[Bacterial translocation from the gastrointestinal tract: catalyst of multiple organ dysfunction syndrome]. / Bakterialna translokatsiia ot gastrointestinalniia trakt: katalizator na sindroma na multiplena organna disfunktsiia.

The abnormal colonization of gastrointestinal tract (GIT), the loss of the intestinal barrier function, the bacterial translocation (BT) are signs of intestinal insufficiency which are supposed to be involved in the pathogenesis of MODS. This worsens the condition or leads to lethal outcome in patients after major abdominal surgery in ICU. The goal of this investigation was to consider the scientific and clinical evidence for the BT role in the pathogenesis of MODS and to present evidence about the advantages and the efficiency of antibiotic combination Amikacin plus Clindamycin as a new therapeutic strategy for the improvement of the outcome in patients with MODS and sepsis. To that purpose patients with diffuse peritonitis of different origin were analyzed. After surgery some patients were left with laparostomy. This gave the possibility for revisions and lavages of the abdominal cavity and for taking material for microbiological analyses. The patients were grouped into two subgroups according to antibiotic treatment: 1st group--combination of usually used antibiotics; 2nd group--Amikacin plus Clindamycin. The second group patients showed good tolerance to this antibiotic combination and good therapeutic effect.

[The role of low molecular weight heparin (fragmin) in the prophylaxis and treatment of venous thromboembolism in major abdominal operations]. / Miastoto na inskomolekuliarnite kheparini (fragmin) v profilaktikata i lechenieto na venozniia tromboemboliz'm pri golemi koremni operatsii.

The goal of the authors was to prepare a thorough survey of the publications about the application of low molecular weight heparines in deep venous thromboses and pulmonary embolism after abdominal surgery. Several low molecular weight heparines have been introduced in clinical practice since 1980. Till then only standard heparin has been used for deep thromboses prevention. Both drugs have the same or similar anticoagulant or antithrombotic effect. Low molecular weight heparines are more widely used than standard heparin because of the possibility to be administered once daily subcutaneously. They don't require a strict laboratory control and can be used in outpatients or home conditions.

[Dermoid, epidermoid and teratoma cysts of the tongue and oral cavity floor]. / Dermoidni, epidermoidni i teratomni kisti na ezika i poda na ustnata kukhina.

Most dermoid cysts in the oral cavity floor are derived from epithelial debris or rests, enclaved during midline closure of the bilateral first and second branchial arches. They may also result from ectodermal differentiation of multipotential cells, most likely pinched off at the time of anterior neuropore closure. Congenital epidermoid cysts and teratomata of the tongue may be explained in a similar manner. Only 6.9 per cent of dermoid cysts observed in humans involve the head and neck regions. Treatment consists in complete surgical removal, with excellent prognosis in cases free of complications. This is a report on a rare case of epidermoid cyst, described because of its unusual location and cell population variation of the epithelium lining the cystic cavity.

[Colorectal carcinoma and molecular genetics]. / Kolorektalen rak i molekuliarna genetika.

In the last few years, problems relating to genetic determination of colorectal carcinoma are comprehensively discussed by a number of authors. The new elaborations concerning the familial polypoid and carcinoid syndromes discovered, as well as molecular researches along this line answer a great number of questions posed in connection with substantiating the old idea about many-staged cancerigenesis. As much as 94 per cent of colorectal carcinoma cases are assigned to the sporadic cancer diagnosis category. Familial polyposis accounts for 1 per cent of all neoplasms of the colon, while the remainder 5 per cent make part of diverse familial carcinoid syndromes. Most of the data on genetic etiology of colorectal carcinoma so far elucidated are presented in a summed up fashion.