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INTRODUCTION: To investigate the possible roles of selected single-nucleotide gene polymorphisms (SNPs) of the activin A receptor type 2A (ACVR2A) gene in the pathogenesis of hypertensive disorders of pregnancy (HDP). METHODS: In this study, the six SNPs of the ACVR2A gene were analyzed by multiplex polymerase chain reaction (PCR) combined with next-generation sequencing methods in 186 HDP patients and 380 healthy pregnant women. Multivariate logistic regression analysis combined with 10,000 permutation tests was used to analyze the potential relationship between ACVR2A gene polymorphisms and HDP, especially its subset pre-eclampsia. RESULTS: Our findings showed that the rs1424954, rs1014064, rs1128919, and rs3768687 differed significantly between HDP patients and control group (p = 0.035, p = 0.035, p = 0.024 and p = 0.035, respectively), which remained significant after 10,000 permutation tests. In addition, rs1424954, rs1014064, rs1128919, rs3768687, rs3764955, and rs13430086 were all statistically significant among the PE patients compared with the controls (p = 0.013, p = 0.016, p = 0.018, p = 0.019, p = 0.024 and p = 0.029, respectively). The significance still existed after 10,000 permutation tests. DISCUSSION: ACVR2A gene polymorphisms may play a role in the pathogenesis of HDP and its subset PE.
Subject(s)
Activin Receptors, Type II/genetics , Genetic Predisposition to Disease , Hypertension, Pregnancy-Induced/genetics , Polymorphism, Single Nucleotide , Adult , Case-Control Studies , China , Female , Genotype , Haplotypes , High-Throughput Nucleotide Sequencing , Humans , Male , PregnancyABSTRACT
@#Objective To explore the intra- and inter-rater reliability of shear wave elastography (SWE) for the patellar tendon and quadriceps femoris stiffness.Methods From October to November, 2017, the stiffness of the patellar tendon and quadriceps femoris of 20 healthy men was measured by SWE, and measured again five days later. The results were evaluated with interclass correlation coefficient (ICC).Results For patellar tendon, ICC=0.79 in intra-rater and inter-rater; for rectus femoris, ICC=0.71 in intra-rater and 0.73 in inter-rater; for vastus lateralis muscle, ICC=0.84 in intra-rater and 0.74 in inter-rater; for vastus medialis,ICC=0.95 in intra-rater and 0.94 in inter-rater.Conclusion It is a reliable and repeatable method to measure the stiffness of patellar tendon and quadriceps femoris by SWE.
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Objective To investigate the prevalence of psychological violence against children by parents and to explore possible influencing factors.Methods In two primary schools from a city,located in the northeast part of China,1 164 parents of the pupils from grade 1 to 6,were anonymously surveyed by a self-administered questionnaire,to analyze the situation of psychological violence and influencing factors.Results Of the 1 164 parents,78.1％ reported that they practised psychological violence towards their children.Compared with girls,boys were more psychologically maltreated by their parents (81.3％ vs.74.7％,P＜0.01).Data from the multivariate logistic regression analysis indicated that following factors increased the risk of psychological violence against children:child being male (OR=1.684);initiated by the mother (OR=1.640),parents experiences of psychologically violent victimization (OR=2.064) during their childhood,supportive or tolerant attitudes towards corporal punishment (OR=2.618) from the parents,low awareness of the harmfulness of psychological violence against children (OR=1.666) of the parents,and lower social economic status (OR=1.745) of the family,etc.Conclusion Psychological violence experienced by the parents appeared very common.Prevention programs on psychological violence should be strengthened to increase the awareness of parents on this serious problem.
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Objective To investigate the prevalence of psychological violence against children by parents and to explore possible influencing factors.Methods In two primary schools from a city,located in the northeast part of China,1 164 parents of the pupils from grade 1 to 6,were anonymously surveyed by a self-administered questionnaire,to analyze the situation of psychological violence and influencing factors.Results Of the 1 164 parents,78.1％ reported that they practised psychological violence towards their children.Compared with girls,boys were more psychologically maltreated by their parents (81.3％ vs.74.7％,P＜0.01).Data from the multivariate logistic regression analysis indicated that following factors increased the risk of psychological violence against children:child being male (OR=1.684);initiated by the mother (OR=1.640),parents experiences of psychologically violent victimization (OR=2.064) during their childhood,supportive or tolerant attitudes towards corporal punishment (OR=2.618) from the parents,low awareness of the harmfulness of psychological violence against children (OR=1.666) of the parents,and lower social economic status (OR=1.745) of the family,etc.Conclusion Psychological violence experienced by the parents appeared very common.Prevention programs on psychological violence should be strengthened to increase the awareness of parents on this serious problem.
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@#Objective To assess the reliability of strength of shoulder rotator cuff using a hand-held dynamometer among subjects with spinal cord injury. Methods 20 spinal cord injury subjects without shoulder pain participated in this study. A hand-held dynamometer was used to assess the strength of shoulder rotator cuff. Two therapists (A/B) obtained the strength of shoulder rotator cuff. One of the therapists assessed again 5days later. The intra- and inter-reliability (ICC) of strength of shoulder rotator was calculated. Results The strength of rotator cuff was assessed by the hand-held dynamometer. The intra-reliability of external and internal muscle strength was 0.94 and 0.95, respectively. The inter-reliability was 0.91 and 0.93, respectively. Conclusion A hand-held dynamometer is a feasible and reliable tool to assess the strength of rotator cuff among subjects with spinal cord injury.
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Objective:To investigate the prevalence of physical violence against children (PVAC)by parents and to explore possible related factors.Methods:In two primary schools in Liaoning Province,1164 parents of pupils in grade 1 to 6 were surveyed by a self-administered questionnaire anonymously to analyze situation about PVAC and related factors.PVAC was defined as having one or more following parent-to-child behaviors in the past three months:push,or shook a child;pinch,screw,or scratch a child;hit child's buttocks with hand;hit child's hand,foot,arm,leg or back with hand;hit child's buttocks with an object;hit child's face or head with hand;hit elsewhere (not buttocks)with an object;kicked a child with a foot or hit with a fist.Results:Of 1164 parents,53.1% reported that they had minor PVAC (51.0%)or/and severe PVAC (19.8%).Multivariate logistic regres-sion analysis indicated that following factors increased the risk of PVAC:child's male gender (OR =1.49),younger age of children (OR =1.38),poor school performance of children (OR =1.85 ),mother (OR =2.09),parents'childhood physical violence victimization experiences (OR =1.53),parents'supportive or tolerant attitudes towards corporal punishment (OR =3.15),parents'lower awareness of the harmfulness of physical violence against children (OR =2.31),and lower social economic status (OR =1.47).Conclusion:The PVAC by their parents may be com-mon in the present study.Parents'supportive or tolerant attitudes toward corporal punishment and low awareness of the harmfulness of physical violence is the main risk factors of PVAC.
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Objective To assess the reliability of strength of shoulder rotator cuff using a hand-held dynamometer among subjects with spinal cord injury. Methods 20 spinal cord injury subjects without shoulder pain participated in this study. A hand-held dynamometer was used to assess the strength of shoulder rotator cuff. Two therapists (A/B) obtained the strength of shoulder rotator cuff. One of the therapists assessed again 5days later. The intra-and inter-reliability (ICC) of strength of shoulder rotator was calculated. Results The strength of rota-tor cuff was assessed by the hand-held dynamometer. The intra-reliability of external and internal muscle strength was 0.94 and 0.95, respec-tively. The inter-reliability was 0.91 and 0.93, respectively. Conclusion A hand-held dynamometer is a feasible and reliable tool to assess the strength of rotator cuff among subjects with spinal cord injury.
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Objective To investigate the reliability of the morphologic measure of the iliotibial band (ITB) with musculoskeletal ultra-sound imaging. Methods 20 healthy young subjects were measured with the musculoskeletal ultrasound imaging of the thickness of bilateral ITB at the levels of the femoral condyle by 2 testers, and one of the testers measured again 3-5 days later. The intraclass correlation coeffi-cient (ICC) and minimum detectable change (MDC) were calculated, and the thickness of ITB in both sides was compared. Results The ICC of test-retest was 0.89 (R) and 0.85 (L), and it was 0.82 (R) and 0.84 (L) of inter-testers. The MDC was 0.41-0.51 mm. There was no signifi-cant different between right and left sides for the ITB thickness among healthy subjects (P=0.97). Conclusion Musculoskeletal ultrasound imaging is a feasible and reliable to measure the ITB thickness among young healthy subjects.
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@#Objective To investigate the reliability and validity of the E-LINK system for measuring hand strength. Methods 25 healthy adults were recruited to measure the strength of hand using E-LINK system and Jamar respectively. They were measured again 5 d later. Results The intra- and inter-rater reliability of hand strength measurement was satisfactory (ICC>0.75), as well as validity ( Pearson r>0.75, P<0.01). Conclusion E-LINK system can measure hand strength well.
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@#Objective To observe the effect of hot spring hydrotherapy and routine rehabilitation on spasticity of patients with incomplete thoracic spinal cord injury (SCI). Methods 25 patients with incomplete thoracic SCI were divided into hydrotherapy group (n=15) and control group (n=10). The hydrotherapy group received both routine rehabilitation and hydrotherapy，and the control group only underwent routine rehabilitation．They were evaluated with Modified Ashworth Scale (MAS) before and after treatment. Results There was a significant reduction on MAS in both the groups after treatment (P<0.01), and it was more in the hydrotherapy group (P<0.05). Conclusion The hot spring hydrotherapy can facilitate the release of spasticity after incomplete thoracic SCI.
