ABSTRACT
In the recent years,the earthquake occured frequently in the whole world which caused the increased incidence of crush syndrome (CS). The four limbs and torso will be bleeding and swelling when they are prounded and crushed from the heavy objects. The necrosis of muscular tissue causes massive production of toxin which leads to a series of symptoms including hypotension ,kidney dysfunction and so on. The serious acute kidney injury (AKI) will be vital. When CS-AKI ,the ascending velocity of urea nitrogen and K+ levels in the blood is quicker than those of general AKI;many kinds of immune cells are activated to engender a great deal of inflammatory mediators;the blood dynamics is often unstable. Therefore, it is advocated that the blood purification treatment should be carried early to eliminate excessive metabolic produces in vivo,to reduce the cardiovascular complication occurrence, and to avoid the irreversible change of the kidney function.
ABSTRACT
It has been suggested that renin-angiotensin system (RAS) gene polymorphism is involved in the pathogenesis of Henoch-Schönlein purpura (HSP) with conflicting reports. We therefore investigate the effect of RAS gene polymorphism on HSP susceptibility and severity in a Chinese cohort. The study included 142 children with HSP and 218 healthy controls that were genotyped for RAS gene polymorphisms. Significantly, differences of T174M-T and ACE-D frequency were found between HSP patients and controls (p(alleo) = .002, OR(alleo) = 2.001; p(alleo) = .007, OR(alleo) = 1.533, respectively). We also found correlations between ACE-I/D and Agt T174M with multiple organ involvements, with significant differences in ACE-D in renal groups (p < 0.05) and Agt T174M in non-renal (p(joint) = .002, p(GI) = .042). Furthermore, decreasing M235T-T and increasing ACE-D were found associated with serious renal complications (p = .019, p = .016). Additionally, ACE-I/D and T174M were significantly associated with high clinical score patients, as opposed to low clinical score patients, when patients were scored depending on the severity of overall complications (p = .045, p = .026). We suggest that RAS gene polymorphisms (ACE-I/D, M235T or T174M) are significantly associated with susceptibility to HSP, organ involvement, and disease severity, which largely account for individual prognosis.
Subject(s)
Genetic Predisposition to Disease , IgA Vasculitis/genetics , Polymorphism, Genetic , Renin-Angiotensin System/genetics , Adolescent , Case-Control Studies , Child , Child, Preschool , China , Female , Gene Frequency/genetics , Humans , INDEL Mutation/genetics , IgA Vasculitis/complications , Kidney/pathology , Male , Organ Specificity/geneticsABSTRACT
The construction of standardized and specialized computer room is the base of hospital digitization and informatization.It should follow the national and specialized standards to assure a good condition for the data center,put together the knowledge of multi-disciplines and advanced technologies,and adopt reasonable design and rigid construction.This article discusses the construction of computer room in terms of the principles,elements and co-ordination
ABSTRACT
How to choose appropriate medical matrix and correctly and flexibly master retrieval method are the key factors to get valuable information.The usual medical matrixes on internet are collected and analyzed.According to the requirement of the user,retrieval routes and techniques are introduced.Some advices are also given on the present situation of Chinese medical matrix.The purpose is to help medical personnel to select proper medical matrix for desired information.
