ABSTRACT
Objective To investigate the protective effect of Jiejiu oral liquid on acute alcohol-induced gastric mucosal lesions in mice.Methods Sixty Knming''s mice were randomly divided into normal control group,model control group,sucralfate group(600 mg·kg-1),the dose of 25.0 g·kg-1 group,the dose of 12.5 g·kg-1 group and the dose of 6.25 g·kg-1 group of the Jiejiu oral liquid (n=10 each).Except for the normal control group,other groups were intragastrically administered with 95% ethanol to create the alcohol-induced acute gastritis model.The effect of pathological histology,injury of gastric mucosa,the mucosal NO,ET-1,TNF-α,IL-6 and PGE2 content of acute alcohol-induced gastric mucosal lesions in mouse were observed.Results The gastric mucosa in model control group appeared obvious bleeding,erosion,and flake ulcer.Compared with the model control group,the acute damage index of the Jiejiu oral liquid therapy groups were obviously reduced (P0.05).Histopathologic examination revealed Jiejiu oral liquid can reduce the shedding of gastric mucosa and inflammatory cells infiltration.Conclusion The Chinese herbal mixture Jiejiu oral liquid has a protective effect on acute alcohol-induced gastric mucosal lesions in mice.
