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Mar Drugs ; 12(6): 3371-80, 2014 Jun 03.
Article in English | MEDLINE | ID: mdl-24897385

ABSTRACT

Four new cembrane-type diterpenes; numerosol A-D (1-4); along with a known steroid; gibberoketosterol (5); were isolated from the Taiwanese soft coral Sinularia numerosa. The structures of these metabolites were determined by extensive analysis of spectroscopic data. Gibberoketosterol (5) exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 6.9 µM.


Subject(s)
Anthozoa/metabolism , Antineoplastic Agents/pharmacology , Diterpenes/pharmacology , Leukemia P388/drug therapy , Animals , Antineoplastic Agents/chemistry , Antineoplastic Agents/isolation & purification , Cell Line, Tumor , Diterpenes/chemistry , Diterpenes/isolation & purification , Drug Screening Assays, Antitumor , Humans , Leukemia P388/pathology , Mice , Sterols/chemistry , Sterols/isolation & purification , Sterols/pharmacology , Taiwan
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