1.
RSC Adv
; 13(43): 30269-30272, 2023 Oct 11.
Article
in English
| MEDLINE
| ID: mdl-37881211
ABSTRACT
Reported here is the efficient macrocyclization facilitated by skeleton preorganization. A pyridylcarbazole macrocycle and a phenylpyridylcarbazole macrocycle was synthesized in yield up to 75%. Single-crystal structures and theoretic computation uncovered that the skeleton preorganization promoted the formation of cyclization-favorable conformation of noncyclic precursors via πâ¯π interactions. This result provided a new approach for the efficient syntheses of macrocycles.