1.
Chem Commun (Camb)
; 60(14): 1904-1907, 2024 Feb 13.
Article
in English
| MEDLINE
| ID: mdl-38258986
ABSTRACT
A novel method has been developed for the synthesis of 1-methyl-4,5-diaryl-1H-imidazoles through Fe(II)-catalyzed cyclization of 2H-azirines and N,N-dimethylformamide (DMF) as an amine source. This transformation involves the cleavage of C-N and CîN double bonds and the construction of new C-N and CîN double bonds. The reaction has readily available starting materials, a wide range of substrates and mild reaction conditions. In addition, the reaction also facilitated the convenient synthesis of 1-methyl-2,4,5-triaryl-1H-imidazoles.