ABSTRACT
AIMS: Increased intra-abdominal pressure (IAP) is now considered a potential contributor to organ damage and disease progression in acute heart failure (AHF). In this work, we aimed to determine if antigen carbohydrate 125 (CA125) is associated with IAP and to identify a cutpoint of CA125 useful for ruling out intra-abdominal hypertension (defined as IAP ≥ 12â mmHg). METHODS AND RESULTS: We prospectively evaluated a cohort of 53 patients admitted with AHF in which IAP was measured within the first 24-h of admission. The mean age was 80 ± 8 years, 31 (58.5%) were female, and 31 (58.5%) had left ventricular ejection fraction ≥50%. The median plasma levels of NT-proBNP and CA125 were 3830â pg/mL (2417-8929) and 45.8â U/mL (29.8-114.0), respectively. The median of IAP was 15â mmHg (11-17), and 39 (73%) patients had an IAP ≥ 12â mmHg. The diagnostic performance of CA125 for identifying an IAP ≥ 12â mmHg was tested using the receiving operating characteristic (ROC) curve. The cut-off for CA125 of 17.1â U/mL showed a sensitivity of 92%, a specificity of 50%, and an area under the ROC curve of 0.71. After multivariate adjustment, CA125 remained non-linearly and positively associated with higher IAP (P-value = 0.003), explaining almost 28% of the model's variability (R2: 27.6%). CONCLUSIONS: Patients with AHF and intra-abdominal hypertension had higher CA125 plasma levels. A baseline concentration of CA125 below 17.1â U/mL will increase the odds of identifying a subset of patients with normal IAP.
Subject(s)
Heart Failure , Intra-Abdominal Hypertension , Aged , Aged, 80 and over , Carbohydrates , Female , Humans , Intra-Abdominal Hypertension/diagnosis , Male , Stroke Volume , Ventricular Function, LeftABSTRACT
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Subject(s)
Humans , Male , Middle Aged , Urinary Tract/diagnostic imaging , Urinary Tract/injuries , Wounds and Injuries/therapy , Wounds and Injuries/diagnostic imaging , Accidents, Occupational , Tomography, X-Ray Computed , Extravasation of Diagnostic and Therapeutic Materials , Severity of Illness IndexABSTRACT
No disponible
Subject(s)
Humans , Male , Aged, 80 and over , Urinary Bladder Diseases/etiology , Cystocele/diagnostic imaging , Abscess/complications , Cystocele/drug therapy , Testicular Diseases/complications , Testicular Diseases/diagnostic imaging , Scrotum/diagnostic imaging , Testis/diagnostic imaging , Testis/pathology , Enterococcus faecalis/isolation & purification , Escherichia coli/isolation & purification , Anti-Bacterial Agents/therapeutic useABSTRACT
No disponible
Subject(s)
Humans , Male , Adolescent , Urachal Cyst/diagnostic imaging , Pain/etiology , Urachus/diagnostic imaging , Tomography, X-Ray Computed , Scrotum/diagnostic imagingABSTRACT
No disponible
Subject(s)
Humans , Cystitis/diagnosis , Emphysema/diagnosis , Urinary Tract Infections/diagnosisABSTRACT
No disponible
Subject(s)
Humans , Female , Aged , Diagnosis, Differential , Tarsal Tunnel Syndrome/surgery , Tarsal Tunnel Syndrome , Tibial Nerve/pathology , Tibial Nerve , Ankle/pathology , Ankle , Fasciitis, Plantar , Paresthesia/complicationsSubject(s)
Nerve Compression Syndromes/diagnosis , Tibial Neuropathy/diagnosis , Aged , Female , Foot , HumansABSTRACT
Fallopian tube cancer is the less frequent gynecological cancer. It occurs typically between 40 and 65 years old. Diagnosis is usually achieved earlier than in ovarian cancer cases, due to early symptoms (typically abdominal pain, hydro-hematorrhea and adnexal mass). Preoperative correct diagnosis is infrequent, being most cases diagnosed during the surgery or in the pathological study. Histologically and clinically is similar to ovarian cancer, being the serous low differentiated the most frequent type. An early suspicion and a correct intervention are essential to obtain correct diagnosis and treatment. Treatment protocols are similar to those of ovarian cancer recommended by the FIGO.
Subject(s)
Adnexal Diseases/etiology , Carcinoma/complications , Fallopian Tube Neoplasms/complications , Torsion Abnormality/etiology , Female , Humans , Middle AgedABSTRACT
No disponible