INTERDEPENDENCE OF THE MICROBIOCENOSE COMPOSITION OF BIOPELLICLE AND THE SEVERITY DEGREE OF CHANGES IN THE MUCOSA OF THE GUMS AFTER TEN WEEKS OF EXPERIMENTAL OPIOID EXPOSURE.

OBJECTIVE: The aim: To study the relationship between the degree severity of changes in the tunica mucosa of the rats gums and the composition of the microbiota of tooth surface in the gingival margin under the ten-week action of the opioid. PATIENTS AND METHODS: Materials and methods: The study was performed on 34 male rats, weighing 160 - 255 g, aged 4.5 - 7 months. Animals were administered nalbuphine for 10 weeks, gradually increasing the dose (0.212 - 0.283 mg/kg). The research of the bacterial from the microbiotope of tooth surface in the gingival margin of rats was performed using statistical analysis of quantitative results. RESULTS: Results: The 4 stages of development of the pathological process and changes in the qualitative and quantitative composition of the microbiocenosis in the gingival margin of the oral mucosa are determined. Depending on the severity of pathological changes in the mucous membrane of the gums of rats under the long-term action of the opioid, a significant increase in the quantitative indicators of bacterial species of pathogenic and opportunistic microbiota at degree IV of the process compared with degree I. The appearance of potential pathogens of purulent-inflammatory processes - Klebsiella and Pseudomonas aeruginosa was noted. CONCLUSION: Conclusions: The relationship between the quantitative and qualitative characteristics of the microbiocenosis of tooth surface in the gingival margin and the severity of changes in the mucous membrane of the of rats gums under the ten-week action of the opioid was determined, indicating bacterial associations of dental biopellicle as an etiological factor.

HEALTH DYNAMICS OF THE MEDICAL UNIVERSITY STUDENTS DURING SPORTS ACTIVITIES.

OBJECTIVE: The aim: Is to investigate the dynamics of the morphofunctional development and physical health of students who were engaged in strength sports while studying at university. PATIENTS AND METHODS: Materials and methods: The study involved 360 male students of different faculties between the ages of 17 and 20. Two groups of students were formed: experimental and control groups. The EG students (n=40) were engaged in strength sports (powerlifting, athletics, Crossfit); the CG students (n=320) were training according to the current program of physical education. The study of the morphofunctional development of students was carried out taking account of the indicators of body length, body weight, handgrip test, heart rate, blood pressure, and vital capacity. The level of students' health was examined according to the methodology of the assessment of the physical health level by G. L. Apanasenko. RESULTS: Results: It was established that strength sports at university affect physical development, functional abilities of the major systems of an organism, and the health state of future doctors in a more efficient way than the current program of physical education. It was found that the influence on the indicators of handgrip test, vital capacity, and heart rate of the EG students was the most prominent positive effect of sports. The evaluation of the calculated indexes (power index, life index) and the level of physical health confirmed this trend. CONCLUSION: Conclusions: The conducted research asserts the necessity of introducing the sports-oriented form of the physical training organization at the medical higher education institutions of Ukraine to strengthen the students' health and to maintain the efficiency of the future doctors' professional activity.