Discussion on strengthening the cultivation of medical students' innovation ability based on the scientific research platform of college teachers / 中华医学教育探索杂志

The cultivation of medical students' scientific research and innovation ability is the need of our country to accelerate the construction of an innovative country. This paper starts from the significance of strengthening the cultivation of medical students' scientific research and innovation ability, emphasizes participation in teacher's scientific research in colleges and universities to strengthen the feasibility of the medical students' scientific research and innovation ability cultivation, and summarizes the practical experience of cultivating medical students' scientific research ability based on scientific research projects of teachers in colleges and universities, which can provide reference for peers.

Role of prediction error in destabilizing fear memories in retrieval extinction and its neural mechanisms.

Memory reconsolidation interference has been shown to be an effective way to neutralize conditioned fear memory and prevent relapse. The critical factor to utilize this paradigm is inducing a labile state of the long-term memory. Novel information is viewed as a driving factor to update memory; however, it is unknown whether different forms of novelty play the same role. In addition, although pharmacological intervention studies have confirmed that prediction error (PE) during reactivation is a necessary condition in memory destabilization, the role of PE in retrieval extinction has remained under debate; furthermore, the neural mechanisms underlying the process are largely unknown. In this study, we isolated two forms of novelty: PE and stimulus novelty without PE during reactivation to compare their role in memory lability. Skin conductance responses (SCR) and functional magnetic resonance imaging (fMRI) were used to clarify their role at the behavioural and neural mechanism levels. A total of 54 healthy adults were tested in a three-day retrieval extinction protocol. The results showed that PE, the novelty of CS-US combinations, was a critical condition to destabilize memory. The novelty of the stimulus itself with the absence of PE was insufficient for retrieving the memory. The neural mechanisms that distinguished standard extinction from retrieval extinction were that the latter was associated with a diminished recruitment of the inferior temporal cortex (IT) and dorsolateral prefrontal cortex (dlPFC) and decreased functional connectivity of the dlPFC-anterior cingulate cortex (ACC) and IT-dlPFC. Possible interpretations were discussed.