Prevalence and risk factors for severe linezolid-associated thrombocytopenia in pediatric patients: An analysis of a public database.

Linezolid is widely used in various clinical settings. Studies have revealed that it may cause thrombocytopenia in adults. However, the correlation between the use of linezolid and thrombocytopenia in pediatric patients is still unclear. This study aimed to identify the impact of Linezolid on the occurrence of thrombocytopenia in children. A retrospective observational study was conducted using data on patients treated with linezolid from the Pediatric Intensive Care clinical database. Univariate and multiple logistic regression analyses were performed to identify the risk factors of linezolid-related severe thrombocytopenia. A total of 134 patients were included. The prevalence of severe thrombocytopenia was 8.96% (12/134). Univariate analysis indicated that the severe thrombocytopenia group showed significantly higher proportion of concomitant carbapenem (75% vs 44.3%; P < .05) and piperacillin/tazobactam (25% vs 6.6%; P < .05) than that of the non-severe thrombocytopenia group. Multivariate analysis also revealed that the occurrence of severe thrombocytopenia was significantly associated with concurrent use of carbapenem (odd ratio = 4.058; 95% confidence interval: 1.012-16.274; P = .048) and piperacillin/tazobactam (odd ratio = 5.335; 95% confidence interval: 1.117-25.478; P = .036). 75% of patients (9/12) developed severe thrombocytopenia within the first 7 days of linezolid use. The concomitant use of carbapenem and piperacillin/tazobactam was associated with an increased probability of severe thrombocytopenia in pediatric patients undergoing linezolid treatment. Further prospective clinical studies are required, and more detailed mechanisms of blood toxicity in pediatric patients must be investigated.

Strong Tracking PHD Filter Based on Variational Bayesian with Inaccurate Process and Measurement Noise Covariance.

Assuming that the measurement and process noise covariances are known, the probability hypothesis density (PHD) filter is effective in real-time multi-target tracking; however, noise covariance is often unknown and time-varying for an actual scene. To solve this problem, a strong tracking PHD filter based on Variational Bayes (VB) approximation is proposed in this paper. The measurement noise covariance is described in the linear system by the inverse Wishart (IW) distribution. Then, the fading factor in the strong tracking principle uses the optimal measurement noise covariance at the previous moment to control the state prediction covariance in real-time. The Gaussian IW (GIW) joint distribution adopts the VB approximation to jointly return the measurement noise covariance and the target state covariance. The simulation results show that, compared with the traditional Gaussian mixture PHD (GM-PHD) and the VB-adaptive PHD, the proposed algorithm has higher tracking accuracy and stronger robustness in a more reasonable calculation time.

Effects of reverse deployment of cone-shaped vena cava filter on improvements in hemodynamic performance in vena cava.

BACKGROUND: Cone-shaped vena cava filters (VCFs) are widely used to treat venous thromboembolism. However, in the long term, the problem of occlusion persists even after the filter is deployed. A previous study hypothesized that the reverse deployment of a cone-shaped VCFs may prevent filter blockage. METHODS: To explore this hypothesis, a comparative study of the traditional and reverse deployments of VCFs was conducted using a computational fluid dynamics approach. The distribution of wall shear stress (WSS) and shear stress-related parameters were calculated to evaluate the differences in hemodynamic effects between both conditions. In the animal experiment, we reversely deployed a filter in the vena cava of a goat and analyzed the blood clot distribution in the filter. RESULTS: The numerical simulation showed that the reverse deployment of a VCF resulted in a slightly higher shear rate on the thrombus, and no reductions in the oscillating shear index (OSI) and relative residence time (RRT) on the vessel wall. Comparing the traditional method with the reversely deployed cases, the shear rate values is 16.49 and 16.48 1/s, respectively; the minimal OSI values are 0.01 and 0.04, respectively; in the vicinity of the VCF, the RRT values are both approximately 5 1/Pa; and the WSS is approximately 0.3 Pa for both cases. Therefore, the reverse deployment of cone-shaped filters is not advantageous when compared with the traditional method in terms of local hemodynamics. However, it is effective in capturing thrombi in the short term, as demonstrated via animal experiments. The reversely deployed cone-shaped filter captured the thrombi at its center in the experiments. CONCLUSIONS: Thus, the reverse deployment of cone-shaped filters is not advantageous when compared with the traditional method in terms of local hemodynamics. Therefore, we would not suggest the reverse deployment of the cone-shaped filter in the vena cava to prevent a potentially fatal pulmonary embolism.

Effect of spraying on coal dust diffusion in a coal mine based on a numerical simulation.

Aimed at effectively controlling coal dust pollution in the mining face of a coal mine, this study first conducted a theoretical analysis and then combined a spraying experiment and a numerical simulation to perform an in-depth examination of the atomizing characteristics and dust suppression performance of a coal cutter external spraying device. Based on the experimental spraying results, the optimal nozzle was determined to be a pressure round-mouth nozzle with an X-shaped core. The characteristics of the spray fields from nozzles of different calibers (1.6, 2.0 and 2.4 mm) at different spraying pressures (2, 4, 6 and 8 MPa) were then analyzed. It was found that the droplet concentration in the spray field increased with increasing spraying pressure and nozzle caliber. The droplet diameter was mainly dependent on the spraying pressure and varied more slowly with increased spraying pressure. At a spraying pressure of 8 MPa, the spray field formed could achieve effective dust suppression; specifically, the droplet concentration in the spray field was mostly more than 15 g/m3, and the droplet size was mainly distributed in the range of 30-100 µm. When using a 2.4 mm caliber nozzle, the dust concentration measured around the coal cutter operator was reduced to 87.21 mg/m3 under a spraying pressure of 8 MPa, suggesting adequate dust suppression.

Rapid and facile method to prepare oxide precursor solution by using sonochemistry technology for WZTO thin film transistors.

In this paper, a rapid and facile method of preparing metal-oxide semiconductor precursor solution using sonochemistry technology is proposed. Compared with the traditional method (water bath above 60 °C for several hours), the efficiency of preparing solution is improved, because sonochemical reaction is found to accelerate the dissolution of solutes and the agitation of solution. The color comparison and thermal gravimetric and differential scanning calorimetry of solution confirme the formation of W-doped zinc tin oxide (WZTO) precursor solution with good performance. The effects of sonochemical reactions on the film structure, surface morphology, optical properties and chemical composition of WZTO thin films are analyzed by atomic force microscopy, X-ray diffraction, UV visible spectrum and X-ray photoelectron spectroscopy. The results show that the film has a smooth surface, an amorphous structure, a high transmittance and more M-O bonding. Hence, a rapid process of preparing WZTO solution (sonochemical treatment for 10 min) and fabricate TFT with high electron mobility (2.7 cm2 V-1 s-1) is established, while the corresponding mobility of the traditional method is 1.2 cm2 V-1 s-1. The results show that the sonochemical reaction can improve the efficiency of preparing solution by 1800% and it is a fast and efficient method for preparing precursor solutions.

Topical application of honey in the management of chemo/radiotherapy-induced oral mucositis: A systematic review and network meta-analysis.

BACKGROUND: Mucositis is an inflammatory response of mucosal epithelial cells to the cytotoxic effects of chemotherapy and radiation therapy. To assess the comparative efficacy of honey for patients with cancer undergoing chemo/radiotherapy-induced oral mucositis through a systematic review and network meta-analysis. METHODS: A network meta-analysis was used to identify evidence from relevant randomized controlled trials (RCTs). We searched PubMed, Embase, and the Cochrane Library for publications up to November 2017. The prespecified primary efficacy outcome was the treatment effect of moderate-severe oral mucositis with honey. We performed subgroup analyses and meta-regressions according to the age group, cancer type, mucositis cause, honey type, control arm and type of assessment scale. Moreover, secondary efficacy outcomes were treatment completed, onset time of mucositis, swallowing diary, fungal colonization, bacterial colonisation and analgesic use. And, we did standardize meta-analyses using the random-effects model, later completing the random-effects network meta-analyses by different treatment/control arms. RESULTS: A total of 17 RCTs were eligible (22 analyses), involving 1265 patients and 13 arms. Honey treatment arm significantly increased the therapeutic effect of chemo/radiotherapy-induced moderate-severe oral mucositis (0.25, 0.14-0.46); significant efficacy was observed in a large proportion of subgroups. The meta-regression may have identified the causes of heterogeneity as the honey type (P = 0.038). Therefore, we need to perform further comparisons of difference in honey types and controls by network meta-analysis, and the results from network meta-analysis revealed that pure natural honey was superior in therapeutic effect (0.05, 0.01-0.46). For secondary outcomes, significant effect was found in decreasing onset time of mucositis (0.41, 0.08-0.73), while no increase in adverse effects was observed. The study is registered with PROSPERO (CRD42017070873). CONCLUSIONS: The adjuvant treatment honey is effective and safe for patients with cancer undergoing chemo/radiotherapy-induced oral mucositis, especially applied pure natural local honey can be invoked as a first-line adjuvant therapy agent.

Development of a novel wind-assisted centralized spraying dedusting device for dust suppression in a fully mechanized mining face.

Aiming at addressing serious pollution in the No. 30106 fully mechanized coal mining face of Shiquan Coal Mine during coal cutting process, the spraying device between hydraulic supports was improved through the combination of experimental analysis, numerical simulation, and field measurement, and a novel wind-assisted centralized spraying dedusting device was developed. The newly developed device could make the formed spraying field more concentrated on the dust-producing source around the coal shearer's drum, and thus significantly enhanced the spraying performance. According to numerical simulation results, the spraying performance reached the optimum at a hydraulic pressure of 8 MPa for the spraying device and an air pressure of 1 MPa for the pneumatic motor; under these optimal conditions, the droplet concentration in the spraying field around the coal cutter drum was as high as 24.85 g/m3, and the formed high-concentration spraying field could basically cover the whole section in the spraying field from coal wall to the support pillar. Field measured results revealed that, at a hydraulic pressure of 8 MPa and an air pressure of 1 MPa, the dust suppression rate around coal cutter driver reached up to 87.96%, suggesting that the developed wind-assisted centralized spraying dedusting device had remarkable dust suppression performance and could effectively improve the operating environment in the fully mechanized mining face. Graphical Abstract In this paper, we have designed a novel wind-assisted centralized spraying dedusting device and studied the optimal spray parameters. Firstly, the nozzles were selected according to the multi-factor experimental platform for measuring the spraying field's atomization characteristics. Secondly, we had a numerical simulation of the fully mechanized mining face. And the third, we tested the effect of dust removal.

Ammonia exposure alters the expression of immune-related and antioxidant enzymes-related genes and the gut microbial community of crucian carp (Carassius auratus).

Chronic exposure of ammonia in fish can affect the activities of antioxidant enzymes but few studies investigate the influence of ammonia exposure on the expression of immune-related and antioxidant enzymes-related genes. Also, there is no study demonstrates the effect of ammonia exposure on gut microbial community of fish. In this study, crucian carp (Carassius auratus) were exposed to the ammonia concentrations, 0 (control), 10 mg L-1 (low) or 50 mg L-1 (high) for consecutive 30 days at 25 ± 1 °C temperature, respectively, and after that, the fish from all exposure groups were maintained in control conditions for another 15 days. The results showed that low concentration ammonia increased the expression of immune-related genes and antioxidant enzymes-related genes, but high concentration ammonia inhibited the expression of immune-related genes and antioxidant enzymes-related genes. After a 15-day treatment without ammonia, the expression of antioxidant enzymes-related genes and immune-related genes showed no significant changes compared with control. The results of high-throughput sequencing showed that gut microbial communities were significantly differentiated following ammonia exposure. The abundance of Bacteroides and Cetobacterium (two kinds of potential probiotics) increased while fish exposed to 10 mg L-1 ammonia. The Flavobacterium (a potential fish pathogen) showed increasing trends when the exposure dose reached 50 mg L-1, while the Bacteroides and Cetobacterium showed almost no abundance. The results also revealed that ammonia exposure concentration or time can alter the intestinal microbial community. In conclusion, ammonia exposure could induce the immune response in crucian carp, and alter the gut microbial community. The results may help us understand the correlations of gut microbial community shift and ammonia exposure and extend our knowledge to comprehend the effects of environmental factors on intestinal microbial community.

Electrical Impedance Tomography-guided PEEP Titration in Patients Undergoing Laparoscopic Abdominal Surgery.

The aim of the study is to utilize electrical impedance tomography (EIT) to guide positive end-expiratory pressure (PEEP) and to optimize oxygenation in patients undergoing laparoscopic abdominal surgery.Fifty patients were randomly assigned to the control (C) group and the EIT (E) group (n = 25 each). We set the fraction of inspired oxygen (FiO2) at 0.30. The PEEP was titrated and increased in a 2-cm H2O stepwise manner, from 6 to 14 cm H2O. Hemodynamic variables, respiratory mechanics, EIT images, analysis of blood gas, and regional cerebral oxygen saturation were recorded. The postoperative pulmonary complications within the first 5 days were also observed.We chose 10 cm H2O and 8 cm H2O as the "ideal" PEEP for the C and the E groups, respectively. EIT-guided PEEP titration led to a more dorsal shift of ventilation. The PaO2/FiO2 ratio in the E group was superior to that in the C group in the pneumoperitoneum period, though the difference was not significant (330 ±â€Š10 vs 305.56 ±â€Š4 mm Hg; P = 0.09). The C group patients experienced 8.7% postoperative pulmonary complications versus 5.3% among the E group patients (relative risk 1.27, 95% confidence interval 0.31-5.3, P = 0.75).Electrical impedance tomography represents a new promising technique that could enable anesthesiologists to assess regional ventilation of the lungs and optimize global oxygenation for patients undergoing laparoscopic abdominal surgery.