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1.
Proc Natl Acad Sci U S A ; 121(23): e2403544121, 2024 Jun 04.
Article in English | MEDLINE | ID: mdl-38805289

ABSTRACT

Peracetic acid (PAA) is emerging as a versatile agent for generating long-lived and selectively oxidative organic radicals (R-O•). Currently, the conventional transition metal-based activation strategies still suffer from metal ion leaching, undesirable by-products formation, and uncontrolled reactive species production. To address these challenges, we present a method employing BiOI with a unique electron structure as a PAA activator, thereby predominantly generating CH3C(O)O• radicals. The specificity of CH3C(O)O• generation ensured the superior performance of the BiOI/PAA system across a wide pH range (2.0 to 11.0), even in the presence of complex interfering substances such as humic acids, chloride ions, bicarbonate ions, and real-world water matrices. Unlike conventional catalytic oxidative methods, the BiOI/PAA system degrades sulfonamides without producing any toxic by-products. Our findings demonstrate the advantages of CH3C(O)O• in water decontamination and pave the way for the development of eco-friendly water decontaminations based on organic peroxides.

2.
PNAS Nexus ; 3(2): pgae040, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38328784

ABSTRACT

Aromatic amines (AAs), ubiquitous in industrial applications, pose significant environmental hazards due to their resistance to conventional wastewater treatments. Peracetic acid (PAA)-based advanced oxidation processes (AOPs) have been proposed as effective strategies for addressing persistent AA contaminants. While the organic radicals generated in these systems are believed to be selective and highly oxidative, acetate residue complicates the evaluation of AA removal efficiency. In this work, we explored transformation pathways of AAs in a representative Co(II)-catalyzed PAA system, revealing five side reactions (i.e. nitrosation, nitration, coupling, dimerization, and acetylation) that yield 17 predominantly stable and toxic by-products. The dominant reactive species was demonstrated as Co-OOC(O)CH3, which hardly facilitated ring-opening reactions. Our findings highlight the potential risks associated with PAA-based AOPs for AA degradation and provide insights into selecting suitable catalytic systems aimed at efficient and by-product-free degradation of pollutants containing aromatic -NH2.

3.
Proc Natl Acad Sci U S A ; 120(30): e2305706120, 2023 Jul 25.
Article in English | MEDLINE | ID: mdl-37459516

ABSTRACT

Singlet oxygen (1O2) plays a pivotal role in numerous catalytic oxidation processes utilized in water purification and chemical synthesis. The spin-trapping method based on electron paramagnetic resonance (EPR) analysis is commonly employed for 1O2 detection. However, it is often limited to time-independent acquisition. Recent studies have raised questions about the reliability of the 1O2 trapper, 2,2,6,6-tetramethylpiperidine (TEMP), in various systems. In this study, we introduce a comprehensive, kinetic examination to monitor the spin-trapping process in EPR analysis. The EPR intensity of the trapping product was used as a quantitative measurement to evaluate the concentration of 1O2 in aqueous systems. This in situ kinetic study was successfully applied to a classical photocatalytic system with exceptional accuracy. Furthermore, we demonstrated the feasibility of our approach in more intricate 1O2-driven catalytic oxidation processes for water decontamination and elucidated the molecular mechanism of direct TEMP oxidation. This method can avoid the false-positive results associated with the conventional 2D 1O2 detection techniques, and provide insights into the reaction mechanisms in 1O2-dominated catalytic oxidation processes. This work underscores the necessity of kinetic studies for spin-trapping EPR analysis, presenting an avenue for a comprehensive exploration of the mechanisms governing catalytic oxidation processes.

4.
J Clin Lab Anal ; 36(7): e24386, 2022 Jul.
Article in English | MEDLINE | ID: mdl-35582743

ABSTRACT

BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) is a severe complication among patients receiving intravascular contrast media. The purpose of this study was to investigate the preventive effects of pretreatment of atorvastatin at intensive doses on CI-AKI after computed tomography (CT) perfusion. METHODS: The levels of serum creatinine (SCR), blood urea nitrogen (BUN), Cystatin C (CysC), estimated glomerular filtration rate (eGFR), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) in patients were compared between the observation group receiving 40 mg/kg atorvastatin and the control group receiving 20 mg/kg atorvastatin before and 72 h after CT examination. In addition, the incidence of CI-AKI was recorded. RESULTS: Compared with the control group, the incidence of renal injury in the observation group was significantly reduced, from 8% to 2% (χ2  = 6.62, p = 0.010). In addition, there was no notable difference in the levels of Scr, BUN, CysC, hs-CRP, and IL-6 before CT examination between two groups (p > 0.05). The levels of SCR, BUN, CysC, hs-CRP, and IL-6 were increased, while the levels of eGFR were decreased in the control group at 72 h after CT examination (p < 0.05). At 72 h after CT enhancement, the levels of BUN, CysC, and hs-CRP were prominently increased in the observation group (p < 0.05), while SCR, eGFR, and IL-6 did not change (p > 0.05). Compared with the control group, the levels of SCR, BUN, CysC, eGFR, hs-CRP, and IL-6 in the observation group were significantly decreased at 72 h after CT examination (p < 0.05). CONCLUSION: Intensive dose of atorvastatin pretreatment can prevent CI-AKI undergoing CT perfusion through lowering inflammation as well as renal function indexes SCR, CysC, BUN, and eGFR.


Subject(s)
Acute Kidney Injury , Atorvastatin , Contrast Media , Acute Kidney Injury/chemically induced , Acute Kidney Injury/prevention & control , Atorvastatin/therapeutic use , Biomarkers , C-Reactive Protein , Contrast Media/adverse effects , Creatinine , Glomerular Filtration Rate , Humans , Interleukin-6 , Perfusion , Tomography, X-Ray Computed
5.
Zhonghua Xin Xue Guan Bing Za Zhi ; 39(9): 797-801, 2011 Sep.
Article in Chinese | MEDLINE | ID: mdl-22321225

ABSTRACT

OBJECTIVE: To elucidate the roles of monocyte chemotactic factors (MCP-1, RANTES and Fractalkine) on the vulnerability of atherosclerotic plaques in patients with stable (SAP) and unstable angina pectoris (UAP). METHODS: Patients with SAP (n = 50) and UAP (n = 50) underwent coronary angiography (CAG) and intravenous ultrasound (IVUS) were included in the study. Monocyte chemotaxis was assayed by the transwell chamber. Concentrations of hs-CRP, MCP-1, RANTES and Fractalkine were measured by Enzyme-linked-immunosorbent assay (ELISA). mRNA expression of MCP-1, RANTES and Fractalkine in the monocytes was detected by RT-PCR. RESULTS: IVUS evidenced soft lipid plaques in 48% UAP patients and in 16% SAP patients (P < 0.05). SAP patients had mainly fibrous and mixed plaques. Plaque burden and vascular remodeling index were significantly higher in UAP patients than in SAP patients (P < 0.01). The averaged number of migrated monocytes in the UAP patients were higher than that in patients with SAP (P < 0.01). Concentration of hs-CRP, MCP-1, RANTES and Fractalkine were significantly higher in UAP patients than those of SAP patients (P < 0.05 or P < 0.01). mRNA expression of MCP-1, RANTES and Fractalkine in patients with UAP was significantly higher than those of SAP patients (P < 0.05). CONCLUSION: Upregulated monocyte chemotactic factors (MCP-1, RANTES and Fractalkine) might promote coronary plaque vulnerability in UAP patients.


Subject(s)
Angina Pectoris/metabolism , Angina, Unstable/metabolism , Chemokine CCL2/metabolism , Chemokine CCL5/metabolism , Chemokine CX3CL1/metabolism , Plaque, Atherosclerotic/pathology , Angina Pectoris/pathology , Angina, Unstable/pathology , Coronary Angiography , Female , Humans , Male , Middle Aged , RNA, Messenger/genetics
6.
Zhonghua Wai Ke Za Zhi ; 45(4): 220-2, 2007 Feb 15.
Article in Chinese | MEDLINE | ID: mdl-17502011

ABSTRACT

OBJECTIVE: To discuss the avail of balloon and stent-assisted Guglielmi detachable coil (GDC) placement in treatment of wide-necked cerebral aneurysm. METHODS: Eighty-seven patients with 92 wide-necked aneurysms undergone endovascular procedures using the balloon and stent-assisted remodeling technique. Respectively, appropriate Neuroform stents delivered with a 5 mm landing zone on either side of the aneurysm neck, the microcatheter entered through the interstice, aneurysms were embolized at one or several times. Two catheters were used in balloon-remodeling technique, balloon were inflated across the neck of the aneurysms after the microcatheter entering the aneurysms, then the GDC were used to embolize the aneurysms. RESULTS: Thirty-one aneurysms were completely occluded, 3 subtotally (> 90%) and 1 incompletely (70% - 90%) occluded using stent-assisted technique, all carry arteries were unblocked, 3 patients with mild neurological dysfunction and no mortality. Fifty aneurysms were completely occluded and 4 incompletely occluded using balloon-assisted technique, 1 patients with mild neurological dysfunction and no mortality. Two aneurysms were completely occluded and 1 incompletely occluded using stent-assisted and balloon-assisted technique. The mean period of follow-up was 5.8 months. Rates of recanalization were 16.7% for stent-remodeling group and 12.5% for balloon-remodeling group. CONCLUSIONS: The stent and balloon-assisted remodeling technique are safe and effective in treating wide-necked aneurysms. Balloon-remodeling technique has more security comparing with stents.


Subject(s)
Angioplasty, Balloon , Embolization, Therapeutic/methods , Intracranial Aneurysm/therapy , Stents , Female , Follow-Up Studies , Humans , Male , Middle Aged , Retrospective Studies , Treatment Outcome
7.
Zhonghua Yi Xue Za Zhi ; 87(8): 559-61, 2007 Feb 27.
Article in Chinese | MEDLINE | ID: mdl-17459211

ABSTRACT

OBJECTIVE: To compare the appliance values off 3-dimension computed tomography (CTA) and digital subtraction angiography (DSA) in diagnosis of intracranial aneurysm (ICA). METHODS: Eighty-six with subarachnoid hemorrhage underwent 2-D DSA, and 3-DCTA and 3-D DSA, both including maximum intensity projection (MIP) and multiple planner reconstruction (MPR), volume rending (VR). The accuracy, misdiagnosis rate, and missed diagnosis rate of these 3 techniques were compared. No significant complication was found. RESULTS: Ninety-four aneurysms were found in 74 patients. CTA examination obtained satisfactory MPR, MIP, and VR images in all patients. There was no significant difference in accuracy between 3D-DSA and 3D-CTA. In display of the aneurysm 3D-CTA was not significantly different from 2D-DSA in most cases. In display of the neck of aneurysm 3D-CTA was not significantly different from 3D-DSA, and these 3 techniques were both superior to 2D-DSA. CONCLUSION: 3D-CTA is the first choice examination technique for patients with subarachnoid hemorrhage. The information obtained by 2D-DSA, 3D-DSA, and 3D-CTA should be considered comprehensively.


Subject(s)
Angiography, Digital Subtraction/methods , Cerebral Angiography/methods , Imaging, Three-Dimensional , Intracranial Aneurysm/diagnosis , Subarachnoid Hemorrhage/diagnostic imaging , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Reproducibility of Results , Sensitivity and Specificity , Tomography, Spiral Computed
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