ABSTRACT
Olfactory neuroblastoma is rare. We conducted a retrospective study to review our experience with minimally invasive resection of olfactory neuroblastomas via a transnasal endoscopic technique, including an analysis of surgical outcomes. Our series included 5 patients-3 men and 2 women, aged 29 to 75 years (mean: 48). Surgical outcomes were evaluated on the basis of each patient's preoperative Dulguerov classification and postoperative evaluation on computed tomography and magnetic resonance imaging. One patient was treated with surgery alone, 3 with surgery plus radiotherapy, and 1 with surgery, radiotherapy, and chemotherapy. During follow-up of 18 to 115 months, all 5 patients remained alive and disease-free. We found that endoscopic resection of olfactory neuroblastoma is a feasible and effective procedure, even in patients with more aggressive stages of disease. We also believe that the Dulguerov classification is more useful than other classifications for clinical management and surgical planning. Long-term follow-up is necessary to look for late recurrence.
Subject(s)
Endoscopy/methods , Esthesioneuroblastoma, Olfactory/surgery , Nasal Cavity/surgery , Nose Neoplasms/surgery , Adult , Aged , Esthesioneuroblastoma, Olfactory/diagnostic imaging , Esthesioneuroblastoma, Olfactory/pathology , Female , Humans , Male , Middle Aged , Nasal Cavity/diagnostic imaging , Neoplasm Grading , Neoplasm Staging , Nose Neoplasms/diagnostic imaging , Nose Neoplasms/pathologyABSTRACT
Leiomyoma usually originates from the uterus and alimentary tract, but rarely from the soft tissue of the head and neck. It is extremely rare that leiomyoma appears in the external auditory canal. A 47-year-old male with left external auditory canal leiomyoma presented with conductive hearing impairment and post-auricular swelling. Tumor excision was successful via a retroauricular approach. The pathological examination demonstrated a vascular leiomyoma without malignant change. To date, including our case, only three cases of external auditory canal leiomyoma have been reported. The tumor occurs mainly in adult males aged around 50 and should be included in the differential diagnoses for external auditory canal tumor. The proper treatment of choice is complete excision. In case of an external auditory canal tumor, even if it is believed to be benign before surgery, precise pathologic examination is required to exclude the possibility of malignancy.
Subject(s)
Ear Canal/surgery , Ear Neoplasms/diagnosis , Ear Neoplasms/surgery , Leiomyoma/diagnosis , Leiomyoma/surgery , Audiometry, Pure-Tone , Diagnosis, Differential , Ear Neoplasms/pathology , Hearing Loss, Conductive/etiology , Humans , Immunohistochemistry , Leiomyoma/pathology , Male , Middle Aged , Otologic Surgical Procedures , Otoscopy , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
Hyalinizing clear cell carcinoma (HCCC) of the salivary gland is new disease only recognized in recent years. It is rare and the standard treatment is still under investigation. This is a report of a 42-year-old female with HCCC who presented with a painless submucosal hard palatal mass of three years duration. Wide excision of the tumour and the underlying palatal and maxillary bones was performed. Pathological examination revealed typical clear cells arranged in anastomosing trabeculae, cords, nests, or solid sheets with a hyalinizing stroma. These clear cells were positive for the periodic acid-Schiff (PAS) reaction but were negative for the mucin stain. Immunohistochemically, these neoplastic cells were positive for cytokeratin, but negative for actin. No recurrence nor distant metastasis was found during the eight-month follow-up period.
