Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 174
Filter
1.
Micromachines (Basel) ; 15(5)2024 May 10.
Article in English | MEDLINE | ID: mdl-38793214

ABSTRACT

In laser beam processing, the angle or offset between the auxiliary gas and the laser beam axis have been proved to be two new process optimization parameters for improving cutting speed and quality. However, a traditional electromechanical actuator cannot achieve high-speed and high-precision motion control with a compact structure. This paper proposes a magnetic levitation actuator which could realize the 5-DOF motion control of a lens using six groups of differential electromagnets. At first, the nonlinear characteristic of a magnetic driving force was analyzed by establishing an analytical model and finite element calculation. Then, the dynamic model of the magnetic levitation actuator was established using the Taylor series. And the mathematical relationship between the detected distance and five-degree-of-freedom was determined. Next, the centralized control system based on PID control was designed. Finally, a driving test was carried out to verify the five-degrees-of-freedom motion of the proposed electromagnetic levitation actuator. The results show it can achieve a stable levitation and precision positioning with a desired command motion. It also proves that the proposed magnetic levitation actuator has the potential application in an off-axis laser cutting machine tool.

2.
Rev Sci Instrum ; 95(5)2024 May 01.
Article in English | MEDLINE | ID: mdl-38717265

ABSTRACT

Magnetic flux leakage (MFL) technology is remarkable for its capability to detect pipeline geometric deformation and general corrosion defects. However, it cannot characterize the MFL behavior in stress-concentrated areas, thereby greatly challenging the subsequent pipeline maintenance. This study suggests that the MFL characteristics of pipeline in stress-concentrated areas are caused by the combined effect of the face magnetic charge on the deformed end-face and the body magnetic charge of the dislocation stack. In addition, an improved force-magnetic coupling model of the pipeline in stress-concentrated areas is established based on the magnetic dipole model and Jiles-Atherton (J-A) theory. In the verification experiment, the Q235 steel plate is magnetized along the extension direction (axis of the pipeline) through the solenoid coil to obtain the distribution law of the MFL signal in the stress-concentrated area under different excitation intensities. The results show that with the increase in excitation intensity, the deformation of the MFL field signal caused by the end-face of the stress-concentrated area gradually increases to a stable state. Moreover, the internal stress of the MFL field signal generated by the pipe dislocation rapidly increases to a peak value and then decays exponentially to a certain base value. The overall change trend is in good agreement with the calculation results of the established force-magnetic coupling model. Meanwhile, the differentiation research between deformation and internal stress MFL field signals under different magnetic field intensities can provide a reliable theoretical basis for the subsequent accurate identification and quantification of pipeline stress-concentrated areas.

3.
Sci Rep ; 14(1): 559, 2024 01 04.
Article in English | MEDLINE | ID: mdl-38177414

ABSTRACT

miR-374a-5p expression and localization in intracranial aneurysm (IA) tissues were detected, and its correlation with vascular smooth muscle cells (VSMCs) and macrophage markers was analyzed. Using platelet-derived growth factor-BB (PDGF-BB) induced VSMC model, elastase-induced IA rat model. Subsequently, miR-374a-5p was knocked down or overexpressed. We investigated the effects of miR-374a-5p on phenotypic conversion, and in vivo experiments were also carried out to verify the findings. The targeted relationship between miR-374a-5p and WNTA5 was analyzed. The effect of WNT5A inhibition on VSMC phenotypic transformation and THP-1-derived macrophage polarization was explored. Clinical studies have shown that miR-374a-5p was upregulated in IA patients. miR-374a-5p was negatively correlated with SM22α, α-SMA, CD206, and positively correlated with CD86. In vitro experiments showed that knocking down miR-374a-5p reversed the promotion of SM22α and α-SMA expression by PDGF-BB, while overexpression of miR-374a-5p had the opposite effect. In addition, knocking down miR-374a-5p also reversed the decrease in Calponin, TIMP3, TIMP4, and IL-10 levels caused by PDGF-BB, and further reduced the levels of MMP1, MMP3, MMP9, IL-1ß, IL-6, and TNF-α. These findings were further validated in vivo. In IA rats, there were notable increases in both systolic and diastolic blood pressure, along with an elevated M1/M2 ratio and the occurrence of vascular lesions. However, these symptoms were improved after knocking down miR-374a-5p. Furthermore, miR-374a-5p could target the WNT signals (WNT2B, WNT3, and WNT5A). miR-374a-5p regulated the VSMC phenotypic conversion and M1 macrophage polarization by targeting WNT5A, thereby impacting the progression of IA.


Subject(s)
Intracranial Aneurysm , MicroRNAs , Humans , Rats , Animals , MicroRNAs/genetics , MicroRNAs/metabolism , Muscle, Smooth, Vascular/metabolism , Becaplermin/metabolism , Intracranial Aneurysm/genetics , Intracranial Aneurysm/metabolism , Macrophages/metabolism , Myocytes, Smooth Muscle/metabolism , Phenotype , Cell Proliferation/physiology
4.
Phys Rev E ; 108(1-1): 014205, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37583163

ABSTRACT

Over the past decade, dynamic schemes have been proposed for the use of bistable systems in the design of logic devices. A bistable system in a noisy background can operate as a reliable logic gate in a moderate noise level, which is called a logical stochastic resonance (LSR). In this paper, we theoretically explore the emergence of LSR in general bistable systems and identify the dynamical mechanisms of LSR. The timescale relationship between the measured time and the mean first-pass time of two-state transitions is a key condition in determining whether the system is reliable. Furthermore, we demonstrate that the stability of the logic operation can be significantly improved by choosing the appropriate filtering method. Low-pass filtered noise-driven systems are more stable than Gaussian white noise. However, band-pass and high-pass filtered noise are harmful to the stability of the system due to the filtering of low-frequency components. Our theoretical and numerical simulation results offer perspectives for the development of logic devices.

5.
Sensors (Basel) ; 23(13)2023 Jul 07.
Article in English | MEDLINE | ID: mdl-37448068

ABSTRACT

Pipeline magnetic flux leakage inspection is widely used in the evaluation of material defect detection due to its advantages of having no coupling agent and easy implementation. The quantification of defect size is an important part of magnetic flux leakage testing. Defects of different geometrical dimensions produce signal waveforms with different characteristics after excitation. The key to achieving defect quantification is an accurate description of the relationship between the magnetic leakage signal and the size. In this paper, a calculation model for solving the defect leakage field based on the non-uniform magnetic charge distribution of magnetic dipoles is developed. Based on the traditional uniformly distributed magnetic charge model, the magnetic charge density distribution model is improved. Considering the variation of magnetic charge density with different depth positions, the triaxial signal characteristics of the defect are obtained by vector synthesis calculation. Simultaneous design of excitation pulling experiment. The leakage field distribution of rectangular defects with different geometries is analyzed. The experimental results show that the change in defect size will have an impact on the area of the defect leakage field distribution, and the larger the length and wider the width of the defect, the more sensitive the impact on the leakage field distribution. The solution model is consistent with the experimentally obtained leakage signal distribution law, and the model is a practical guide by which to improve the quality of defect evaluation.


Subject(s)
Magnetic Phenomena , Physical Phenomena
6.
Conserv Physiol ; 11(1): coad017, 2023.
Article in English | MEDLINE | ID: mdl-37101704

ABSTRACT

The environment noise may disturb animal behavior and echolocation via three potential mechanisms: acoustic masking, reduced attention and noise avoidance. Compared with the mechanisms of reduced attention and noise avoidance, acoustic masking is thought to occur only when the signal and background noise overlap spectrally and temporally. In this study, we investigated the effects of spectrally non-overlapping noise on echolocation pulses and electrophysiological responses of a constant frequency-frequency modulation (CF-FM) bat, Hipposideros pratti. We found that H. pratti called at higher intensities while keeping the CFs of their echolocation pulses consistent. Electrophysiological tests indicated that the noise could decrease auditory sensitivity and sharp intensity tuning, suggesting that spectrally non-overlapping noise imparts an acoustic masking effect. Because anthropogenic noises are usually concentrated at low frequencies and are spectrally non-overlapping with the bat's echolocation pulses, our results provide further evidence of negative consequences of anthropogenic noise. On this basis, we sound a warning against noise in the foraging habitats of echolocating bats.

7.
Article in English | MEDLINE | ID: mdl-37027265

ABSTRACT

Magnetic leakage detection technology plays an important role in the long-oil pipeline. Automatic segmentation of defecting images is crucial for the detection of magnetic flux leakage (MFL) works. At present, accurate segmentation for small defects has always been a difficult problem. In contrast to the state-of-the-art MFL detection methodologies based on convolution neural network (CNN), an optimization method is devised in our study by integrating mask region-based CNN (Mask R-CNN) and information entropy constraint (IEC). To be precise, the principal component analysis (PCA) is utilized to improve the feature learning and network segmentation ability of the convolution kernel. The similarity constraint rule of information entropy is proposed to be inserted into the convolution layer in the Mask R-CNN network. The Mask R-CNN optimizes the convolutional kernel with similar weights or higher similarity, meanwhile, the PCA network reduces the dimension of the feature image to reconstruct the original feature vector. As such, the feature extraction of MFL defects is optimized in the convolution check. The research results can be applied in the field of MFL detection.

8.
Hear Res ; 432: 108742, 2023 05.
Article in English | MEDLINE | ID: mdl-37004270

ABSTRACT

The Lombard effect, referring to an involuntary rise in vocal intensity, is a widespread vertebrate mechanism that aims to maintain signal efficiency in response to ambient noise. Previous studies showed that the Lombard effect could be sufficiently implemented at subcortical levels and operated by continuously monitoring background noise, requiring some subcortical auditory sensitive neurons to have continuous responses to background noise. However, such neurons have not been well characterized. The inferior colliculus (IC) is a major auditory integration center under the auditory cortex and provides projections to the putative vocal pattern generator in the brainstem. Thus, it is reasonable to speculate that the IC is a likely auditory nucleus candidate having background noise responding neurons (BNR neurons). In the present study, we isolated 183 sound-sensitive IC neurons in a constant frequency-frequency modulation bat, Hipposideros pratti, and found that around 19% of these IC neurons are BNR neurons when stimulated with 70 dB SPL background white noise. Their firing rates in response to noise increased with increasing noise intensity and could be suppressed by sound stimulation. Furthermore, compared to neurons with similar best frequencies, the BNR neurons had smaller Q10-dB values and lower noise-induced minimal threshold change, indicating that BNR neurons received fewer inhibitory inputs. These results suggested that the BNR neurons are ideal candidates for collecting information about background noise. We proposed that the BNR neurons synapsed with neurons in vocal-pattern-generating networks in the brainstem and initiated the Lombard effect by a feed-forward loop.


Subject(s)
Chiroptera , Echolocation , Inferior Colliculi , Animals , Inferior Colliculi/physiology , Chiroptera/physiology , Auditory Perception/physiology , Acoustic Stimulation , Echolocation/physiology , Neurons/physiology
9.
Sensors (Basel) ; 23(3)2023 Jan 19.
Article in English | MEDLINE | ID: mdl-36772185

ABSTRACT

Weak magnetic detection technology is an effective method to identify stress-induced damage to ferromagnetic materials, and it especially possesses great application potential in long-distance oil and gas pipeline weld crack detection. In the process of pipeline operation, due to internal pressure and external loads, local stress concentration may be generated, and partial stress concentration may lead to local cracks and expansion of the pipe. In order to improve the accuracy of magnetic signal analysis for ferromagnetic materials under internal pressure, the causes of magnetic signal generation at pipeline welds were analyzed from a microscopic perspective. The distributions of magnetic signals at pipeline welds, weld cracks, and base metal cracks under different internal pressures were numerically analyzed. The variation trends of magnetic signal characteristics, such as peak values of axial and radial components, gradient K, maximum gradient Kmax, and gradient energy factor S(K), were analyzed. In addition, experiments were carried out to verify the numerical data. It was revealed that with the elevation of internal pressure, the peak values of the axial and radial components, gradient K, maximum gradient Kmax, and gradient energy factor S(K) linearly increased. However, the magnitude and average change of S(K) were larger, which can more directly indicate variations of magnetic signals. The radial growth rate νy of S(K) was 3.24% higher than the axial growth rate νx, demonstrating that the radial component of the magnetic signal was more sensitive to variations of stress. This study provided a theoretical and experimental basis for detection of stress-induced damage to long-distance oil and gas pipelines.

10.
Sensors (Basel) ; 23(4)2023 Feb 07.
Article in English | MEDLINE | ID: mdl-36850454

ABSTRACT

In order to solve the problem of the quantification of detection signals in the magnetic flux leakage (MFL) of defective in-service oil and gas pipelines, a non-uniform magnetic charge model was established based on magnetic effects. The distribution patterns of magnetic charges under different stresses were analyzed. The influences of the elastic load and plastic deformation on the characteristic values of MFL signals were quantitatively assessed. The experimental results showed that the magnetic charge density was large at the edges of the defect and small at the center, and approximately decreased linearly with increasing stress. The eigenvalues of the axial and radial components of the MFL signals were compared, and it was found that the eigenvalues of the radial component exhibited a larger decline rate and were more sensitive to stress. With the increase in the plastic deformation, the characteristic values of the MFL signals initially decreased and then increased, and there was an inflection point. The location of the inflection point was associated with the magnetostriction coefficient. Compared with the uniform magnetic charge model, the accuracy of the axial and radial components of the MFL signals in the elastic stage of the improved magnetic charge model rose by 17% and 16%, respectively. The accuracy of the axial and radial components of the MFL signals were elevated by 9.15% and 9%, respectively, in the plastic stage.

11.
Clin Exp Hypertens ; 45(1): 2177667, 2023 Dec 31.
Article in English | MEDLINE | ID: mdl-36809885

ABSTRACT

BACKGROUND: Hypertensive intracerebral hemorrhage (HICH) is a life-threatening disease and lacks effective treatments. Previous studies have confirmed that metabolic profiles altered after ischemic stroke, but how brain metabolism changes after HICH was unclear. This study aimed to explore the metabolic profiles after HICH and the therapeutic effects of soyasaponin I on HICH. METHODS: HICH model was established first. Hematoxylin and eosin staining was used to estimate the pathological changes after HICH. Western blot and Evans blue extravasation assay were applied to determine the integrity of the blood-brain barrier (BBB). Enzyme-linked immunosorbent assay was used to detect the activation of the renin-angiotensin-aldosterone system (RAAS). Next, liquid chromatography-mass spectrometry-untargeted metabolomics was utilized to analyze the metabolic profiles of brain tissues after HICH. Finally, soyasaponin I was administered to HICH rats, and the severity of HICH and activation of the RAAS were further assessed. RESULTS: We successfully constructed HICH model. HICH significantly impaired BBB integrity and activated RAAS. HICH increased PE(14:0/24:1(15Z)), arachidonoyl serinol, PS(18:0/22:6(4Z, 7Z, 10Z, 13Z, 16Z, and 19Z)), PS(20:1(11Z)/20:5(5Z, 8Z, 11Z, 14Z, and 17Z)), glucose 1-phosphate, etc., in the brain, whereas decreased creatine, tripamide, D-N-(carboxyacetyl)alanine, N-acetylaspartate, N-acetylaspartylglutamic acid, and so on in the hemorrhagic hemisphere. Cerebral soyasaponin I was found to be downregulated after HICH and supplementation of soyasaponin I inactivated the RAAS and alleviated HICH. CONCLUSION: The metabolic profiles of the brains changed after HICH. Soyasaponin I alleviated HICH via inhibiting the RAAS and may serve as an effective drug for the treatment of HICH in the future.


Subject(s)
Intracranial Hemorrhage, Hypertensive , Oleanolic Acid , Saponins , Rats , Animals , Renin-Angiotensin System
12.
Plant Dis ; 107(7): 2133-2143, 2023 Jul.
Article in English | MEDLINE | ID: mdl-36541881

ABSTRACT

Winter wheat line Tianmin 668 was crossed with susceptible cultivar Jingshuang 16 to develop 216 recombinant inbred lines (RILs) for dissecting its adult-plant resistance (APR) and all-stage resistance (ASR) against powdery mildew. The RIL population was genotyped on a 16K genotyping by target sequencing single-nucleotide polymorphism array and phenotyped in six field trials and in the greenhouse. Three loci-QPmtj.caas-2BL, QPmtj.caas-2AS, and QPmtj.caas-5AL-conferring APR to powdery mildew were detected on chromosomes 2BL, 2AS, and 5AL, respectively, of Tianmin 668. The effect of resistance to powdery mildew for QPmtj.caas-2BL was greater than that of the other two loci. A Kompetitive allele-specific PCR marker specific for QPmtj.caas-2BL was developed and verified on 402 wheat cultivars or breeding lines. Results of virulence and avirulence patterns to 17 Blumeria graminis f. sp. tritici isolates, bulked segregant analysis-RNA-sequencing, and a genetic linkage mapping identified a resistance allele at locus Pm4 in Tianmin 668 based on the seedling phenotypes of the RIL population. The PCR-based DNA sequence alignment and cosegregation of the functional marker with the phenotypes of the RIL population demonstrated that Pm4d was responsible for the ASR to isolate Bgt1 in Tianmin 668. The dissection of genetic loci for APR and ASR may facilitate the application of Tianmin 668 in developing powdery mildew-resistant wheat cultivars.


Subject(s)
Erysiphe , Triticum , Triticum/genetics , Erysiphe/genetics , Seedlings/genetics , Genes, Plant
13.
Soc Sci Med ; 314: 115458, 2022 12.
Article in English | MEDLINE | ID: mdl-36279792

ABSTRACT

A key step to the establishment of a tiered healthcare system is equitable access to basic primary healthcare services for all. However, no quantitative research on the national status quo of primary healthcare accessibility in China exists. We filled this gap by estimating spatial accessibility to primary healthcare centers (PHCs) and mapping its inequality across the mainland China. Four national datasets during 2015-2018, including administrative boundaries, residential communities, points-of-interest (including PHCs), and road networks, were collected to calculate the distance to the nearest PHC for each community. Five other national datasets including census, elevation, land use, vegetation, and nightlight, were collected to model 100m × 100 m population grids, based on which geographical modeling was used to calculate PHC accessibility of each community. Inequalities in PHC accessibility across China were described with concentration indices. About 44% of communities across China representing approximately 30% of the overall population had no access to PHCs within their 6-km catchment areas; about 78% of communities across China representing approximately 68.4% of the overall population had no access to PHCs within their 1.5-km catchment areas. Some municipalities/provinces like Shanghai, Beijing, Tianjin, Jiangsu, Shandong, and Zhejiang generally had higher proximity to the nearest PHCs, while others like Tibet, Guizhou, and Guangxi had lower proximity to the nearest PHCs. However, assuming similar basic service capacity across all PHCs, Shanghai, Tianjin, and Chongqing showed the lowest PHC accessibility due to high population density. Variations in PHC accessibility existed, with more inequalities observed in the north and northeastern provinces and less inequalities in southwestern and south-central provinces. This study demonstrates primary healthcare accessibility and inequality at province and city levels, and identifies communities with lower proximity and accessibility to PHCs in China. It would serve as a starting point to facilitate precise healthcare planning and preparedness for health emergencies in China.


Subject(s)
Health Services Accessibility , Health Services , Humans , China/epidemiology , Catchment Area, Health , Primary Health Care
14.
Sensors (Basel) ; 22(17)2022 Aug 28.
Article in English | MEDLINE | ID: mdl-36080934

ABSTRACT

Accidents occur frequently in urban gas pipelines, and pipeline damage detection is an important means of ensuring pipeline safety. Aiming at the problem that the small diameter pipeline is difficult to detect, this paper proposes a detection method for the inner wall damage of a small-diameter pipeline based on the TE01 mode microwave and uses the TE01 mode to detect the inner wall damage of the pipeline by the terminal short-circuit reflection method. By analyzing the transition of microwave propagation mode at the defect, based on the Maxwell equation and the field distribution equation of the TE01 mode microwave in the pipe and the pipe wall current equation, the microwave reflection coefficient at the defect is established when the microwave distortion modes at the defect are TE and TM modes. A small-diameter pipeline simulation model is established, and the influence of the electric field, magnetic field, wall current distribution, and reflected wave reflection coefficient in the pipeline when inner wall defects of different widths are analyzed using the finite integral theory during microwave detection of the TE01 mode. An experimental platform for the microwave detection of small-diameter pipes was built to detect defects on the inner walls of pipes with different widths. The results show that the inner wall defect causes the electric field, magnetic field, current propagation period, and energy distribution of the TE01 mode microwave propagated in the pipe to be distorted, and the microwave reflection coefficient and return loss exhibit a significant frequency shift with the change in the defect width. The experimental and simulation results had a good consistency.

15.
Sensors (Basel) ; 22(18)2022 Sep 15.
Article in English | MEDLINE | ID: mdl-36146351

ABSTRACT

The balanced-field electromagnetic technique is an effective in-line inspection method for pipeline cracks. To address the problem that the interference signal generated by the tilt jitter of the sensor during the detection process affects the judgment of cracks, this paper proposes a method to differentiate the crack detection signal from the sensor jitter signal by using an amplitude-phase composite figure. The generation principle of the detection signal was analyzed by using the mutual inductance model, and the amplitude-phase composite figure was constructed by using the components of the detection signal after quadrature demodulation. The feasibility of using the phase as a signal discrimination feature was illustrated by finite element simulations, and the characteristics of the amplitude-phase composite figure were determined. The validity of the proposed method was verified experimentally. The results show that the crack detection signal and the signal generated by the sensor jitter are of the same frequency with similar waveforms and significantly different phases. The phase base value of the crack detection signal ranges from 35° to 55°, and the phase base value of the jitter signal is -4°. In terms of the characteristics of the amplitude-phase composite figure, the crack detection signal distribution is symmetrical about the origin in the first and third quadrants, and the axial crack is closer to the Y-axis than the circumferential crack; the jitter signal is distributed in the second and fourth quadrants and has a very small angle to the X-axis. In addition, the proposed method effectively weakens the observation of the phase noise region in the detection signal of the balanced-field electromagnetic technique.

16.
Sensors (Basel) ; 22(16)2022 Aug 13.
Article in English | MEDLINE | ID: mdl-36015826

ABSTRACT

The magnetic tomography method (MTM) is a non-contact external inspection method for detecting metal magnetic memory signals. It has great potential for application in long-distance oil pipeline and subsea pipeline inspection. However, the spatial distribution characteristics and propagation laws of magnetic signals are not yet clear, which makes the MTM passive detection. In this study, a three-dimensional mathematical model of the magnetic field distribution of the stress concentration zone outside the pipe was established based on the boundary conditions. For the two cases in which the stress concentration zone was located at the top and bottom of the inner wall of the pipe, the model was solved by finite element analysis. The variation law of the magnetic signal outside the pipe was analyzed, and experiments were designed to verify the model. The results show that the shape of the magnetic memory signal remained unchanged after passing through the pipe wall. As the magnetic permeability of the pipe medium is much larger than that of air, the magnetic memory signal is significantly attenuated after penetrating the pipe wall. As the detection height increases, the magnetic induction outside the tube decays exponentially. The results also prove that the magnetic tomography method can detect the stress concentration zone at any position of the pipeline, and the detection accuracy is higher when it is located at the top of the pipeline.


Subject(s)
Models, Theoretical , Tomography , Finite Element Analysis , Magnetic Phenomena , Physical Phenomena
17.
Sensors (Basel) ; 22(13)2022 Jun 27.
Article in English | MEDLINE | ID: mdl-35808343

ABSTRACT

With the aim of addressing the difficulty of detecting metal surface cracks and corrosion defects in complex environments, we propose a detection method for metal surface cracks and corrosion defects based on TE01-mode microwave. The microwave detection equations of cracks and corrosion defects were established by the Maxwell equations when the TE01 mode was excited by microwaves, and the relationship model between the defect size and the microwave characteristic quantity was established. A finite integral simulation model was established to analyze the influence of defects on the microwave electric field, magnetic field, and tube wall current in the rectangular waveguide, as well as the return loss at the defect; an experimental platform for the detection of metal surface cracks and corrosion defects was built. The absolute value of the return loss of the microwave reflected wave increased, and with the increase of the defect width, the microwave detection frequency at the defect decreased. The TE01-mode microwave has good detection ability for metal surface cracks and corrosion defects and can effectively detect cracks with a width of 0.3 mm.

18.
J Appl Microbiol ; 133(2): 972-986, 2022 Aug.
Article in English | MEDLINE | ID: mdl-35560738

ABSTRACT

AIMS: In recent years, the incidence rate of hypertensive intracerebral haemorrhage (HICH) has been increasing, accompanied by high mortality and morbidity, which has brought a heavy burden to the social economy. However, the pathogenesis of HICH is still unclear. This study intends to explore the mechanism of gut microbiota metabolism and inflammation in the process of HICH to provide a theoretical basis for the diagnosis and treatment of HICH. METHODS AND RESULTS: HE staining showed that the brain tissues of model group had obvious oedema injury, which indicated that the HICH model was successfully constructed. ELISA analysis showed that IL-1ß and TNF-α levels in blood and brain tissues were significantly increased, and IL-10 level was significantly decreased in blood. IHC analysis showed that microglia and macrophages were activated in the model group. 16S rRNA sequence showed that the diversity of gut microbiota in HICH patients decreased. Also, the microbiota belonging to Firmicutes, Proteobacteria and Verrucomicrobia changed significantly. LC-MS/MS analysis showed that the metabolic phenotype of HICH patients changed. Also, the 3,7-dimethyluric acid- and 7-methylxanthine-related metabolic pathways of caffeine metabolism pathways were downregulated in patients with HICH. Bacteroides was negatively correlated with the IL-1ß and TNF-α levels. Blautia was negatively correlated with the IL-1ß and TNF-α levels, and positively correlated with the IL-10 level. Akkermansia was negatively correlated with the 3,7-dimethyluric acid and 7-methylxanthine. CONCLUSION: Our study suggested that HICH was accompanied by the increased inflammation marker levels in peripheral blood and brain, decreased gut microbiota diversity, altered gut metabolic phenotype and downregulation of caffeine metabolism pathway. SIGNIFICANCE AND IMPACT OF THE STUDY: Our study reported that HICH accompanied by the increased inflammation, decreased gut microbiota diversity and altered gut metabolic phenotype. Due to the number of patients, this work was a pilot study.


Subject(s)
Gastrointestinal Microbiome , Intracranial Hemorrhage, Hypertensive , Caffeine/pharmacology , Chromatography, Liquid , Gastrointestinal Microbiome/genetics , Humans , Inflammation , Interleukin-10 , Pilot Projects , RNA, Ribosomal, 16S/genetics , Tandem Mass Spectrometry , Tumor Necrosis Factor-alpha
19.
Front Surg ; 9: 857877, 2022.
Article in English | MEDLINE | ID: mdl-35372491

ABSTRACT

Purpose: To explore the practical value of enteral nutrition care guided by evidence-based concepts in preventing enteral nutritional complications in critically ill neurosurgical patients. Methods: Three hundred critically ill patients from March 2020 to October 2021 from our neurosurgery department were included in the study. Patients were divided into a control group (March to December 2020, n = 150) and a study group (January to October 2021, n = 150) according to the order of their admission. The control group received conventional enteral nutrition care, and the study group received enteral nutrition care based on evidence-based concept guidance. The levels of serum nutritional indicators [hemoglobin (Hb), albumin (ALB), and total protein (TP)], feeding compliance rate, the incidence of complications (gastric retention, bloating, diarrhea, reflux, vomiting, aspiration, stress ulcers, etc.), and prognosis during the observation period were compared between the two groups. The scores of the questionnaire of knowledge, attitude, and practice on nutrition among neurosurgical nurses before and after the implementation of evidence-based care were compared among nursing staff in the study group. Results: At 1 and 2 weeks after enrollment, Hb, ALB, and TP levels were lower in both groups than before enrollment in the same group (P < 0.05). At 2 weeks after enrollment, Hb, ALB, and TP levels were higher in both groups than at 1 week after enrollment in the same group (P < 0.05). At 1 and 2 weeks after enrollment, Hb, ALB, and TP levels were higher in the study group than in the control group (P < 0.05). At 7 days after feeding, the feeding compliance rate was higher in the study group (94.67%) than in the control group (70.00%) (P < 0.05). The total complication rate was lower in the study group (8.00%) than in the control group (16.00%) (P < 0.05). The percentage of good prognosis was higher in the study group (34.00%) than in the control group (23.33%) (P < 0.05). After the implementation of evidence-based care, caregivers in the study group scored higher on nutrition knowledge, nutrition attitudes, and nutrition practices than those before the implementation (P < 0.05). Conclusion: The implementation of evidence-based nursing interventions in critically ill neurosurgical patients based on evidence-based concepts is of great clinical value in correcting their nutritional status, preventing enteral nutritional complications, improving prognosis, and enhancing the nutritional knowledge, attitudes, and practices of nursing staff.

20.
Sensors (Basel) ; 22(3)2022 Feb 02.
Article in English | MEDLINE | ID: mdl-35161873

ABSTRACT

Local stress concentrations pose a significant hazard to the safe operation of pipelines. However, the classical analytical model of the magnetic flux leakage (MFL) signal is still unable to effectively quantitatively analyze and accurately evaluate the local stress concentration zone of a pipeline. In this paper, based on the Jiles-Atherton model of the magnetomechanical effect, the mathematical relationship between stress and the magnetization of ferromagnetic material under hysteresis conditions is introduced, and an improved analytical model of the MFL signal based on the magnetomechanical model is established. The influence law of stress intensity on the MFL signal in the local stress concentration zone of the pipeline is calculated and analyzed, and the theoretical calculation results are verified through experiments. Simulation and experimental results show that, considering the hysteresis condition, the stress causes a change in the hysteresis loop of the ferromagnetic material, and the magnetization strength of the material decreases with increasing stress; the effect of stress on the magnetization strength of ferromagnetic materials is most obvious when the external magnetic field is approximately 5 KA/m. The MFL signal on the surface of the local stress concentration zone of the pipe changes abruptly, and the amount of change in the axial amplitude and radial peak-to-peak value of the leakage signal of the pipe tends to increase with the increase in the stress intensity of the local stress concentration zone. A comparison of the analysis with the classical analytical model of the MFL signal shows that the improved analytical model of the MFL signal is more suitable for the quantification study of the local stress concentration zone of the pipeline.


Subject(s)
Magnetic Phenomena , Magnets , Computer Simulation
SELECTION OF CITATIONS
SEARCH DETAIL
...