ABSTRACT
Hypopigmentation most commonly affecting the face and mouth of the Belgian Tervuren dog was characterized by an absence of melanocytes in the epidermis. Pigment loss usually occurred during young adulthood, and although there was partial repigmentation in some dogs, complete repigmentation did not occur. Treatment with vitamin and mineral supplements was unrewarding. The condition appeared to have some degree of heritability and to be similar to vitiligo in man.
Subject(s)
Dog Diseases , Pigmentation Disorders/veterinary , Adrenocorticotropic Hormone/therapeutic use , Animals , Dog Diseases/drug therapy , Dog Diseases/pathology , Dogs , Female , Gingiva/pathology , Lip/pathology , Male , Pigmentation Disorders/drug therapy , Pigmentation Disorders/pathology , Skin/pathology , Vitamins/therapeutic use , Zinc/therapeutic useABSTRACT
A profoundly retarded, 12-year-old female is described. Her phenotype is compatible with the clinical features of the trisomy 9p syndrome. Cytogenetic analyses showed her to be trisomic for 9pter leads to 9q22 and monosomic for 13pter leads to 13q12, as the result of adjacent-2 segregation during meiosis in her mother. The family pedigree shows this (9;13) translocation to be present in at least three generations.
Subject(s)
Chromosome Aberrations , Chromosomes, Human, 13-15 , Chromosomes, Human, 21-22 and Y , Chromosomes, Human, 6-12 and X , Translocation, Genetic , Trisomy , Abnormalities, Multiple/genetics , Aneuploidy , Child , Dermatoglyphics , Female , Humans , Intellectual Disability/genetics , PedigreeABSTRACT
A seven-generation pedigree of apparent X-linked, nonspecific mental retardation is reported. There are 19 known affected males who appear to have received the gene through normal mothers. Retardation, lack of fine motor coordination, hyperactivity and a speech defect are the characteristics of affected individuals studied.
