ABSTRACT
BACKGROUND: Several records have reported that single nucleotide polymorphism (SNP) at the interleukin 10 (IL-10)-1082G/A locus affects the risk of acute lung injury/respiratory distress syndrome (ALI/RDS), but the exact association between them has not been elucidated. OBJECTIVE: This systematic review aims to elucidate the relationship between SNP at the IL-10-1082G/A locus and susceptibility to ALI/RDS by the method of meta-analysis, to identify the early warning indicators of ALI/RDS. METHODS: Studies on IL-10-1082G/A SNP associated with ALI/RDS were obtained by thorough retrieval of four English databases from each database construction to April 1, 2022. We processed the data using Stata 15.0 software. RESULTS: Eight eligible records were entered into this meta-analysis. The pooled analysis demonstrated that SNP at the IL-10-1082G/A locus contributed to the risk of ALI/RDS in the allelic (G vs. A: OR= 0.74, 95%CI: 0.55â¼0.98) and recessive gene models (Genotype GG vs. GA+AA: OR= 0.57, 95%CI: 0.35â¼0.93). The subgroup analysis based on case type showed that SNP at IL-10-1082G/A locus contributed to the risk of neonatal respiratory distress syndrome (NRDS) under all the gene models (Allele G vs. A: OR= 0.45, 95%CI: 0.29â¼0.72; Genotype GG+GA vs. AA: OR= 0.36, 95%CI: 0.22â¼0.58; Genotype GG vs. GA+AA: OR= 0.30, 95%CI: 0.09â¼0.97; Genotype GA vs. AA: OR= 0.44, 95%CI: 0.27â¼0.73), except the homozygous model. However, it was not found that SNP at the IL-10-1082G/A locus contributed to ALI or acute respiratory distress syndrome (ARDS). Moreover, the risk of ALI/RDS in Asia was associated with the IL-10-1082G/A locus in the allelic, recessive, and heterozygous models, while we did not observe this association across the Caucasian populations. CONCLUSION: SNP at the IL-10-1082G/A locus contributed to the risk of ALI/RDS, allele G and genotype GG increasing the ALI/RDS risk, especially in Asia. Besides, allele G, genotype GG+GA, GG, and GA at the IL-10-1082G/A locus can increase susceptibility to NRDS.
