ABSTRACT
We analyzed the expression of galectin-1 and galectin-3 in tumor tissue in stomach and colorectal cancer with and without tissue eosinophilia. Low expression of galectin-3 was detected in all patients with malignant gastrointestinal tumors irrespective of the presence of eosinophilia. Low expression of galectin-1 was detected only in patients with gastrointestinal cancer associated with eosinophilia. Association of galectin-1 expression with eosinophilic infiltration of the tumor tissue in stomach and colorectal cancer was detected.
Subject(s)
Colorectal Neoplasms/metabolism , Eosinophilia/metabolism , Galectin 1/metabolism , Galectin 3/metabolism , Aged , Blood Proteins , Chemotaxis, Leukocyte/physiology , Cohort Studies , Colorectal Neoplasms/complications , Colorectal Neoplasms/pathology , Eosinophilia/complications , Eosinophilia/pathology , Eosinophils/metabolism , Eosinophils/pathology , Galectins , Gastric Mucosa/metabolism , Humans , Middle Aged , Stomach/pathology , Stomach Neoplasms/metabolism , Stomach Neoplasms/pathologyABSTRACT
A real-time PCR with hybridization and fluorescent detection was used to analyze the distribution of p53 G215C, p21A1026G, and G369C gene polymorphisms in patients with stomach cancer and healthy subjects. It was found that allele C, genotypes of CC and GC of G215C p53, and G369C p21 polymorphisms and allele A and AA and GA genotypes of A1026G p21 polymorphism are significantly associated with the risk of stomach cancer development.
Subject(s)
Cyclin-Dependent Kinase Inhibitor p21/genetics , Stomach Neoplasms/genetics , Tumor Suppressor Protein p53/genetics , Aged , Case-Control Studies , Female , Gene Frequency , Genetic Association Studies , Genetic Predisposition to Disease , Humans , Male , Middle Aged , Polymorphism, Single Nucleotide , Risk FactorsABSTRACT
There were studied distribution of polymorphic variants of gene of repair of DNA XPD A751C in lung cancer depending on histological type of tumor (small cell / non-small cell lung cancer) and the prevalence of tumor process (with foci / without foci of metastasis). It was found a significant increase in the incidence of minor allele C, CC and AC genotypes of the polymorphic site of gene XPD A751C in patients with lung cancer. We estimated relative risks of lung cancer development in carriers of polymorphic variants of gene XPD A751C. The heterozygous genotype AC polymorphism of gene XPD A751C is characterized by the greatest risk of developing lung cancer with small cell histological type. Homozygous CC genotype of the polymorphic site of gene XPD A751C is associated with non-small cell lung cancer development. Statistically significant differences in the distribution of polymorphic variants of gene A751C XPD depending on spread of cancer were not received.
Subject(s)
Genetic Association Studies , Genetic Predisposition to Disease , Lung Neoplasms/genetics , Xeroderma Pigmentosum Group D Protein/genetics , Alleles , DNA Repair/genetics , Female , Genotype , Heterozygote , Humans , Lung Neoplasms/pathology , Male , Middle Aged , Polymorphism, Single Nucleotide/genetics , Risk FactorsABSTRACT
The review provides information on current literature on structural and functional features of eosinophilic granulocytes and their role in the pathogenesis of cancer. There are examined data of clinical and experimental studies about an influence of hemic and tissue eosinophilia on the course and prognosis of malignant tumors. Molecular mechanisms of action of eosinophils in tumor pathology are discussed.
