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Rev Mal Respir ; 37(3): 193-196, 2020 Mar.
Article in French | MEDLINE | ID: mdl-32146057

ABSTRACT

In addition to its role in erythropoiesis, erythropoietin (Epo) plays a role in tissue protection, which includes cardioprotective, nephroprotective and neuroprotective effects. The presence of Epo and its receptor (Epo-R) in pulmonary tissue also suggests a cytoprotective effect of Epo in the lung. Our project aims to document this role in a murine model under-expressing Epo. The obtained results will lead to a better understanding of the cytoprotective effects of Epo and will also give an appreciation of its beneficial effects in cases of lung injury.


Subject(s)
Acute Lung Injury/pathology , Cytoprotection , Erythropoietin/pharmacology , Erythropoietin/physiology , Kidney , Animals , Cytoprotection/drug effects , Cytoprotection/genetics , Disease Models, Animal , Erythropoietin/genetics , Hematopoiesis/drug effects , Hematopoiesis/genetics , Humans , Kidney/drug effects , Kidney/pathology , Lung/drug effects , Lung/pathology , Lung/physiology , Mice
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