1.
Org Lett
; 22(19): 7508-7512, 2020 10 02.
Article
in English
| MEDLINE
| ID: mdl-32945684
ABSTRACT
Synthesis of optically active gem-difluorinated organic molecules attracts a great deal of interest due to their unique properties in pharmaceutical and agrochemical areas. Herein, a series of enantioenriched α,α-difluoro-ß-arylbutanoic esters were prepared in high yields (83-99%) with moderate to excellent enantioselectivities (≤97:3 er) by palladium-catalyzed asymmetric hydrogenation.