Improvement of Mechanical Properties of Personalized Insole Manufactured with Selective Laser Sintering Based on Process Parameter Optimization and Cell Structure Design.

Personalized insoles manufactured with selective laser sintering (SLS) technology are popular especially for exercisers and patients with foot diseases. However, insufficient strength and toughness of personalized insoles would result in crack and even fracture. To address these deficiencies and fill the research shortages in this area, optimization of process parameters and design of cell structures are conducted to improve the mechanical performance of insoles in this topic. First, six sets of process parameters in terms of energy density were designed for parameter optimization. The energy density of 0.08 J/mm2 was affirmed to be the finest selection. Then, specific cell structures featuring both whale shark and ancient soldier armor (WS structures for short) with various curvature radius were established to act on the bottom of the insole to further strengthen the personalized insoles. It was shown that the WS14 structure exhibited the best performance characteristics. Finally, a personalized insole with the array of WS14 structures was developed with SLS under the optimum energy density of 0.08 J/mm2. Finite element method analysis and exercising testing were performed to evaluate the insole performance. The result reveals that a more uniform stress distribution is attained of the WS14 personalized insole, and the fracture problem is indeed solved.

Characterization of PA12/HA composite scaffolds based on selective laser sintering.

Composite scaffolds have been extensively studied in bone tissue engineering, which can achieve excellent properties that cannot be obtained by a single material. In this study, the effect of hydroxyapatite (HA) on the reliability of polyamide 12 (PA12) scaffold for bone graft was explored in terms of mechanical and biological properties. Thermal properties testing showed that no physical or chemical reaction occurs in the prepared PA12/HA composite powders. Further, compression experiments showed that adding a small amount of HA promoted the mechanical properties of the scaffold, while excessive HA results in agglomeration and impairs the PA12/HA scaffold. For the scaffolds with the porosity of 65%, the 96% PA12/4% HA scaffold has a 7.3% higher yield strength and a 13.5% higher compressive modulus than the pure PA12 scaffold while the strength of the 88% PA12/12% HA scaffold decreases by 35.6%. Furthermore, contact angle and CCK-8 tests confirmed that 96% PA12/4% HA scaffold effectively improved the hydrophilicity and biocompatibility of the scaffold. Its OD value on the 7th day is 0.949, which is significantly higher than that of other groups. In summary, PA12/HA composites have good mechanical properties and biocompatibility, which can be used as an effective strategy in bone tissue engineering.

Mechanical properties and failure mechanisms of polyamide 12 gradient scaffolds developed with selective laser sintering.

Developing a functional gradient scaffold compatible with the fantastic biological and mechanical properties of natural bone tissue is imperative in bone tissue engineering. In this work, the stretch-dominated (cubical and circular) and bending-dominant (diamond and gyroid) pore styles were employed to design custom-graded scaffolds based on the curve interference method and then were fabricated by selective laser sintering (SLS) using polyamide 12 (PA12) powder. Subsequently, the mechanical behavior, failure mechanism, and energy absorption performance of porous structures were investigated via compression experiments and finite element (FE) simulation. The results indicated that the stretch-dominated radial gradient structures entire exhibited transverse shear failure and the bending-dominant radial gradient structures whole exhibited progressive destruction, while all of the axial gradient scaffolds suffered a predictable layer-by-layer fracture. Among them, the bending-dominated radial gradient structure of gyroid had been proven to sustain stronger deformability and energy absorption capacity. Meanwhile, the FE method powerfully predicted the mechanical behavior of the scaffold, and this research thereby possessed significant implications for the development of bone tissue engineering.

Mechanical and permeability properties of porous scaffolds developed by a Voronoi tessellation for bone tissue engineering.

Irregular porous structures for guided bone regeneration applications have gained increasing attention as they are similar to human bone and more suitable for bone tissue growth. However, pore irregularity as a critical characteristic has been poorly explored. This study proposed a method for parametrically designing porous scaffolds based on a Voronoi tessellation which were manufactured by selective laser sintering (SLS) using the polyamide 12 (PA12) material. The deformation mechanism and energy absorption properties of the prepared Voronoi scaffolds were investigated by quasi-static compression experiments. The results demonstrated that the Voronoi scaffold underwent bending deformation subsequent to transverse expansion under compression, and the Voronoi scaffold simultaneously had been indicated to be effective in improving the carrying capacity and energy absorption performance. Subsequently, computational fluid dynamics (CFD) and cell proliferation tests were introduced to comprehensively assess the influence of the scaffolds on cell growth. CFD analysis showed that the permeability of the surveyed scaffolds is between 3.65 × 10-8 and 12.05 × 10-8 m2 similar to that of natural cancellous bone. The cell test expressed that the scaffold exhibits good cell activity, which can be used to promote cell adhesion and migration with superior potential for development and application.