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Effects of Thermoextracts of Brucella S and L Forms on Lipid Peroxidation and Antioxidant Defense in Organs of Laboratory Animals.
Dubrovina, V I; Balakhonov, S V; Yurieva, O V; Starovoitova, T P; Barannikova, N L; Tokareva, L E; Pyatidesyatnikova, A B; Yastremskaya, K Yu; Shkaruba, T T.
Bull Exp Biol Med ; 165(2): 239-242, 2018 Jun.
Article in English | MEDLINE | ID: mdl-29923000

ABSTRACT

The dynamics of LPO marker malondialdehyde formation and peroxidase-destroying activity was studied in homogenized organs of guinea pigs, immunized with thermoextracts from S and L forms Brucella abortus I-206. The L form brucella thermoextract exhibited a lower reactogenicity and adequately activated the antioxidant system, due to which the destructive effects of ROS could be partially neutralized during the vaccinal process.


Subject(s)
Animal Structures/drug effects , Antioxidants/metabolism , Brucella Vaccine/pharmacology , Brucella abortus/chemistry , Lipid Peroxidation/drug effects , Vaccines, Attenuated/pharmacology , Animal Structures/metabolism , Animals , Animals, Laboratory , Brucella Vaccine/chemistry , Brucella abortus/immunology , Brucella abortus/pathogenicity , Female , Guinea Pigs , L Forms/physiology , Liver/drug effects , Liver/metabolism , Liver/pathology , Male , Oxidative Stress/drug effects , Spheroplasts/physiology , Temperature , Vaccines, Attenuated/chemistry
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