ABSTRACT
Beta-tricalcium phosphate (ß-TCP), one of the most widely used bioresorbable materials for bone therapy, can be doped with magnesium ions, generating ß-TCMP. The objectives of this work were to evaluate, on a murine dental alveolus grafting model, the biocompatibility of ß-TCP and ß-TMCP granules by histomorphometric analysis, as well as the impact on plasmatic levels of receptor activator of nuclear factor κB ligand (RANK-L), osteoprotegerin (OPG), osteocalcin, osteopontin, and parathormone (PTH) during bone repair, using Luminex multiplexing technology. After grafting for 42 days, ß-TCP grafted group presented higher bioresorption and induced more newly formed bone than ß-TCMP (p < 0.05). ß-TCP grafting also induced higher plasmatic levels of RANK-L, compared to ß-TCMP and control (blood clot) groups at 21st day (p < 0.05). PTH, which remained at low levels in control group, presented a time-dependent increase in grafted groups, attaining significantly higher levels with ß-TCP by the 42nd day (p < 0.05). RANK-L/OPG ratio increased on ß-TCP group and attained a peak on the 21st day. In conclusion, ß-TCP granules were more bioresorbable and osteogenic than ß-TCMP granules, and the resorption of both materials might have been affected by osteoclastogenesis modulated by changes in the plasmatic levels of PTH and RANK-L.