1.
Mech Ageing Dev
; 129(11): 671-2, 2008 Nov.
Article
in English
| MEDLINE
| ID: mdl-18952119
ABSTRACT
This commentary offers several views of frailty, and provides an excerpt of the dynamic model proposed by Varadhan et al., noting that it is of a traditional, causal feedback type. Key features of the authors' model are examined, and some limitations identified. (Other more modern approaches are suggested, but not expanded.) In spite of its simplicity, the deterministic feedback model as presented does indicate that weakened connectivity among feedback loops is a possible basis of frailty. In contrast, a nodal-network style of modeling might emphasize nodal failure as well as (or instead of) connectivity failure as the dynamic signature of frailty.
Subject(s)
Aging/physiology , Disease Susceptibility , Frail Elderly , Models, Biological , Stress, Physiological , Systems Biology , Aged , Aged, 80 and over , Biomarkers/metabolism , Feedback, Physiological , Homeostasis , Humans , Phenotype , Reproducibility of Results , Time Factors
2.
J Appl Physiol (1985)
; 104(6): 1849; author reply 1851, 2008 06.
Article
in English
| MEDLINE
| ID: mdl-18584787
3.
Am J Physiol Regul Integr Comp Physiol
; 285(5): R932, 2003 Nov.
Article
in English
| MEDLINE
| ID: mdl-14557229
4.
Neurobiol Aging
; 23(1): 17-9, 2002.
Article
in English
| MEDLINE
| ID: mdl-11755012