1.
J Pharm Sci
; 81(4): 365-6, 1992 Apr.
Article
in English
| MEDLINE
| ID: mdl-1501075
ABSTRACT
Ten new substituted 2-mercapto-3-(N-aryl)pyrimido[5,4-c]cinnolin-4- (3H)-ones (4) were prepared by refluxing substituted 4-aminocinnolin-3-carboxylic acid (3) with substituted arylisothiocyanate in anhydrous pyridine. These derivatives were evaluated for their antimicrobial and anti-inflammatory activities. Some of the title compounds possess potent antimicrobial activity.
Subject(s)
Anti-Bacterial Agents/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Pyridazines/chemical synthesis , Pyrimidines/chemical synthesis , Animals , Anti-Bacterial Agents/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Carrageenan , Edema/chemically induced , Edema/drug therapy , Escherichia coli/drug effects , Female , Male , Microbial Sensitivity Tests , Pseudomonas aeruginosa/drug effects , Pyridazines/pharmacology , Pyrimidines/pharmacology , Rats
2.
Arch Pharm Ber Dtsch Pharm Ges
; 303(7): 560-2, 1970 Jul.
Article
in German
| MEDLINE
| ID: mdl-5273082
3.
J Med Chem
; 11(6): 1270, 1968 Nov.
Article
in English
| MEDLINE
| ID: mdl-5680070