Exploring genotype-phenotype relationships of the CRABP2 gene on growth traits in beef cattle.

Cellular retinoic acid binding protein 2 (CRABP2) is essential to myoblast differentiation. However, there was no report about the function of CRABP2 gene in cattle. This study explored the association of CRABP2 gene polymorphisms with growth traits in cattle breeds by several methods, such as DNA sequencing, PCR, PCR-RFLP and forced PCR-RFLP. Two sequence variants were determined. There were 621 individuals in six cattle breeds from China for the experiment, and three breeds were used to test validation of polymorphisms and extent of linkage disequilibrium (LD). The results showed that both SNPs (SNP1, g.2458 G > T, SNP2, g.3878 G > A) were in intron1. Two SNPs were in low linkage disequilibrium. Association analysis suggested that SNP1 had the significant difference on growth traits with body height, height at hip cross and body slanting length (P < .05), while SNP2 showed a significant difference in growth traits with body height, height at hip cross and body slanting length(P < .05). The results of this investigation displayed that the CRABP2 gene is an available candidate gene and may be used for breed selection and conservation.

The Channel Matters: Self-disclosure, Reciprocity and Social Support in Online Cancer Support Groups.

People with health concerns go to online health support groups to obtain help and advice. To do so, they frequently disclose personal details, many times in public. Although research in non-health settings suggests that people self-disclose less in public than in private, this pattern may not apply to health support groups where people want to get relevant help. Our work examines how the use of private and public channels influences members' self-disclosure in an online cancer support group, and how channels moderate the influence of self-disclosure on reciprocity and receiving support. By automatically measuring people's self-disclosure at scale, we found that members of cancer support groups revealed more negative self-disclosure in the public channels compared to the private channels. Although one's self-disclosure leads others to self-disclose and to provide support, these effects were generally stronger in the private channel. These channel effects probably occur because the public channels are the primary venue for support exchange, while the private channels are mainly used for follow-up conversations. We discuss theoretical and practical implications of our work.

Seekers, Providers, Welcomers, and Storytellers: Modeling Social Roles in Online Health Communities.

Participants in online communities often enact different roles when participating in their communities. For example, some in cancer support communities specialize in providing disease-related information or socializing new members. This work clusters the behavioral patterns of users of a cancer support community into specific functional roles. Based on a series of quantitative and qualitative evaluations, this research identified eleven roles that members occupy, such as welcomer and story sharer. We investigated role dynamics, including how roles change over members' lifecycles, and how roles predict long-term participation in the community. We found that members frequently change roles over their history, from ones that seek resources to ones offering help, while the distribution of roles is stable over the community's history. Adopting certain roles early on predicts members' continued participation in the community. Our methodology will be useful for facilitating better use of members' skills and interests in support of community-building efforts.

Self-disclosure and Channel Difference in Online Health Support Groups.

Online health support groups are places for people to compare themselves with others and obtain informational and emotional support about their disease. To do so, they generally need to reveal private information about themselves and in many support sites, they can do this in public or private channels. However, we know little about how the publicness of the channels in health support groups influence the amount of self-disclosure people provide. Our work examines the extent members self-disclose in the private and public channels of an online cancer support group. We first built machine learning models to automatically identify the amount of positive and negative self-disclosure in messages exchanged in this community, with adequate validity (r>0.70). In contrast to findings from non-health-related sites, our results show that people generally self-disclose more in the public channel than the private one and are especially likely to reveal their negative thoughts and feelings publicly. We discuss theoretical and practical implications of our work.

Commitment of Newcomers and Old-timers to Online Health Support Communities.

For online communities to be successful, they must retain an adequate number of members who contribute to the community. The amount and type of communication members receive can play an important role in generating and sustaining members' commitment to it. However, the communication that members find valuable may change with their tenure in the community. This paper examines how the communication members receive in an health-support community influences their commitment and how this influence changes with their tenure in the community. Commitment was operationalized with three measures: self-reported attachment, continued participation in the community, and responding to others. Results show that receiving communication was generally associated with increased commitment across the three measures, with its impact increasing with members' tenure. However, the average amount of informational and emotional support members received per message was associated with decreased commitment. Results have implications for interventions to encourage members' commitment to their communities throughout their history in the community.