effect. In contrast, the tea sample contained PPD and gamma-aminobutyric acid (GABA), but no PPT. These results suggest that drinking this tea infusion would be useful for controlling hypertension.


Subject(s)
Antihypertensive Agents/pharmacology , Panax/chemistry , Plant Extracts/therapeutic use , Animals , Blood Pressure/drug effects , Ginsenosides/pharmacology , Phytotherapy/methods , Plant Leaves/chemistry , Plant Stems/chemistry , Rats , Rats, Inbred SHR , Rats, Wistar , Rhizome/chemistry , Saponins/analysis , Saponins/pharmacology , Tea
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