1.
Org Biomol Chem
; 9(17): 6082-8, 2011 Sep 07.
Article
in English
| MEDLINE
| ID: mdl-21748192
ABSTRACT
Silver acetylides and organic azides react under copper(I) catalysis to afford 1,4-disubstituted 1,2,3-triazoles. Mechanistic studies implicate a process involving transmetallation to copper acetylides prior to cycloaddition. This work demonstrates that silver acetylides serve as suitable precursors for entry into copper-mediated coupling reactions. This methodology allows the incorporation of volatile and difficult-to-handle acetylenes into the triazole core.