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1.
Sensors (Basel) ; 23(24)2023 Dec 16.
Article in English | MEDLINE | ID: mdl-38139720

ABSTRACT

An Mw 6.8 earthquake occurred in Luding County, Ganzi Tibetan Autonomous Prefecture, Sichuan Province, on 5 September 2022. This seismic event triggered numerous coseismic geohazards in the seismic zone. In this study, the ascending- and descending-track synthetic aperture radar (SAR) images observed by the Sentinel-1A satellite are utilized to extract the coseismic surface deformation of the Luding earthquake. Subsequently, a faulting model is estimated based on the elastic dislocation theory, under the constraint of the InSAR observation. Additionally, the POT technique was employed to detect coseismic geohazards. High-spatial-resolution optical remote sensing images served to validate the reliability of the detection results. The coseismic interferometric synthetic aperture radar (InSAR) deformation field indicated a maximum deformation of ~190 mm and ~140 mm along the ascending and descending tracks, respectively. The estimated best-fitting faulting model suggests that the optimal seismogenic fault strike and dip angles are 169.3° and 70°, respectively. The fault slip predominantly exhibits left-lateral strike-slip characteristics and is concentrated at depths of 3-12 km. The estimated maximum fault slip was 2.67 m, occurring at a depth of 7 km. The pixel offset tracking (POT) result derived from the pre- and post-earthquake SAR images found a total of 245 medium- to large-scale coseismic geohazards, with a verification rate from optical images exceeding 64%. The distribution of these geohazards is notably dense within the significant fault rupture segment. Geohazards on the fault hanging wall are densely packed, whereas landslides along the Dadu River's fault footwall are also notably frequent.

2.
J Am Chem Soc ; 2023 Nov 01.
Article in English | MEDLINE | ID: mdl-37909780

ABSTRACT

Electrochemical Li-alloying reactions with Li-rich alloy phases render a much higher theoretical capacity that is critical for high-energy batteries, and the accompanying phase transition determines the alloying/dealloying reversibility and cycling stability. However, the influence of phase-transition characteristics upon the thermodynamic properties and diffusion kinetic mechanisms among the two categories of alloys, solid-solutions and intermetallic compounds, remains incomplete. Here we investigated three representative Li-alloys: Li-Ag alloy of extended solid-solution regions; Li-Zn alloy of an intermetallic compound with a solid-solution phase of a very narrow window in Li atom concentration; and Li-Al alloy of an intermetallic compound. Solid-solution phases undertake a much lower phase-transition energy barrier than the intermetallic compounds, leading to a considerably higher Li-alloying/dealloying reversibility and cycling stability, which is due to the subtle structural change and chemical potential gradient built up inside of the solid-solution phases. These two effects enable the Li atoms to enter the bulk of the Li-Ag alloy to form a homogeneous alloy phase. The pouch cell of the Li-rich Li20Ag alloy pairs with a LiNi0.8Co0.1Mn0.1O2 cathode under an areal capacity of 3.5 mAh cm-2 can retain 87% of its initial capacity after 250 cycles with an enhanced Coulombic efficiency of 99.8 ± 0.1%. While Li-alloying reactions and the alloy phase transitions have always been tightly linked in past studies, our findings provide important guidelines for the intelligent design of components for secondary metal batteries.

3.
Genes (Basel) ; 14(11)2023 Nov 20.
Article in English | MEDLINE | ID: mdl-38003049

ABSTRACT

Sweet potato (Ipomoea batatas (L.) Lam.) is one of the most important food, feed, industrial raw materials, and new energy crops, and is widely cultivated around the world. China is the largest sweet potato producer in the world, and the sweet potato industry plays an important role in China's agriculture. During the growth of sweet potato, it is often affected by biotic stresses, such as fungi, nematodes, insects, viruses, and bacteria. These stressors are widespread worldwide and have severely restricted the production of sweet potato. In recent years, with the rapid development and maturity of biotechnology, an increasing number of stress-related genes have been introduced into sweet potato, which improves its quality and resistance of sweet potato. This paper summarizes the discovery of biological stress-related genes in sweet potato and the related mechanisms of stress resistance from the perspectives of genomics analysis, transcriptomics analysis, genetic engineering, and physiological and biochemical indicators. The mechanisms of stress resistance provide a reference for analyzing the molecular breeding of disease resistance mechanisms and biotic stress resistance in sweet potato.


Subject(s)
Ipomoea batatas , Ipomoea batatas/genetics , Stress, Physiological/genetics , Biotechnology , Gene Expression Profiling , Genomics
4.
Front Microbiol ; 14: 1250330, 2023.
Article in English | MEDLINE | ID: mdl-37799601

ABSTRACT

Acidithiobacillus caldus plays an important role in bioleaching of low-grade metal ore. It can promote the release of heavy metals in mining-associated habitats and survive in high concentrations of heavy metals. Functions of glutathione reductase (GR) in cell defense against reactive oxygen species caused by heavy metals have been elucidated in some eukaryotic cells and bacteria; however, no information is available in A. caldus. In this research, the methods of bioinformatics, gene expression, GR activity assays were used to detect and characterize the glutathione reductase gene from the A. caldus MTH-04 strain. Then, A. caldus gr knockout mutant and gr overexpression strain were constructed, and the heavy metal tolerant properties and transcriptional levels of ROS related genes of them were compared to study the function of GR. The results showed that, a putative gr gene F0726_RS04210 was detected in the genome of A. caldus MTH-04. The purified recombinant protein of F0726_RS04210 showed remarkable GR activity at optimal pH 7.0 and 30°C using in vitro assay. The evolutionary relationship of GR from A. caldus MTH-04 was close to that from Escherichia coli K12. Gene knockout or overexpression of gr in A. caldus did not affect the growth rate on S0 medium, suggesting that GR did not play a key role in the activation of sulfur. Deletion of gr resulted in increased sensitivity to heavy metals (Cu2+ and Zn2+) in A. caldus, and the gr overexpression strain showed enhanced tolerance to heavy metals. Furthermore, transcription analysis also revealed strong correlations between GR and the antioxidant pathway. The above results suggest that GR can play an important role in heavy metal tolerance in A. caldus.

5.
PeerJ ; 11: e15720, 2023.
Article in English | MEDLINE | ID: mdl-37551350

ABSTRACT

Human activities are increasing the input of atmospheric particulate pollutants to forests. The components of particulate pollutants include inorganic anions, base cations and hydrocarbons. Continuous input of particulate pollutants may affect soil functioning in forests, but their effects may be modified by soil fauna. However, studies investigating how soil fauna affects the effects of particulate pollutants on soil functioning are lacking. Here, we investigated how earthworms and the particulate components interact in affecting soil enzymatic functions in a deciduous (Quercus variabilis) and a coniferous (Pinus massoniana) forest in southeast China. We manipulated the addition of nitrogen (N, ammonium nitrate), sodium (Na, sodium chloride) and polycyclic aromatic hydrocarbons (PAHs, five mixed PAHs) in field mesocosms with and without Eisenia fetida, an earthworm species colonizing forests in eastern China. After one year, N and Na addition increased, whereas PAHs decreased soil enzymatic functions, based on average Z scores of extracellular enzyme activities. Earthworms generally stabilized soil enzymatic functions via neutralizing the effects of N, Na and PAHs addition in the deciduous but not in the coniferous forest. Specifically, earthworms neutralized the effects of N and Na addition on soil pH and the effects of the addition of PAHs on soil microbial biomass. Further, both particulate components and earthworms changed the correlations among soil enzymatic and other ecosystem functions in the deciduous forest, but the effects depended on the type of particulate components. Generally, the effects of particulate components and earthworms on soil enzymatic functions were weaker in the coniferous than the deciduous forest. Overall, the results indicate that earthworms stabilize soil enzymatic functions in the deciduous but not the coniferous forest irrespective of the type of particulate components. This suggests that earthworms may neutralize the influence of atmospheric particulate pollutants on ecosystem functions, but the neutralization may be restricted to deciduous forests.


Subject(s)
Environmental Pollutants , Oligochaeta , Polycyclic Aromatic Hydrocarbons , Animals , Humans , Ecosystem , Forests , Soil
6.
Entropy (Basel) ; 25(7)2023 Jul 17.
Article in English | MEDLINE | ID: mdl-37510021

ABSTRACT

In this paper, we investigate an uncertainty diagram and Kirkwood-Dirac (KD) nonclassicality based on discrete Fourier transform (DFT) in a d-dimensional system. We first consider the uncertainty diagram of the DFT matrix, which is a transition matrix from basis A to basis B. Here, the bases A, B are not necessarily completely incompatible. We show that for the uncertainty diagram of the DFT matrix, there is no "hole" in the region of the (nA,nB) plane above and on the line nA+nB=d+1. Then, we present where the holes are in the region strictly below the line and above the hyperbola nAnB=d. Finally, we provide an alternative proof of the conjecture about KD nonclassicality based on DFT.

7.
Chemosphere ; 329: 138504, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37011822

ABSTRACT

Biodegradable plastic is considered one of the most promising alternatives to agricultural mulch. However, the impact of biodegradable microplastics on agricultural ecosystems is still lacking. We conducted a controlled experiment with polylactic acid microplastics (PLA MPs) to examine the effects of biodegradable plastic on soil properties, corn growth, the microbial community and hotspots of enzyme activity. The results showed that PLA MPs in soil significantly reduced the soil pH value but increased the soil C:N ratio. High levels of PLA MPs significantly reduced the biomass of plant shoots and roots as well as chlorophyll, leaf C and N and root N contents. PLA MPs increased bacterial abundance but decreased the abundance of dominant fungal taxa. As the level of PLA MPs increased, the soil bacterial community structure became more complex, while the fungal community became more singular. The results of the in situ zymogram showed that low levels of PLA MPs increased the hotspots of enzyme activity. The effect of PLA MPs on enzyme activity hotspots was regulated by a combination of soil properties and microbial diversity. Generally, the addition of PLA MPs at high concentrations will have a negative impact on soil characteristics, soil microbials and plant growth in a short period of time. Therefore, we should be aware of the potential risks of biodegradable plastic to agricultural ecosystems.


Subject(s)
Biodegradable Plastics , Microbiota , Microplastics , Plastics/toxicity , Polyesters , Soil , Soil Microbiology
8.
Ann N Y Acad Sci ; 1520(1): 127-139, 2023 02.
Article in English | MEDLINE | ID: mdl-36478220

ABSTRACT

Building robust letter-to-sound correspondences is a prerequisite for developing reading capacity. However, the neural mechanisms underlying the development of audiovisual integration for reading are largely unknown. This study used functional magnetic resonance imaging in a lexical decision task to investigate functional brain networks that support audiovisual integration during reading in developing child readers (10-12 years old) and skilled adult readers (20-28 years old). The results revealed enhanced connectivity in a prefrontal-superior temporal network (including the right medial frontal gyrus, right superior frontal gyrus, and left superior temporal gyrus) in adults relative to children, reflecting the development of attentional modulation of audiovisual integration involved in reading processing. Furthermore, the connectivity strength of this brain network was correlated with reading accuracy. Collectively, this study, for the first time, elucidates the differences in brain networks of audiovisual integration for reading between children and adults, promoting the understanding of the neurodevelopment of multisensory integration in high-level human cognition.


Subject(s)
Brain Mapping , Brain , Humans , Adult , Child , Young Adult , Temporal Lobe , Attention , Prefrontal Cortex , Magnetic Resonance Imaging
9.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-972227

ABSTRACT

Objective @#To investigate the clinical efficacy and application value of an improved 3D-printed guide plate for the treatment of primary trigeminal neuralgia (PTN) by percutaneous microballoon compression (PMC). @*Methods @# This prospective study included 42 patients with primary trigeminal neuralgia treated at the Department of Stomatology, Xuzhou Central Hospital, from September 2019 to January 2022. The group was divided by the random number table method into the experimental group (adopting 3D printing technology to make guide plates to guide the puncture, 22 cases) and the control group (adopting the traditional Hartel anterior approach to position the puncture, 20 cases). The intraoperative success rate of the first puncture, puncture time, operative time, radiation exposure of patients and postoperative complications were compared between the two groups. Postoperative Barrow Neurological Institute Scale (BNI) scores, facial numbness, diminished corneal reflexes and chewing weakness were recorded. The t-test, rank-sum test and chi-square test were used for statistical analysis, with P<0.05 indicating a statistically significant difference. @*Results @#The experimental group was significantly better than the control group in terms of the success rate of the first puncture (χ2 = 21.51, P<0.001), puncture time (Z = -5.51, P<0.001), operative time (t = 9.37, P<0.001), and the number of C-arm scans (Z = -4.59, P<0.001). Postoperative BNI scores of the experimental group included 21 cases of grade Ⅰ (91.5%) and 1 case of grade Ⅱ, while the control group included 17 cases of grade Ⅰ (85.0%), 2 cases of grade Ⅱ (10.0%) and 1 case of grade Ⅲ (5.0%), with no statistical significance (P>0.05). In the experimental group, 16 patients had postoperative masseter weakness, 1 had keratitis and 10 had perilabial herpes, while in the control group, 18 patients had postoperative masseter weakness, 2 had keratitis, 11 had perilabial herpes and 1 had monocular blindness. There was no significant difference in postoperative complications between the two groups (P>0.05). At 12 months of follow-up, there was no recurrence in either the experimental or control group. @* Conclusions @#3D digital guide plate-guided percutaneous microballoon compression for primary trigeminal neuralgia can improve the accuracy and safety of puncture to a certain extent, obviously shorten the operation time, reduce radiation exposure of the patients, improve the success rate of the operation, meaning it has a high clinical application value.

10.
Analyst ; 147(22): 4971-4979, 2022 Nov 07.
Article in English | MEDLINE | ID: mdl-36205380

ABSTRACT

Antigen tests for SARS-CoV-2 are widely used by the public during the ongoing COVID-19 pandemic, which demonstrates the societal impact of homogeneous immunosensor-related technologies. In this study, we used the PM Q-probe and Quenchbody technologies to develop a SARS-CoV-2 nucleocapsid protein (N protein) homogeneous immunosensor based on a human anti-N protein antibody. For the first time, we uncovered the crowding agent's role in improving the performance of the double-labeled Quenchbody, and the possible mechanisms behind this improvement are discussed. The 5% polyethylene glycol 6000 significantly improved both the response speed and sensitivity of SARS-CoV-2 Quenchbodies. The calculated limit of detection for recombinant N protein was 191 pM (9 ng mL-1) within 15 min of incubation, which was 9- to 10-fold lower than the assay without adding crowding agent. We also validated the developed immunosensor in a point-of-care test by measuring specimens from COVID-19-positive patients using a compact tube fluorometer. In brief, this work shows the feasibility of Quenchbody homogeneous immunosensors as rapid and cost-efficient tools for the diagnosis and high-throughput analysis of swab samples in large-scale monitoring and epidemiological studies of COVID-19 or other emerging infectious diseases.


Subject(s)
Biosensing Techniques , COVID-19 , Humans , SARS-CoV-2 , COVID-19/diagnosis , Pandemics , Immunoassay , Nucleocapsid Proteins
11.
Sci Total Environ ; 836: 155380, 2022 Aug 25.
Article in English | MEDLINE | ID: mdl-35489509

ABSTRACT

Upsurge of glacier-related hazards in High Mountain Asia (HMA) has been evident in recent years due to global warming. While many glacial-related hazards are instantaneous, some large landslides were preceded by slow gravitational deformation, which can be predicted to evade catastrophes. Here, we present robust evidence of historical deformation in 2021 Chamoli rock-ice avalanche of Himalaya using space imaging techniques. Multi-temporal satellite data provide evidence of a precursor event in 2016 and expansion of a linear fracture along joint planes, indicating 2021 rock-ice avalanche is a retrogressive wedge failure. The deformation history shows that the fracture propagated at a velocity of ~0.07 m day-1 until September 2020, and with an accelerated velocity (~0.14 m day-1 on average) lately. Analysis of recent similar cases in HMA supported our inference on global warming-induced glacier retreat and thermomechanical effects in enhancing the weakening of fractured rock masses in tectonically active mountain belts. Recent advances in Earth observation and seismic monitoring system can offer clues to the location and timing of impending catastrophic failures in high mountain regions.


Subject(s)
Avalanches , Landslides , Asia , Global Warming , Ice Cover
12.
ACS Appl Mater Interfaces ; 14(17): 19226-19240, 2022 May 04.
Article in English | MEDLINE | ID: mdl-35446537

ABSTRACT

The competition between cells integration and bacterial colonization determines the fate of implantations. To reveal the effects of clinical implant topographies on osteoblast differentiation and bacterial biofilm formation, a series of micron/submicron/nano-hierarchical structures were created at pure titanium surfaces (Ti-I, Ti-II, Ti-III). It was found that the hierarchical structures promoted MC3T3-E1 cell differentiation through contact guidance and Ti-II processed the best osteogenic ability. Undesirably, hierarchical surfaces further accelerated the biofilm formation due to submicron structures with low interaction. To reduce the risk of bacterial infections, hierarchical structures were prepared on the antibacterial Cu-bearing titanium alloy surfaces (TiCu-I, TiCu-II, TiCu-III). Hierarchical topographies not only endowed TiCu surfaces with antibacterial trapping characteristics due to CuO doped in the outermost oxides layer but also shifted the corrosion behavior of TiCu alloy into activation-passivation, increasing the Cu-ion release rate and further promoting the osteogenic differentiation. TiCu-III possessed excellent antibacterial trapping ability and optimal osteogenic action. Finally, in the osteomyelitis-modeled mice, hierarchical topographies aggravated the bacterial infection around Ti implants, which entirely lost the osseointegration, while all of the TiCu surfaces significantly inhibited the infection and accelerated the formation of new bone tunnels around the implants. In vivo studies successfully confirmed the tuning mechanism of hierarchical topographies on the biological responses of bacteria and cells to the Ti and TiCu alloys, which would pave the way to develop novel biofunctionalized metal implants.


Subject(s)
Alloys , Bacterial Infections , Alloys/pharmacology , Animals , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Bacteria , Mice , Osseointegration , Osteogenesis , Surface Properties , Titanium/chemistry , Titanium/pharmacology
13.
Org Lett ; 24(11): 2104-2109, 2022 Mar 25.
Article in English | MEDLINE | ID: mdl-35290069

ABSTRACT

This report developed a method for the synthesis of C8-aminated pyrrolo-phenanthridines or -indoles by series ortho C(sp2)-H amination/ipso C(sp2)-H or C(sp3)-H arylation. N-benzoyloxyamines, as electrophilic amination reagents, did not undergo an electrophilic substitution reaction with the pyrrole side, but they did undergo a site-selective C-H amination reaction with the benzene side via Pd/NBE catalysis. The C8-aminated pyrrolo-phenanthridines have strong fluorescence in solution and solid state. X-ray single crystal diffraction shows that the steric hindrance of amino and ortho benzene ring may inhibit aggregation-caused quenching (ACQ).

14.
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-936411

ABSTRACT

Objective @# investigate the correlation between the ossification of the styloid hyoid ligament and Bell’s facial paralysis and provide a reference for clinical diagnosis and treatment.@* Methods@# A case of ossification of the bilateral stylohyoid ligament with Bell's facial palsy caused by ossification of the bilateral stylohyoid ligament was diagnosed by clinical manifestations, differential diagnosis and imaging examination. The surgical plan was determined, and combined surgical resection of the ossified area of the styloid hyoid ligament and the greater horn of the hyoid was performed. Postoperative cefoxitin sodium anti-inflammatory treatment, methylprednisolone hormone treatment, acyclovir antiviral treatment, mecobalamin nutritional neurotherapy, and the relevant literature were analyzed. @* Results@# The patient experienced pain when swallowing before surgery, disappearance of right frontal ridges, incomplete eyelid closure, and ptosis of mouth corners. An MRI scan of the brain excluded intracranial space-occupying lesions and resulted in the diagnosis of Bell’s facial paralysis. High-resolution CT of the styloid process confirmed ossification of the styloid hyoid ligament. Styloid process shortening and partial hyoid resection were performed under general anesthesia. Half a month after discharge, the symptoms of sore throat and pain in swallowing disappeared, facial nerve function recovered well, right eyelid closure function recovered well, and right mouth droop improved. The facial nerve function basically returned to normal after 1 month of follow-up. A review of the relevant literature showed that ossification of the stylohyoid ligament to form pseudojoint dilation can locally stimulate the peripheral facial nerve and lead to facial paralysis symptoms. @*Conclusion@# Ossification of the styloid hyoid ligament is usually characterized by pharyngeal pain, which can be confirmed by imaging examination. Ossification of the styloid hyoid ligament with facial paralysis is rare in the clinic, so it is necessary to make a clear diagnosis and treat the symptoms.

15.
ACS Appl Mater Interfaces ; 13(41): 48691-48699, 2021 Oct 20.
Article in English | MEDLINE | ID: mdl-34617438

ABSTRACT

The lithium (Li)-metal anode is deemed as the "holy gray" of the next-generation Li-metal system because of its high theoretical specific capacity, minimal energy density, and lowest standard electrode potential. Nevertheless, its commercial application has been limited by the large volume variation during charge and discharge, the unstable interface between the Li metal and electrolyte, and uneven deposition of Li. Herein, we present a 3D host (Cu) with lithiophilic matrix (CuO and SnO2) in situ modification via a facile ammonia oxidation method to serve as a current collector for the Li-metal anode. The 3D Cu host embellished by CuO and SnO2 is abbreviated as 3D CSCC. By increasing interfacial activity, lowering the nucleation barrier, and accommodating changes in volume of the Li metal, the 3D CSCC electrode effectively demonstrates a homogeneous and dendrite-free deposition morphology with an excellent cycling performance up to 3000 h at a 1.0 mA cm-2 current density. Additionally, the full cells paired with Li@3D CSCC anodes and LiCoO2 cathodes show good capacity retention performance at 0.2 C.

16.
Org Lett ; 23(19): 7518-7523, 2021 Oct 01.
Article in English | MEDLINE | ID: mdl-34505792

ABSTRACT

In palladium/norbornene (Pd/NBE) chemistry, the "ortho effect" has been proven to be a key factor in the process of ß-carbon elimination to extrude NBE. Herein, we found that the o-iodoaniline protected by a p-methoxybenzenesulfonyl group can recover the "ortho effect" and then undergo N-S bond cleavage with vinyl palladium, thus achieving a highly selective C-N coupling reaction in the Catallani-Lautens reaction system. On the basis of this discovery, a one-step synthesis of highly functionalized tricyclic indole derivatives was realized.

17.
J Infect ; 83(1): 46-53, 2021 07.
Article in English | MEDLINE | ID: mdl-34048821

ABSTRACT

BACKGROUND: We aimed to address the knowledge gap that exists regarding the epidemiological, demographic, and clinical characteristics of nontuberculous mycobacterial pulmonary diseases (NTM-PDs) among smear-positive patients with symptoms suggestive of pulmonary tuberculosis (PTB) in China. METHODS: Prospective and national surveillance of NTM-PD was performed from 17 hospitals within the China Nontuberculous Mycobacteria Surveillance Study (CNTMS). Patients were eligible for inclusion if they had positive smears during hospitalization. Sputum specimens were collected for molecular species identification. RESULTS: 6,766 patients with valid results were included, consisting of 6,236 (92.2%) with PTB, 458 (6.8%) with NTM-PD, and 72 (1.0%) with colonization. The proportion of NTM-PD in PTB patients exhibited significant geographic diversity, ranging from 3.2% in the northwest to 9.2% in the south. The most prevalent species was Mycobacterium intracellulare, followed by Mycobacterium abscessus complex. Females, elderly people, and patients with bronchiectasis or COPD are at high risk for developing NTM-PD, while patients with diabetes have a lower risk of NTM-PD when compared with non-diabetic patients. Regarding clinical symptoms, lower rates of persistent cough and weight loss were noted in NTM-PD patients than in PTB patients. CONCLUSIONS: Approximately one-fifteenth of PTB patients are afflicted with nontuberculous mycobacterial infections in China. The prevalence of NTM shows geographic diversity across the country, and it showed a gradual increase from north to south and from west to east. NTM-PD patients are prone to exhibit less severe clinical symptoms than PTB patients, highlighting the importance of raising awareness of NTM diseases to improve decision making on how to best screen, diagnose, and treat NTM in TB-endemic settings.


Subject(s)
Mycobacterium Infections, Nontuberculous , Tuberculosis, Pulmonary , Aged , China/epidemiology , Female , Humans , Mycobacterium Infections, Nontuberculous/epidemiology , Nontuberculous Mycobacteria , Prospective Studies , Risk Factors , Tuberculosis, Pulmonary/epidemiology
18.
Bioact Mater ; 6(4): 916-927, 2021 Apr.
Article in English | MEDLINE | ID: mdl-33210018

ABSTRACT

Copper is an indispensable trace metal element in the human body, which is mainly absorbed in the stomach and small intestine and excreted into the bile. Copper is an important component and catalytic agent of many enzymes and proteins in the body, so it can influence human health through multiple mechanisms. Based on the biological functions and benefits of copper, an increasing number of researchers in the field of biomaterials have focused on developing novel copper-containing biomaterials, which exhibit unique properties in protecting the cardiovascular system, promoting bone fracture healing, and exerting antibacterial effects. Copper can also be used in promoting incisional wounds healing, killing cancer cells, Positron Emission Tomography (PET) imaging, radioimmunological tracing and radiotherapy of cancer. In the present review, the biological functions of copper in the human body are presented, along with an overview of recent progress in our understanding of the biological applications and development of copper-containing materials. Furthermore, this review also provides the prospective on the challenges of those novel biomaterials for future clinical applications.

19.
Org Lett ; 22(21): 8267-8271, 2020 Nov 06.
Article in English | MEDLINE | ID: mdl-33048560

ABSTRACT

This paper describes the case of a cross study between the C-N bond cleavage reaction field and the Catellani-Lautens reaction system. A series of highly functionalized C4-substituted indoles were synthesized using this strategy. By screening the alkyl groups of amines, the energy barrier of C-N bond cleavage reaction was reduced and the corresponding allenization products were avoided. Finally, the density functional theory calculation shows that the inert C-N bond activation reaction is not a concerted process; on the contrary, the coupling reaction first generates indole quaternary ammonium salt, and then C-N bond cleavage occurs via an SN2 process.

20.
ACS Omega ; 5(34): 21488-21496, 2020 Sep 01.
Article in English | MEDLINE | ID: mdl-32905499

ABSTRACT

Transition-metal oxides are attracting considerable attention as anodes for lithium-ion batteries because of their high reversible capacities. However, the drastic volume change and inferior electrical conductivity greatly retard their widespread applications in lithium-ion batteries. Herein, three-dimensional nanoporous composites of CoO x (CoO and Co3O4) quantum dots and zeolitic imidazolate framework-67-derived carbon are fabricated by a precipitation method. The carbon prepared by carbonization of zeolitic imidazolate framework-67 can greatly enhance the electrical conductivity of the composite anodes. CoO x quantum dots anchored firmly on zeolitic imidazolate framework-67-derived carbon can effectively inhibit the aggregation and volume change of CoO x quantum dots during lithiation/delithiation processes. The nanoporous structure can shorten the ion diffusion paths and maintain the structural integrity upon cycling. Meanwhile, kinetics analysis reveals that a capacitance mechanism dominates the lithium storage capacity, which can greatly enhance the electrochemical performance. The composite anodes show a high discharge capacity of 1873 mAh g-1 after 200 cycles at 200 mA g-1, ultralong cycle life (1246 mAh g-1 after 900 cycles at 1000 mA g-1), and improved rate performance. This work may provide guidelines for preparing cobalt oxide-based anodes for LIBs.

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