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Bioorg Med Chem
; 19(10): 3120-7, 2011 May 15.
Article
in English
| MEDLINE
| ID: mdl-21524588
ABSTRACT
A series of tryptamine derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in the HepG2.2.15 cell line. The preliminary SAR was discussed. Compounds 2e and 4a showed potent antiviral activity (IC(50)=0.4 and <1 µM, respectively) and low cytotoxicity (CC(50)=40.6 and >25 µM, respectively).